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ONTOLOGY REPORT - ANNOTATIONS


Term:blood coagulation, fibrin clot formation
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Accession:GO:0072378 term browser browse the term
Definition:A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.
Comment:See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'.


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blood coagulation, fibrin clot formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F13a1 coagulation factor XIII A1 chain IEA
ISO
IBA
ISS
GO_REF:0000107
MGI:5645817 (MGI:5645809|PMID:18224415)
PMID:21873635
GO_REF:0000024
(PMID:27363989)
Ensembl
RGD
UniProt
PMID:18224415, PMID:27363989, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:5645809, RGD:13792537 NCBI chr17:28,504,650...28,680,015
Ensembl chr17:28,504,623...28,680,362
JBrowse link
G Fbln1 fibulin 1 ISO (PMID:7642629) RGD PMID:7642629 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fga fibrinogen alpha chain ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgb fibrinogen beta chain ISO
IBA
(PMID:16846481)
PMID:21873635
RGD PMID:16846481, PMID:21873635 RGD:13792537 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fgg fibrinogen gamma chain ISO
IBA
(PMID:11001902), (PMID:16846481)
PMID:21873635
RGD PMID:11001902, PMID:16846481, PMID:21873635 RGD:13792537 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fn1 fibronectin 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
blood coagulation, common pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fga fibrinogen alpha chain ISO
IBA
IEA
(PMID:10891444), (PMID:12706644)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:10891444, PMID:12706644, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
blood coagulation, extrinsic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F5 coagulation factor V TAS RGD PMID:15172885 RGD:1601118 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
blood coagulation, intrinsic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoh apolipoprotein H ISO
IEA
(PMID:4052628)
GO_REF:0000107
RGD
Ensembl
PMID:4052628 GO_REF:0000107 NCBI chr10:96,640,013...96,653,939
Ensembl chr10:96,639,924...96,653,938
JBrowse link
G F8 coagulation factor VIII IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:2513867, PMID:21873635 RGD:1582368, RGD:13792537 NCBI chr18:367,862...399,242
Ensembl chr18:367,862...399,242
JBrowse link
regulation of blood coagulation, intrinsic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serpinc1 serpin family C member 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    response to stimulus 10580
      protein activation cascade 14
        blood coagulation, fibrin clot formation 10
          blood coagulation, common pathway + 1
          blood coagulation, extrinsic pathway + 1
          blood coagulation, intrinsic pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological quality 4280
        regulation of body fluid levels 418
          hemostasis 189
            blood coagulation 187
              blood coagulation, fibrin clot formation 10
                blood coagulation, common pathway + 1
                blood coagulation, extrinsic pathway + 1
                blood coagulation, intrinsic pathway + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.