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ONTOLOGY REPORT - ANNOTATIONS


Term:protein activation cascade
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Accession:GO:0072376 term browser browse the term
Definition:A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events.
Synonyms:exact_synonym: protein activation pathway;   protein activitory cascade



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protein activation cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvp major vault protein involved_in ISO (MGI:5486560|PMID:15133037) RGD PMID:15133037 MGI:5486560 NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380
JBrowse link
blood coagulation, common pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II involved_in ISO (PMID:22457833) RGD PMID:22457833 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fga fibrinogen alpha chain involved_in ISO
IBA
(PMID:12706644)
PMID:21873635
(PMID:10891444)
RGD PMID:10891444 PMID:12706644 PMID:21873635 RGD:13792537 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
blood coagulation, extrinsic pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F5 coagulation factor V TAS RGD PMID:15172885 RGD:1601118 NCBI chr13:76,513,463...76,583,106
Ensembl chr13:76,513,255...76,582,317
JBrowse link
blood coagulation, fibrin clot formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F13a1 coagulation factor XIII A1 chain involved_in ISS
ISO
IEA
IBA
GO_REF:0000024
MGI:5645817 (MGI:5645809|PMID:18224415)
GO_REF:0000107
(PMID:27363989)
PMID:21873635
UniProt
RGD
Ensembl
PMID:18224415 PMID:27363989 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5645809, RGD:13792537 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
JBrowse link
G F13b coagulation factor XIII B chain involved_in ISO
IEA
(PMID:27363989)
GO_REF:0000107
RGD
Ensembl
PMID:27363989 GO_REF:0000107 NCBI chr13:51,130,851...51,156,383
Ensembl chr13:51,130,920...51,156,381
JBrowse link
G Fbln1 fibulin 1 involved_in ISO (PMID:7642629) RGD PMID:7642629 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075
JBrowse link
G Fga fibrinogen alpha chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain involved_in ISO
IBA
(PMID:16846481)
PMID:21873635
RGD PMID:16846481 PMID:21873635 RGD:13792537 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgg fibrinogen gamma chain involved_in IBA
ISO
PMID:21873635
(PMID:16846481)
(PMID:11001902), (PMID:16846481)
RGD PMID:11001902 PMID:16846481 PMID:21873635 RGD:13792537 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Fn1 fibronectin 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
blood coagulation, intrinsic pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoh apolipoprotein H involved_in ISO
IEA
(PMID:4052628)
GO_REF:0000107
RGD
Ensembl
PMID:4052628 GO_REF:0000107 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
JBrowse link
G F11 coagulation factor XI involved_in ISO (PMID:10823824) RGD PMID:10823824 NCBI chr16:46,986,107...47,009,015
Ensembl chr16:46,986,107...47,008,437
JBrowse link
G F8 coagulation factor VIII involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:2513867 PMID:21873635 RGD:1582368, RGD:13792537 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
JBrowse link
G F9 coagulation factor IX involved_in ISO (PMID:8632006) RGD PMID:8632006 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835
JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha involved_in ISO
IEA
(PMID:10501658)
GO_REF:0000107
RGD
Ensembl
PMID:10501658 GO_REF:0000107 NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774
JBrowse link
G Gp1bb glycoprotein Ib platelet subunit beta involved_in ISO
IEA
(PMID:10501658)
GO_REF:0000107
RGD
Ensembl
PMID:10501658 GO_REF:0000107 NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392
JBrowse link
G Gp5 glycoprotein V (platelet) involved_in ISO (PMID:10501658) RGD PMID:10501658 NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705
JBrowse link
G Gp9 glycoprotein IX (platelet) involved_in ISO
IEA
(PMID:10501658)
GO_REF:0000107
RGD
Ensembl
PMID:10501658 GO_REF:0000107 NCBI chr 4:120,235,539...120,236,874
Ensembl chr 4:120,235,421...120,237,110
JBrowse link
G Klkb1 kallikrein B1 involved_in ISO (PMID:874082) RGD PMID:874082 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
JBrowse link
Factor XII activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII involved_in ISO
IEA
(PMID:18725990)
GO_REF:0000107
RGD
Ensembl
PMID:18725990 GO_REF:0000107 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G Hpse heparanase involved_in ISO (PMID:20634491) RGD PMID:20634491 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:6685967 RGD:11062094 NCBI chr11:77,913,876...77,936,247 JBrowse link
plasma kallikrein-kinin cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F12 coagulation factor XII involved_in ISO (PMID:18725990), (PMID:6793628) RGD PMID:6793628 PMID:18725990 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G Prcp prolylcarboxypeptidase acts_upstream_of_or_within ISO MGI:4123993 (MGI:5009114|PMID:21297000) RGD PMID:21297000 MGI:5009114 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530
JBrowse link
regulation of blood coagulation, intrinsic pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serpinc1 serpin family C member 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
regulation of protein activation cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rasal2 RAS protein activator like 2 involved_in ISO (MGI:6480073|PMID:31408278) RGD PMID:31408278 MGI:6480073 NCBI chr13:69,279,882...69,568,647
Ensembl chr13:69,258,622...69,569,940
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19541
    response to stimulus 10453
      protein activation cascade 25
        blood coagulation, common pathway + 2
        blood coagulation, extrinsic pathway + 1
        blood coagulation, fibrin clot formation + 19
        blood coagulation, intrinsic pathway + 10
        kinin cascade + 4
        negative regulation of protein activation cascade + 0
        positive regulation of protein activation cascade + 0
        regulation of protein activation cascade + 2
Path 2
Term Annotations click to browse term
  biological_process 19541
    metabolic process 11844
      organic substance metabolic process 11378
        macromolecule metabolic process 9829
          protein metabolic process 5945
            protein activation cascade 25
              blood coagulation, common pathway + 2
              blood coagulation, extrinsic pathway + 1
              blood coagulation, fibrin clot formation + 19
              blood coagulation, intrinsic pathway + 10
              kinin cascade + 4
              negative regulation of protein activation cascade + 0
              positive regulation of protein activation cascade + 0
              regulation of protein activation cascade + 2
paths to the root