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ONTOLOGY REPORT - ANNOTATIONS

Term:cytoplasm protein quality control by the ubiquitin-proteasome system
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Accession:GO:0071629 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation.
Comment:See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
Synonyms:exact_synonym: cytoplasm-associated proteasomal ubiquitin-dependent protein breakdown;   cytoplasm-associated proteasomal ubiquitin-dependent protein catabolism;   cytoplasm-associated proteasomal ubiquitin-dependent protein degradation;   ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
 only_in_taxon: NCBITaxon:2759 ! Eukaryota


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cytoplasm protein quality control by the ubiquitin-proteasome system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf126 ring finger protein 126 involved_in ISO (PMID:24981174) RGD PMID:24981174 NCBI chr 7:9,939,359...9,946,963
Ensembl chr 7:9,938,229...9,946,738 		JBrowse link
G Ubr4 ubiquitin protein ligase E3 component n-recognin 4 involved_in ISO
ISS		 (PMID:29033132)
GO_REF:0000024		 RGD
UniProt		 PMID:29033132 GO_REF:0000024 NCBI chr 5:151,635,825...151,743,931
Ensembl chr 5:151,635,868...151,743,784 		JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 involved_in ISO
ISS		 (PMID:29033132)
GO_REF:0000024		 RGD
UniProt		 PMID:29033132 GO_REF:0000024 NCBI chr 7:69,115,216...69,224,843
Ensembl chr 7:69,116,761...69,224,903 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    response to stimulus 10920
      cellular response to stimulus 9075
        cellular response to stress 2061
          cellular response to topologically incorrect protein 109
            cellular response to misfolded protein 18
              cytoplasm protein quality control by the ubiquitin-proteasome system 3
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      organic substance metabolic process 11328
        organic substance catabolic process 2402
          organonitrogen compound catabolic process 1594
            protein catabolic process 1116
              proteolysis involved in protein catabolic process 862
                modification-dependent protein catabolic process 683
                  ubiquitin-dependent protein catabolic process 664
                    proteasome-mediated ubiquitin-dependent protein catabolic process 455
                      cytoplasm protein quality control by the ubiquitin-proteasome system 3
paths to the root