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ONTOLOGY REPORT - ANNOTATIONS


Term:14-3-3 protein binding
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Accession:GO:0071889 term browser browse the term
Definition:Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.



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14-3-3 protein binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aanat aralkylamine N-acetyltransferase enables IDA PMID:11427721 UniProt PMID:11427721 RGD:8553854 NCBI chr10:101,827,072...101,831,805
Ensembl chr10:101,827,301...101,831,801
JBrowse link
G Akt1 AKT serine/threonine kinase 1 enables ISO UniProtKB:P63104 (PMID:10102273) RGD PMID:10102273 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Arrb2 arrestin, beta 2 IDA RGD PMID:19008961 RGD:5510009 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Bad BCL2-associated agonist of cell death IDA RGD PMID:22757651 RGD:10053724 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Dab2ip DAB2 interacting protein enables ISO
IEA
(PMID:17389591)
GO_REF:0000107
RGD
Ensembl
PMID:17389591 GO_REF:0000107 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 enables IBA
ISO
IEA
PMID:21873635
(MGI:3773582|PMID:18198340)
GO_REF:0000107
RGD
Ensembl
PMID:18198340 PMID:21873635 GO_REF:0000107 MGI:3773582, RGD:13792537 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Foxk1 forkhead box K1 enables ISO UniProtKB:P62259 (PMID:29861159) RGD PMID:29861159 NCBI chr12:12,110,119...12,175,089
Ensembl chr12:12,115,950...12,175,089
JBrowse link
G Hdac7 histone deacetylase 7 enables ISO
IEA
ISS
(PMID:16980613)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:16980613 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:128,923,918...128,962,025
Ensembl chr 7:128,923,920...128,962,072
JBrowse link
G Irs2 insulin receptor substrate 2 IDA RGD PMID:22912850 RGD:7257698 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 IPI RGD PMID:22911758 RGD:9693692 NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740
JBrowse link
G Kif13b kinesin family member 13B enables ISO (PMID:20194617) RGD PMID:20194617 NCBI chr15:38,908,318...39,062,849
Ensembl chr15:38,924,624...39,084,879
JBrowse link
G Klhl22 kelch-like family member 22 enables ISO
IEA
UniProtKB:P62258 (PMID:29769719)
GO_REF:0000107
RGD
Ensembl
PMID:29769719 GO_REF:0000107 NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770
JBrowse link
G Ksr1 kinase suppressor of ras 1 enables ISO (PMID:29433126)
UniProtKB:P62258 (MGI:5758853|PMID:10409742)
RGD PMID:10409742 PMID:29433126 MGI:5758853 NCBI chr10:63,961,771...64,098,076
Ensembl chr10:63,961,759...64,098,076
JBrowse link
G Nek1 NIMA-related kinase 1 enables ISO (MGI:5902880|PMID:28235073) RGD PMID:28235073 MGI:5902880 NCBI chr16:28,998,229...29,125,426
Ensembl chr16:28,998,231...29,117,723
JBrowse link
G Pi4kb phosphatidylinositol 4-kinase beta enables ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:23572552)
UniProt
Ensembl
RGD
PMID:23572552 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:182,540,377...182,572,684
Ensembl chr 2:182,540,567...182,588,488
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A enables ISO
IEA
ISS
(PMID:20354225)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20354225 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Prkce protein kinase C, epsilon enables ISO UniProtKB:Q9CQV8 (MGI:5306290|PMID:18604201) RGD PMID:18604201 MGI:5306290 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkcz protein kinase C, zeta IPI RGD PMID:17308302 RGD:1642660 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Rbm7 RNA binding motif protein 7 enables ISO UniProtKB:P62258|UniProtKB:P63104 (PMID:25189701) RGD PMID:25189701 NCBI chr 8:48,831,894...48,838,399
Ensembl chr 8:48,831,894...48,838,411
JBrowse link
G Ripor1 RHO family interacting cell polarization regulator 1 enables ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:27807006)
(PMID:25588844)
UniProt
Ensembl
RGD
PMID:25588844 PMID:27807006 GO_REF:0000024 GO_REF:0000107 NCBI chr19:33,477,750...33,506,424
Ensembl chr19:33,477,793...33,506,420
JBrowse link
G Ripor2 RHO family interacting cell polarization regulator 2 enables ISO
ISS
(PMID:24687993)
GO_REF:0000024
(PMID:27556504)
RGD
UniProt
PMID:24687993 PMID:27556504 GO_REF:0000024 NCBI chr17:40,323,867...40,547,482
Ensembl chr17:40,323,867...40,548,092
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 enables ISO (PMID:18439900) RGD PMID:18439900 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 enables ISO (PMID:16709803) RGD PMID:16709803 NCBI chr20:3,403,418...3,479,476 JBrowse link
G Sik1 salt-inducible kinase 1 enables ISO
ISS
(PMID:18348280)
GO_REF:0000024
RGD
UniProt
PMID:18348280 GO_REF:0000024 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
JBrowse link
G Srpk2 SRSF protein kinase 2 enables ISO (MGI:5009368|PMID:19592491) RGD PMID:19592491 MGI:5009368 NCBI chr 4:11,464,684...11,655,993
Ensembl chr 4:11,464,674...11,655,990
JBrowse link
G Synpo2 synaptopodin 2 enables ISS
ISO
GO_REF:0000024
(MGI:3768463|PMID:17923693)
UniProt
RGD
PMID:17923693 GO_REF:0000024 MGI:3768463 NCBI chr 2:211,217,099...211,371,267
Ensembl chr 2:211,216,783...211,371,267
JBrowse link
G Tbc1d22a TBC1 domain family, member 22a enables ISO (PMID:23572552) RGD PMID:23572552 NCBI chr 7:117,292,481...117,577,468
Ensembl chr 7:117,292,631...117,577,483
JBrowse link
G Tbc1d22b TBC1 domain family, member 22B enables ISO (PMID:23572552) RGD PMID:23572552 NCBI chr20:7,619,096...7,675,232
Ensembl chr20:7,619,240...7,675,231
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 enables ISO (PMID:27697108) RGD PMID:27697108 NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926
JBrowse link
G Tsc2 TSC complex subunit 2 enables ISO (MGI:3773582|PMID:18198340) RGD PMID:18198340 MGI:3773582 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta IPI RGD PMID:17308302 RGD:1642660 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
JBrowse link
G Zfp36 zinc finger protein 36 enables IEA
ISO
ISS
GO_REF:0000107
(MGI:5795819|PMID:20595389)
GO_REF:0000024
(PMID:15014438)
Ensembl
RGD
UniProt
PMID:15014438 PMID:20595389 GO_REF:0000024 GO_REF:0000107 MGI:5795819 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 enables ISO
ISS
(PMID:15538381), (PMID:18326031)
GO_REF:0000024
RGD
UniProt
PMID:15538381 PMID:18326031 GO_REF:0000024 NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
JBrowse link

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  molecular_function 19910
    binding 16997
      protein binding 14384
        14-3-3 protein binding 33
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