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ONTOLOGY REPORT - ANNOTATIONS


Term:pyrimidine-containing compound metabolic process
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Accession:GO:0072527 term browser browse the term
Definition:The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof.
Synonyms:exact_synonym: pyrimidine and derivative metabolic process;   pyrimidine-containing compound metabolism


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'de novo' pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase ISO (PMID:24332717) UniProtKB
RGD
PMID:1476792, PMID:24332717 RGD:5132591 NCBI chr2A:27,218,699...27,245,156
Ensembl chr2A:27,306,527...27,332,804
JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) ISO RGD PMID:1476792 RGD:5132591 NCBI chr16:52,977,879...52,994,496
Ensembl chr16:71,854,238...71,870,673
JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO (MGI:5469988|PMID:23429704) CACAO PMID:23429704 MGI:5469988 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841
JBrowse link
5-methylcytosine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TET2 tet methylcytosine dioxygenase 2 ISO (PMID:24315485) UniProtKB PMID:24315485 NCBI chr 4:97,612,439...97,745,544
Ensembl chr 4:108,269,082...108,358,400
JBrowse link
5-methylcytosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TET2 tet methylcytosine dioxygenase 2 ISO (MGI:5298314|PMID:21803851) MGI PMID:21803851 MGI:5298314 NCBI chr 4:97,612,439...97,745,544
Ensembl chr 4:108,269,082...108,358,400
JBrowse link
CDP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO RGD PMID:3010881 RGD:5133253 NCBI chr 1:46,642,602...46,673,568 JBrowse link
CTP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTPS1 CTP synthase 1 ISO (PMID:24870241)
(PMID:16179339)
UniProtKB PMID:16179339, PMID:24870241 NCBI chr 1:40,275,581...40,308,421
Ensembl chr 1:41,592,509...41,624,455
JBrowse link
cytidine deamination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase ISO (MGI:2656023|PMID:12692563) UniProt PMID:12692563 MGI:2656023 NCBI chr12:8,688,392...8,699,008
Ensembl chr12:8,904,273...8,913,917
JBrowse link
G APOBEC3C apolipoprotein B mRNA editing enzyme catalytic subunit 3C ISO (PMID:21632763) UniProtKB PMID:21632763 NCBI chr22:19,924,116...19,930,771
Ensembl chr22:37,743,388...37,749,725
JBrowse link
G APOBEC3G apolipoprotein B mRNA editing enzyme catalytic subunit 3G ISO (PMID:16378963) UniProtKB PMID:16378963 NCBI chr22:19,977,184...19,994,769 JBrowse link
G CDA cytidine deaminase ISO (PMID:9596658) RGD
UniProtKB
PMID:675715, PMID:9596658 RGD:2316616 NCBI chr 1:19,538,696...19,568,008
Ensembl chr 1:20,583,441...20,612,711
JBrowse link
G CDADC1 cytidine and dCMP deaminase domain containing 1 ISO (PMID:26945630) UniProtKB PMID:26945630 NCBI chr13:30,386,671...30,432,112
Ensembl chr13:49,138,498...49,186,541
JBrowse link
cytosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 ISO (MGI:3510481|PMID:15284227) MGI PMID:15284227 MGI:3510481 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335
JBrowse link
G TET2 tet methylcytosine dioxygenase 2 ISO (MGI:5298314|PMID:21803851) MGI PMID:21803851 MGI:5298314 NCBI chr 4:97,612,439...97,745,544
Ensembl chr 4:108,269,082...108,358,400
JBrowse link
dCDP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO RGD PMID:192455 RGD:5133256 NCBI chr 1:46,642,602...46,673,568 JBrowse link
dCTP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCTPP1 dCTP pyrophosphatase 1 ISO (PMID:24467396) UniProtKB PMID:24467396 NCBI chr16:24,538,023...24,545,426
Ensembl chr16:30,794,268...30,802,179
JBrowse link
deoxycytidine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCK deoxycytidine kinase ISO RGD PMID:7686601, PMID:8305745 RGD:2300395, RGD:2300398 NCBI chr 4:53,193,475...53,230,708 JBrowse link
G TK2 thymidine kinase 2 ISO RGD PMID:21444706 RGD:5134349 NCBI chr16:46,793,679...46,868,508
Ensembl chr16:65,928,102...65,970,315
JBrowse link
dTDP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMPK2 cytidine/uridine monophosphate kinase 2 ISO RGD PMID:192455 RGD:5133256 NCBI chr2A:6,856,242...6,874,567 JBrowse link
G DTYMK deoxythymidylate kinase ISO (MGI:77260|PMID:8845311) RGD
MGI
PMID:220041, PMID:8845311 MGI:77260, RGD:5133687 NCBI chr2B:128,952,009...128,963,640
Ensembl chr2B:247,740,881...247,752,504
JBrowse link
dTMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SHMT1 serine hydroxymethyltransferase 1 ISO (MGI:3849912|PMID:19513116) BHF-UCL PMID:19513116 MGI:3849912 NCBI chr17:32,870,949...32,905,690
Ensembl chr17:37,849,206...37,884,220
JBrowse link
G TYMS thymidylate synthetase ISO (PMID:11278511), (PMID:15093541), (PMID:8845352) CAFA
RGD
PMID:8845352, PMID:9894005, PMID:11278511, PMID:15093541 RGD:1545055 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320
JBrowse link
dTTP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DTYMK deoxythymidylate kinase ISO RGD PMID:220041 RGD:5133687 NCBI chr2B:128,952,009...128,963,640
Ensembl chr2B:247,740,881...247,752,504
JBrowse link
G TBPL1 TATA-box binding protein like 1 ISO (MGI:2159505|PMID:11861477) MGI PMID:11861477 MGI:2159505 NCBI chr 6:131,719,606...131,754,960
Ensembl chr 6:135,817,613...135,852,876
JBrowse link
dTTP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCTPP1 dCTP pyrophosphatase 1 NOT ISO (PMID:24467396) UniProtKB PMID:24467396 NCBI chr16:24,538,023...24,545,426
Ensembl chr16:30,794,268...30,802,179
JBrowse link
dUDP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO RGD PMID:3010881 RGD:5133253 NCBI chr 1:46,642,602...46,673,568 JBrowse link
G CMPK2 cytidine/uridine monophosphate kinase 2 ISO RGD PMID:192455 RGD:5133256 NCBI chr2A:6,856,242...6,874,567 JBrowse link
dUMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUT deoxyuridine triphosphatase ISO RGD PMID:1315924, PMID:3032103 RGD:2300191, RGD:2301218 NCBI chr15:27,280,025...27,292,003
Ensembl chr15:45,603,807...45,616,022
JBrowse link
dUMP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NT5M 5',3'-nucleotidase, mitochondrial ISO (MGI:2388903|PMID:12234672) MGI PMID:12234672 MGI:2388903 NCBI chr17:33,948,270...33,991,485 JBrowse link
dUTP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUT deoxyuridine triphosphatase ISO RGD PMID:1315924, PMID:3032103 RGD:2300191, RGD:2301218 NCBI chr15:27,280,025...27,292,003
Ensembl chr15:45,603,807...45,616,022
JBrowse link
pyrimidine deoxyribonucleotide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NT5C 5', 3'-nucleotidase, cytosolic ISO (PMID:10681516) UniProtKB PMID:10681516 NCBI chr17:69,077,021...69,078,998 JBrowse link
pyrimidine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase ISO (PMID:11988088)
(MGI:2657070|PMID:12651209)
UniProtKB
MGI
RGD
PMID:1629785, PMID:11988088, PMID:12651209 MGI:2657070, RGD:1599794 NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100
JBrowse link
G DPYS dihydropyrimidinase ISO (PMID:9718352) UniProtKB PMID:9718352 NCBI chr 8:101,008,090...101,096,234
Ensembl chr 8:103,160,922...103,248,303
JBrowse link
pyrimidine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr11:3,956,528...3,999,205
Ensembl chr11:4,068,119...4,110,474
JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr2A:10,119,508...10,128,318
Ensembl chr2A:10,275,598...10,284,640
JBrowse link
G TYMS thymidylate synthetase ISO 5-fluorocytosine RGD PMID:9524100 RGD:5133447 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320
JBrowse link
pyrimidine nucleoside catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UPB1 beta-ureidopropionase 1 ISO (PMID:22525402) UniProt PMID:22525402 NCBI chr22:5,300,686...5,332,735
Ensembl chr22:22,166,370...22,197,360
JBrowse link
pyrimidine nucleoside metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TYMP thymidine phosphorylase ISO (PMID:9924029)
(PMID:1590793)
CAFA PMID:1590793, PMID:9924029 NCBI chr22:30,772,088...30,776,618 JBrowse link
pyrimidine nucleotide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCK deoxycytidine kinase ISO (PMID:12808445) UniProtKB PMID:12808445 NCBI chr 4:53,193,475...53,230,708 JBrowse link
G ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 ISO (PMID:11342463) UniProtKB PMID:11342463 NCBI chr 6:129,428,107...129,530,898
Ensembl chr 6:133,544,644...133,641,043
JBrowse link
G UPP1 uridine phosphorylase 1 ISO (MGI:3584214|PMID:15772079) MGI PMID:15772079 MGI:3584214 NCBI chr 7:48,729,975...48,749,598
Ensembl chr 7:48,838,893...48,858,185
JBrowse link
thiamine diphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THTPA thiamine triphosphatase ISO (MGI:3796446|PMID:18276586) UniProt PMID:18276586 MGI:3796446 NCBI chr14:4,374,439...4,378,028
Ensembl chr14:22,467,506...22,471,356
JBrowse link
thiamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP3 acid phosphatase 3 ISO (MGI:3849266|PMID:18940592) UniProt PMID:18940592 MGI:3849266 NCBI chr 3:129,392,396...129,465,962
Ensembl chr 3:136,713,816...136,764,655
JBrowse link
G TPK1 thiamin pyrophosphokinase 1 ISO (MGI:1350425|PMID:10567383) MGI PMID:10567383 MGI:1350425 NCBI chr 7:136,165,941...136,549,606
Ensembl chr 7:148,654,445...149,036,342
JBrowse link
thymidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHFR2 dihydrofolate reductase 2 ISO (PMID:21876188) UniProtKB PMID:21876188 NCBI chr 3:91,125,295...91,128,378 JBrowse link
thymidine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase ISO (PMID:1512248) UniProtKB PMID:1512248 NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100
JBrowse link
thymidine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TK1 thymidine kinase 1 ISO phosphorylation RGD PMID:6642140 RGD:2317232 NCBI chr17:72,251,416...72,265,308
Ensembl chr17:77,803,749...77,816,747
JBrowse link
G TK2 thymidine kinase 2 ISO RGD PMID:21444706 RGD:5134349 NCBI chr16:46,793,679...46,868,508
Ensembl chr16:65,928,102...65,970,315
JBrowse link
thymine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 ISO (PMID:23835272) BHF-UCL
RGD
PMID:2768248, PMID:23835272 RGD:1599052 NCBI chr14:54,616,531...54,643,346
Ensembl chr14:73,472,255...73,495,734
JBrowse link
G DPYD dihydropyrimidine dehydrogenase ISO (PMID:10410956) UniProtKB PMID:10410956 NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100
JBrowse link
G DPYS dihydropyrimidinase ISO PMID:8307005 UniProt PMID:8307005 RGD:1624990 NCBI chr 8:101,008,090...101,096,234
Ensembl chr 8:103,160,922...103,248,303
JBrowse link
thymine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 ISO PMID:2768248 UniProt PMID:2768248 RGD:1599052 NCBI chr14:54,616,531...54,643,346
Ensembl chr14:73,472,255...73,495,734
JBrowse link
UDP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMPK1 cytidine/uridine monophosphate kinase 1 ISO RGD PMID:3010881 RGD:5133253 NCBI chr 1:46,642,602...46,673,568 JBrowse link
UDP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 ISO (PMID:9556635) UniProtKB PMID:9556635 NCBI chr 8:22,678,746...22,707,408
Ensembl chr 8:19,571,337...19,635,150
JBrowse link
UMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UMPS uridine monophosphate synthetase ISO (PMID:11730338), (PMID:6893554) UniProtKB
RGD
PMID:6134725, PMID:6893554, PMID:11730338 RGD:5132277 NCBI chr 3:121,832,758...121,851,707
Ensembl chr 3:128,731,355...128,745,029
JBrowse link
G UPRT uracil phosphoribosyltransferase homolog ISO RGD PMID:1476792 RGD:5132591 NCBI chr  X:64,524,889...64,561,439
Ensembl chr  X:74,639,179...74,675,221
JBrowse link
uracil catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase ISO (PMID:1512248), (PMID:18075467) UniProtKB PMID:1512248, PMID:18075467 NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100
JBrowse link
G DPYS dihydropyrimidinase ISO (PMID:18075467)
(PMID:10410956)
PMID:8307005
UniProtKB
UniProt
PMID:8307005, PMID:10410956, PMID:18075467 RGD:1624990 NCBI chr 8:101,008,090...101,096,234
Ensembl chr 8:103,160,922...103,248,303
JBrowse link
uracil metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase ISO RGD PMID:7626590 RGD:1624989 NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100
JBrowse link
G DPYS dihydropyrimidinase ISO RGD PMID:7626590, PMID:8307005 RGD:1624989, RGD:1624990 NCBI chr 8:101,008,090...101,096,234
Ensembl chr 8:103,160,922...103,248,303
JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:2043679 RGD:5133426 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320
JBrowse link
uridine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UPP1 uridine phosphorylase 1 ISO (PMID:7488099)
(MGI:5476603|PMID:23355744), (MGI:73237|PMID:7744869)
UniProt
CACAO
PMID:7488099, PMID:7744869, PMID:23355744 MGI:5476603, MGI:73237 NCBI chr 7:48,729,975...48,749,598
Ensembl chr 7:48,838,893...48,858,185
JBrowse link
G UPP2 uridine phosphorylase 2 ISO (PMID:12849978), (PMID:21855639)
(MGI:2683856|PMID:14715930)
UniProt PMID:12849978, PMID:14715930, PMID:21855639 MGI:2683856 NCBI chr2B:45,363,103...45,400,281
Ensembl chr2B:162,496,507...162,636,231
JBrowse link
uridine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UPP1 uridine phosphorylase 1 ISO (MGI:3584214|PMID:15772079) MGI PMID:15772079 MGI:3584214 NCBI chr 7:48,729,975...48,749,598
Ensembl chr 7:48,838,893...48,858,185
JBrowse link
UTP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase ISO RGD PMID:10659854 RGD:2303528 NCBI chr2A:27,218,699...27,245,156
Ensembl chr2A:27,306,527...27,332,804
JBrowse link
UTP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AK3 adenylate kinase 3 ISO (PMID:11485571) BHF-UCL PMID:11485571 NCBI chr 9:4,541,984...4,576,341
Ensembl chr 9:4,732,847...4,762,900
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12566
    metabolic process 7977
      nitrogen compound metabolic process 6686
        cellular nitrogen compound metabolic process 4224
          pyrimidine-containing compound metabolic process 42
            5-methylcytosine metabolic process + 1
            orotic acid metabolic process 0
            pyrimidine nucleobase metabolic process + 11
            pyrimidine nucleoside metabolic process + 14
            pyrimidine nucleotide metabolic process + 19
            pyrimidine-containing compound biosynthetic process + 14
            pyrimidine-containing compound catabolic process + 17
            thiamine diphosphate metabolic process + 1
            thiamine-containing compound metabolic process + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.