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ONTOLOGY REPORT - ANNOTATIONS

Term:Ragulator complex
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Accession:GO:0071986 term browser browse the term
Definition:A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified).
Synonyms:exact_synonym: MAPKSP1/ROBLD3/C11orf59 complex;   Rag GEF
 related_synonym: EGO complex;   EGO-GSE complex;   GSE complex;   GTPase-containing complex for Gap1p sorting in the endosome
 alt_id: GO:0034448;   GO:0034449


show annotations for term's descendants           Sort by:
Ragulator complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 part_of
is_active_in
located_in		 IEA
IBA
IDA
IPI		 (PMID:28935770), (PMID:29123114)
(PMID:20381137), (PMID:29158492), (PMID:31601708)		 InterPro
GO_Central
UniProt
ComplexPortal		 PMID:20381137 PMID:28935770 PMID:29123114 PMID:29158492 PMID:31601708 GO_REF:0000002 GO_REF:0000033 NCBI chr11:72,097,292...72,103,297
Ensembl chr11:72,085,895...72,103,297 		JBrowse link
G LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 located_in
part_of		 IPI
IDA
IBA		 (PMID:28935770)
(PMID:20381137), (PMID:28935770), (PMID:29123114), (PMID:29158492), (PMID:31601708)		 ComplexPortal
UniProt
GO_Central		 PMID:20381137 PMID:28935770 PMID:29123114 PMID:29158492 PMID:31601708 GO_REF:0000033 NCBI chr 1:156,054,782...156,058,506
Ensembl chr 1:156,054,782...156,058,506 		JBrowse link
G LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 located_in
part_of		 IPI
IEA
IBA
IDA		 (PMID:28935770)
(PMID:20381137), (PMID:28935770), (PMID:29123114), (PMID:29158492), (PMID:31601708)		 ComplexPortal
TreeGrafter
GO_Central
UniProt		 PMID:20381137 PMID:28935770 PMID:29123114 PMID:29158492 PMID:31601708 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:99,878,336...99,894,546
Ensembl chr 4:99,878,336...99,894,428 		JBrowse link
G LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 located_in
part_of		 IPI
IBA
IDA
IEA		 (PMID:28935770)
(PMID:22980980), (PMID:28935770), (PMID:29123114), (PMID:29158492), (PMID:31601708)		 ComplexPortal
GO_Central
UniProt
InterPro		 PMID:22980980 PMID:28935770 PMID:29123114 PMID:29158492 PMID:31601708 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:100,148,918...100,154,203
Ensembl chr 7:100,148,912...100,155,944 		JBrowse link
G LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 part_of
located_in		 IEA
IBA
IDA
IPI		 (PMID:22980980), (PMID:28935770), (PMID:29123114), (PMID:29158492), (PMID:31601708)
(PMID:28935770)		 InterPro
GO_Central
UniProt
ComplexPortal		 PMID:22980980 PMID:28935770 PMID:29123114 PMID:29158492 PMID:31601708 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:110,401,253...110,407,924
Ensembl chr 1:110,401,249...110,407,942 		JBrowse link
G SLC38A9 solute carrier family 38 member 9 located_in IDA (PMID:25561175), (PMID:25567906) UniProt PMID:25561175 PMID:25567906 NCBI chr 5:55,625,845...55,712,335
Ensembl chr 5:55,625,845...55,773,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20810
    protein-containing complex 7481
      membrane protein complex 1483
        Ragulator complex 6
Path 2
Term Annotations click to browse term
  cellular_component 20810
    cellular anatomical entity 20423
      organelle 15584
        intracellular organelle 14622
          intracellular membrane-bounded organelle 13434
            vacuole 917
              vacuolar membrane 517
                Ragulator complex 6
paths to the root