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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
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Accession:GO:0071619 term browser browse the term
Definition:The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser2 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans.


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positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNK cyclin K involved_in ISO (PMID:22988298) CACAO PMID:22988298 NCBI chr14:80,105,372...80,136,511
Ensembl chr14:99,438,814...99,480,842
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Term Annotations click to browse term
  biological_process 12650
    metabolic process 7923
      cellular metabolic process 7259
        phosphorus metabolic process 2143
          phosphate-containing compound metabolic process 2131
            phosphorylation 1502
              protein phosphorylation 1340
                phosphorylation of RNA polymerase II C-terminal domain 5
                  phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 1
                    negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 0
                    phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter 0
                    positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 1
                    regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + 1
Path 2
Term Annotations click to browse term
  biological_process 12650
    metabolic process 7923
      cellular metabolic process 7259
        cellular aromatic compound metabolic process 3904
          nucleobase-containing compound metabolic process 3733
            nucleic acid metabolic process 3419
              RNA metabolic process 3030
                RNA biosynthetic process 2447
                  nucleic acid-templated transcription 2436
                    transcription, DNA-templated 2431
                      regulation of transcription, DNA-templated 2355
                        regulation of transcription by RNA polymerase II 1705
                          phosphorylation of RNA polymerase II C-terminal domain 5
                            phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 1
                              negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 0
                              phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter 0
                              positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 1
                              regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + 1
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