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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
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Accession:GO:0071619 term browser browse the term
Definition:The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser2 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans.


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positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnk cyclin K involved_in ISO (PMID:22988298) RGD PMID:22988298 NCBI chr 6:132,090,235...132,113,560
Ensembl chr 6:132,090,218...132,113,557
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Term Annotations click to browse term
  biological_process 19599
    metabolic process 11860
      cellular metabolic process 10814
        phosphorus metabolic process 2862
          phosphate-containing compound metabolic process 2840
            phosphorylation 1968
              protein phosphorylation 1626
                phosphorylation of RNA polymerase II C-terminal domain 13
                  phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 1
                    negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 0
                    phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter 0
                    positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 1
                    regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + 1
Path 2
Term Annotations click to browse term
  biological_process 19599
    metabolic process 11860
      cellular metabolic process 10814
        cellular aromatic compound metabolic process 5628
          nucleobase-containing compound metabolic process 5411
            nucleic acid metabolic process 4921
              RNA metabolic process 4404
                RNA biosynthetic process 3418
                  nucleic acid-templated transcription 3403
                    transcription, DNA-templated 3401
                      regulation of transcription, DNA-templated 3270
                        regulation of transcription by RNA polymerase II 2385
                          phosphorylation of RNA polymerase II C-terminal domain 13
                            phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 1
                              negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 0
                              phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter 0
                              positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 1
                              regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + 1
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