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ONTOLOGY REPORT - ANNOTATIONS


Term:EMC complex
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Accession:GO:0072546 term browser browse the term
Definition:A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
Comment:Note that this complex used to be thought to be involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane, but newer findings show that this was incorrect.
Synonyms:exact_synonym: ER membrane protein complex
 broad_synonym: endoplasmic reticulum membrane protein complex


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EMC complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Emc1 ER membrane protein complex subunit 1 part_of ISO
IBA
(PMID:22119785)
PMID:21873635
RGD PMID:22119785, PMID:21873635 RGD:13792537 NCBI chr 5:157,820,908...157,846,226
Ensembl chr 5:157,820,908...157,846,226
JBrowse link
G Emc10 ER membrane protein complex subunit 10 part_of ISS
ISO
IBA
GO_REF:0000024
(PMID:22119785)
PMID:21873635
UniProt
RGD
PMID:22119785, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:100,495,112...100,501,468
Ensembl chr 1:100,495,119...100,501,437
JBrowse link
G Emc2 ER membrane protein complex subunit 2 part_of ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:22119785)
UniProt
RGD
PMID:22119785, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 7:82,338,639...82,377,389
Ensembl chr 7:82,338,663...82,377,109
JBrowse link
G Emc3 ER membrane protein complex subunit 3 part_of ISO
IBA
ISS
(PMID:22119785)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:22119785, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:145,471,466...145,487,375
Ensembl chr 4:145,471,454...145,487,426
JBrowse link
G Emc4 ER membrane protein complex subunit 4 part_of IBA
ISO
PMID:21873635
(PMID:22119785)
RGD PMID:22119785, PMID:21873635 RGD:13792537 NCBI chr 3:103,852,139...103,857,172
Ensembl chr 3:103,852,139...103,857,158
JBrowse link
G Emc6 ER membrane protein complex subunit 6 part_of ISO
IBA
(PMID:22119785)
PMID:21873635
RGD PMID:22119785, PMID:21873635 RGD:13792537 NCBI chr10:59,741,772...59,743,338
Ensembl chr10:59,741,772...59,743,315
JBrowse link
G Emc7 ER membrane protein complex subunit 7 part_of ISO
IBA
(PMID:22119785)
PMID:21873635
RGD PMID:22119785, PMID:21873635 RGD:13792537 NCBI chr 3:103,945,276...103,955,970
Ensembl chr 3:103,945,329...103,956,007
JBrowse link
G Emc8 ER membrane protein complex subunit 8 part_of IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:22119785)
UniProt
RGD
PMID:22119785, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr19:54,235,949...54,245,810
Ensembl chr19:54,235,936...54,245,855
JBrowse link
G Emc9 ER membrane protein complex subunit 9 part_of IBA
ISO
ISS
PMID:21873635
(PMID:22119785)
GO_REF:0000024
RGD
UniProt
PMID:22119785, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr15:34,258,940...34,263,156
Ensembl chr15:34,256,374...34,263,224
JBrowse link
G Mmgt1 membrane magnesium transporter 1 part_of ISO
ISS
IBA
(PMID:22119785)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:22119785, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr  X:158,966,694...158,978,995
Ensembl chr  X:158,966,673...158,978,995
JBrowse link
G Mmgt2 membrane magnesium transporter 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:48,986,163...48,989,596 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20011
    protein-containing complex 6011
      endoplasmic reticulum protein-containing complex 139
        EMC complex 11
Path 2
Term Annotations click to browse term
  cellular_component 20011
    cellular anatomical entity 19715
      organelle 13098
        intracellular organelle 12747
          intracellular membrane-bounded organelle 11193
            endoplasmic reticulum 1757
              endoplasmic reticulum subcompartment 961
                endoplasmic reticulum membrane 951
                  intrinsic component of endoplasmic reticulum membrane 151
                    integral component of endoplasmic reticulum membrane 143
                      EMC complex 11
paths to the root