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ONTOLOGY REPORT - ANNOTATIONS

Term:transforming growth factor beta production
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Accession:GO:0071604 term browser browse the term
Definition:The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
Synonyms:exact_synonym: TGF-B production;   TGF-beta production;   TGFb production;   TGFbeta production
 narrow_synonym: transforming growth factor-beta secretion
 alt_id: GO:0038044

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transforming growth factor beta production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V involved_in ISO (MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:5571208 NCBI chrNW_004955403:11,588,536...11,669,809
Ensembl chrNW_004955403:11,592,339...11,659,297 		JBrowse link
G Itgb6 integrin subunit beta 6 involved_in ISO (MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:5571208 NCBI chrNW_004955449:13,387,013...13,520,879
Ensembl chrNW_004955449:13,448,084...13,520,879 		JBrowse link
negative regulation of transforming growth factor beta production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbln1 fibulin 1 involved_in ISO (PMID:25834989) UniProt PMID:25834989 NCBI chrNW_004955413:29,837,134...29,911,313
Ensembl chrNW_004955413:29,837,134...29,912,222 		JBrowse link
G Fn1 fibronectin 1 involved_in ISO (PMID:25834989) UniProt PMID:25834989 NCBI chrNW_004955457:629,599...694,948
Ensembl chrNW_004955457:629,518...696,975 		JBrowse link
G Il13 interleukin 13 ISO RGD PMID:20100461 RGD:4145466 NCBI chrNW_004955408:4,046,406...4,049,795 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:23994610) MGI PMID:23994610 NCBI chrNW_004955432:22,440,671...22,519,592
Ensembl chrNW_004955432:22,440,637...22,517,647 		JBrowse link
negative regulation of transforming growth factor beta1 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd2ap CD2 associated protein acts_upstream_of_or_within ISO (PMID:21911934) MGI PMID:21911934 NCBI chrNW_004955437:12,005,399...12,087,014
Ensembl chrNW_004955437:11,983,311...12,091,100 		JBrowse link
G Furin furin, paired basic amino acid cleaving enzyme involved_in ISO (PMID:15899807) BHF-UCL PMID:15899807 NCBI chrNW_004955416:14,915,031...14,947,634
Ensembl chrNW_004955416:14,936,546...14,949,252 		JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta involved_in ISO (PMID:26126825) UniProt PMID:26126825 NCBI chrNW_004955417:13,574,493...13,625,669
Ensembl chrNW_004955417:13,574,721...13,625,313 		JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan involved_in ISO (MGI:6478057|PMID:25159578) UniProt PMID:25159578 MGI:6478057 NCBI chrNW_004955414:15,166,349...15,178,284
Ensembl chrNW_004955414:15,166,349...15,178,284 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP involved_in ISO (MGI:5638298|PMID:25690660) ARUK-UCL PMID:25690660 MGI:5638298 NCBI chrNW_004955468:2,673,657...2,677,633
Ensembl chrNW_004955468:2,673,980...2,677,321 		JBrowse link
negative regulation of transforming growth factor beta3 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule involved_in ISO (PMID:16930538) UniProt PMID:16930538 NCBI chrNW_004955411:32,270,881...32,275,236
Ensembl chrNW_004955411:32,270,881...32,275,236 		JBrowse link
positive regulation of transforming growth factor beta production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) UniProt PMID:12540904 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Fermt1 FERM domain containing kindlin 1 involved_in ISO (MGI:5571208|PMID:24681597) CAFA PMID:24681597 MGI:5571208 NCBI chrNW_004955415:16,447,921...16,483,221
Ensembl chrNW_004955415:16,446,934...16,483,369 		JBrowse link
G Ifnb1 interferon beta 1 ISO RGD PMID:10494101 RGD:401854240 NCBI chrNW_004955434:23,301,623...23,302,304 JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
G Myb MYB proto-oncogene, transcription factor ISO RGD PMID:15534927 RGD:11532676 NCBI chrNW_004955439:1,523,516...1,560,185
Ensembl chrNW_004955439:1,521,292...1,560,220 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in ISO PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171 		JBrowse link
G Serpinf2 serpin family F member 2 involved_in ISO (PMID:17958745), (PMID:20008146)
(MGI:5306295|PMID:17958745)		 BHF-UCL PMID:17958745 PMID:20008146 MGI:5306295 NCBI chrNW_004955481:1,441,262...1,449,078
Ensembl chrNW_004955481:1,442,010...1,449,242 		JBrowse link
G Thbs1 thrombospondin 1 ISO RGD PMID:17640965 RGD:2317942 NCBI chrNW_004955416:6,490,034...6,506,419
Ensembl chrNW_004955416:6,489,451...6,506,419 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:18832695) BHF-UCL PMID:18832695 NCBI chrNW_004955462:8,594,416...8,598,101 JBrowse link
positive regulation of transforming growth factor beta1 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO (PMID:16374430) HGNC-UCL PMID:16374430 NCBI chrNW_004955565:2,006,154...2,029,921 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 acts_upstream_of_or_within ISO (PMID:18097059) MGI PMID:18097059 NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:17028180) MGI PMID:17028180 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
G Lum lumican involved_in ISO (MGI:5295830|PMID:21931815) CACAO PMID:21931815 MGI:5295830 NCBI chrNW_004955405:28,299,966...28,307,982
Ensembl chrNW_004955405:28,298,988...28,308,054 		JBrowse link
G Serpinb7 serpin family B member 7 ISO RGD PMID:21945418 RGD:7207383 NCBI chrNW_004955402:47,599,503...47,649,537
Ensembl chrNW_004955402:47,599,150...47,649,885 		JBrowse link
positive regulation of transforming growth factor beta2 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 acts_upstream_of_or_within ISO (PMID:17767158) MGI PMID:17767158 NCBI chrNW_004955449:332,563...411,218
Ensembl chrNW_004955449:338,193...411,218 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO (MGI:2175930|PMID:11854453) BHF-UCL PMID:11854453 MGI:2175930 NCBI chrNW_004955510:5,812,571...5,936,312
Ensembl chrNW_004955510:5,905,008...5,936,312 		JBrowse link
G Wnt11 Wnt family member 11 acts_upstream_of_or_within ISO (PMID:17767158) MGI PMID:17767158 NCBI chrNW_004955414:15,674,478...15,694,758
Ensembl chrNW_004955414:15,674,940...15,694,883 		JBrowse link
positive regulation of transforming growth factor beta3 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:16891311 PMID:21308733 RGD:10059386 RGD:1625706 NCBI chrNW_004955457:7,424,403...7,490,630
Ensembl chrNW_004955457:7,431,736...7,491,149 		JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:16891311 RGD:1625706 NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136 		JBrowse link
regulation of transforming growth factor beta2 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004955466:8,000,311...8,022,497
Ensembl chrNW_004955466:8,000,044...8,022,497 		JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136 		JBrowse link
G Smad4 SMAD family member 4 involved_in ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004955402:35,956,080...36,001,746
Ensembl chrNW_004955402:35,961,165...35,994,538 		JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in ISO (PMID:12411310) BHF-UCL PMID:12411310 NCBI chrNW_004955406:174,949...249,248
Ensembl chrNW_004955406:172,814...249,248 		JBrowse link
transforming growth factor beta1 production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd2ap CD2 associated protein acts_upstream_of ISO (PMID:21911934) MGI PMID:21911934 NCBI chrNW_004955437:12,005,399...12,087,014
Ensembl chrNW_004955437:11,983,311...12,091,100 		JBrowse link
G Col3a1 collagen type III alpha 1 chain involved_in ISO (PMID:24820199) MGI PMID:24820199 NCBI chrNW_004955403:9,720,831...9,758,019
Ensembl chrNW_004955403:9,721,114...9,757,887 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of ISO (PMID:17028180) MGI PMID:17028180 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    multicellular organismal process 6182
      cytokine production 702
        transforming growth factor beta production 35
          negative regulation of transforming growth factor beta production + 10
          positive regulation of transforming growth factor beta production + 19
          regulation of transforming growth factor beta production + 32
          transforming growth factor beta1 production + 11
          transforming growth factor beta2 production + 7
          transforming growth factor beta3 production + 3
Path 2
Term Annotations click to browse term
  biological_process 12346
    metabolic process 7467
      organic substance metabolic process 7146
        macromolecule metabolic process 6003
          macromolecule biosynthetic process 4614
            gene expression 4278
              cytokine production 702
                transforming growth factor beta production 35
                  negative regulation of transforming growth factor beta production + 10
                  positive regulation of transforming growth factor beta production + 19
                  regulation of transforming growth factor beta production + 32
                  transforming growth factor beta1 production + 11
                  transforming growth factor beta2 production + 7
                  transforming growth factor beta3 production + 3
paths to the root