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ONTOLOGY REPORT - ANNOTATIONS


Term:protein activation cascade
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Accession:GO:0072376 term browser browse the term
Definition:A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events.
Synonyms:exact_synonym: protein activation pathway;   protein activitory cascade


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protein activation cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvp major vault protein ISO (MGI:5486560|PMID:15133037) RGD PMID:15133037 MGI:5486560 NCBI chr 1:198,420,813...198,448,612
Ensembl chr 1:198,420,806...198,450,047
JBrowse link
blood coagulation, common pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fga fibrinogen alpha chain ISO
IBA
IEA
(PMID:10891444), (PMID:12706644)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:10891444 PMID:12706644, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
blood coagulation, extrinsic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F5 coagulation factor V TAS RGD PMID:15172885 RGD:1601118 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
blood coagulation, fibrin clot formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F13a1 coagulation factor XIII A1 chain IEA
ISO
IBA
ISS
GO_REF:0000107
MGI:5645817 (MGI:5645809|PMID:18224415)
PMID:21873635
GO_REF:0000024
(PMID:27363989)
Ensembl
RGD
UniProt
PMID:18224415 PMID:27363989, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5645809, RGD:13792537 NCBI chr17:28,504,650...28,680,015
Ensembl chr17:28,504,623...28,680,362
JBrowse link
G Fbln1 fibulin 1 ISO (PMID:7642629) RGD PMID:7642629 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fga fibrinogen alpha chain ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgb fibrinogen beta chain ISO
IBA
(PMID:16846481)
PMID:21873635
RGD PMID:16846481, PMID:21873635 RGD:13792537 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fgg fibrinogen gamma chain ISO
IBA
(PMID:11001902), (PMID:16846481)
PMID:21873635
RGD PMID:11001902 PMID:16846481, PMID:21873635 RGD:13792537 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fn1 fibronectin 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
blood coagulation, intrinsic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoh apolipoprotein H ISO
IEA
(PMID:4052628)
GO_REF:0000107
RGD
Ensembl
PMID:4052628 GO_REF:0000107 NCBI chr10:96,640,013...96,653,939
Ensembl chr10:96,639,924...96,653,938
JBrowse link
G F8 coagulation factor VIII IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:2513867, PMID:21873635 RGD:1582368, RGD:13792537 NCBI chr18:367,862...399,242
Ensembl chr18:367,862...399,242
JBrowse link
Factor XII activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII ISO
IEA
(PMID:18725990)
GO_REF:0000107
RGD
Ensembl
PMID:18725990 GO_REF:0000107 NCBI chr17:9,736,577...9,744,420
Ensembl chr17:9,736,577...9,744,420
JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:6685967 RGD:11062094 NCBI chr11:81,509,185...81,516,759 JBrowse link
plasma kallikrein-kinin cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII ISO (PMID:18725990), (PMID:6793628) RGD PMID:6793628 PMID:18725990 NCBI chr17:9,736,577...9,744,420
Ensembl chr17:9,736,577...9,744,420
JBrowse link
G Prcp prolylcarboxypeptidase ISO MGI:4123993 (MGI:5009114|PMID:21297000) RGD PMID:21297000 MGI:5009114 NCBI chr 1:157,701,089...157,750,177
Ensembl chr 1:157,701,089...157,750,169
JBrowse link
regulation of blood coagulation, intrinsic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serpinc1 serpin family C member 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20030
    response to stimulus 10583
      protein activation cascade 14
        blood coagulation, common pathway + 1
        blood coagulation, extrinsic pathway + 1
        blood coagulation, fibrin clot formation + 10
        blood coagulation, intrinsic pathway + 3
        kinin cascade + 3
        negative regulation of protein activation cascade + 0
        positive regulation of protein activation cascade + 0
        regulation of protein activation cascade + 1
Path 2
Term Annotations click to browse term
  biological_process 20030
    metabolic process 12185
      organic substance metabolic process 11552
        macromolecule metabolic process 9966
          protein metabolic process 6023
            protein activation cascade 14
              blood coagulation, common pathway + 1
              blood coagulation, extrinsic pathway + 1
              blood coagulation, fibrin clot formation + 10
              blood coagulation, intrinsic pathway + 3
              kinin cascade + 3
              negative regulation of protein activation cascade + 0
              positive regulation of protein activation cascade + 0
              regulation of protein activation cascade + 1
paths to the root