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ONTOLOGY REPORT - ANNOTATIONS

Term:transforming growth factor beta production
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Accession:GO:0071604 term browser browse the term
Definition:The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
Synonyms:exact_synonym: TGF-B production;   TGF-beta production;   TGFb production;   TGFbeta production
 narrow_synonym: transforming growth factor-beta secretion
 alt_id: GO:0038044

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transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V ISO
IEA		 (MGI:5571208|PMID:24681597)
GO_REF:0000107		 RGD
Ensembl		 PMID:24681597 GO_REF:0000107 MGI:5571208 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411 		JBrowse link
G Itgb6 integrin subunit beta 6 ISO
IEA		 (MGI:5571208|PMID:24681597)
GO_REF:0000107		 RGD
Ensembl		 PMID:24681597 GO_REF:0000107 MGI:5571208 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958 		JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B ISO RGD DOI:10.1016/j.procbio.2011.10.027 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO
ISS		 (PMID:20599762)
GO_REF:0000024		 RGD
UniProt		 PMID:20599762 GO_REF:0000024 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243 		JBrowse link
negative regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbln1 fibulin 1 ISO (PMID:25834989) RGD PMID:25834989 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468 		JBrowse link
G Fn1 fibronectin 1 ISO
IEA		 (PMID:25834989)
GO_REF:0000107		 RGD
Ensembl		 PMID:25834989 GO_REF:0000107 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Il13 interleukin 13 IDA RGD PMID:20100461 RGD:4145466 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO MGI:3041135 (MGI:5529574|PMID:23994610) RGD PMID:23994610 MGI:5529574 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665 		JBrowse link
G Mir125a microRNA 125a IDA RGD PMID:29700287 RGD:26884455 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911 		JBrowse link
negative regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:11583628) RGD PMID:11583628 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724 		JBrowse link
negative regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd2ap CD2-associated protein ISO MGI:98725 (MGI:5297732|PMID:21911934) RGD PMID:21911934 MGI:5297732 NCBI chr 9:20,794,680...20,858,438
Ensembl chr 9:20,765,296...20,858,504 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO
IEA		 (PMID:15899807)
GO_REF:0000107		 RGD
Ensembl		 PMID:15899807 GO_REF:0000107 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182 		JBrowse link
G Gata6 GATA binding protein 6 IEA
ISO		 GO_REF:0000107
(PMID:21127043)		 Ensembl
RGD		 PMID:21127043 GO_REF:0000107 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338 		JBrowse link
G Laptm4b lysosomal protein transmembrane 4 beta ISO
ISS		 (PMID:26126825)
GO_REF:0000024		 RGD
UniProt		 PMID:26126825 GO_REF:0000024 NCBI chr 7:72,924,911...72,968,099
Ensembl chr 7:72,924,799...72,968,101 		JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan ISS
ISO
IEA		 GO_REF:0000024
(MGI:6478057|PMID:25159578)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:25159578 GO_REF:0000024 GO_REF:0000107 MGI:6478057 NCBI chr 1:163,317,281...163,328,697
Ensembl chr 1:163,317,282...163,328,591 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp ISO
IBA		 (MGI:5638298|PMID:25690660)
PMID:21873635		 RGD PMID:25690660, PMID:21873635 MGI:5638298, RGD:13792537 NCBI chr 1:88,875,370...88,879,305
Ensembl chr 1:88,875,375...88,879,303 		JBrowse link
negative regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh3 cadherin 3 ISO (PMID:22696062) RGD PMID:22696062 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677 		JBrowse link
G Gata6 GATA binding protein 6 IEA
ISO		 GO_REF:0000107
(PMID:21127043)		 Ensembl
RGD		 PMID:21127043 GO_REF:0000107 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338 		JBrowse link
negative regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule ISO
ISS		 (PMID:16930538)
GO_REF:0000024		 RGD
UniProt		 PMID:16930538, PMID:16930538 GO_REF:0000024, RGD:8553566 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846 		JBrowse link
positive regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 ISO
IEA		 (PMID:33082341)
GO_REF:0000107		 RGD
Ensembl		 PMID:33082341 GO_REF:0000107 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338 		JBrowse link
positive regulation of transforming growth factor beta production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd200 Cd200 molecule IEA
ISO		 GO_REF:0000107
UniProtKB:P21272 (PMID:26670206)		 Ensembl
RGD		 PMID:26670206 GO_REF:0000107 NCBI chr11:60,371,617...60,398,450
Ensembl chr11:60,371,684...60,403,196 		JBrowse link
G Cd34 CD34 molecule ISO
ISS		 (PMID:17505307)
GO_REF:0000024		 RGD
UniProt		 PMID:17505307 GO_REF:0000024 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647 		JBrowse link
G Cd46 CD46 molecule ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995 		JBrowse link
G Fermt1 fermitin family member 1 ISO
IEA		 (MGI:5571208|PMID:24681597)
GO_REF:0000107		 RGD
Ensembl		 PMID:24681597 GO_REF:0000107 MGI:5571208 NCBI chr 3:125,566,744...125,607,864
Ensembl chr 3:125,566,643...125,607,735 		JBrowse link
G Lgals9 galectin 9 ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201 		JBrowse link
G Myb MYB proto-oncogene, transcription factor IMP RGD PMID:15534927 RGD:11532676 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP PMID:9630216 BHF-UCL PMID:9630216 RGD:5135054 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Serpinf2 serpin family F member 2 ISO (PMID:17958745), (PMID:20008146)
(MGI:5306295|PMID:17958745)		 RGD PMID:17958745 PMID:20008146 MGI:5306295 NCBI chr10:62,264,247...62,272,353
Ensembl chr10:62,264,788...62,273,119 		JBrowse link
G Thbs1 thrombospondin 1 IMP RGD PMID:17640965 RGD:2317942 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 ISO (PMID:18832695) RGD PMID:18832695 NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864 		JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Furin furin (paired basic amino acid cleaving enzyme) ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:7737999)		 UniProt
Ensembl
RGD		 PMID:7737999 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182 		JBrowse link
positive regulation of transforming growth factor beta1 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 ISO (PMID:16374430) RGD PMID:16374430 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEA
ISO		 GO_REF:0000107
MGI:3608773 (MGI:3772530|PMID:18097059)		 Ensembl
RGD		 PMID:18097059 GO_REF:0000107 MGI:3772530 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800 		JBrowse link
G Foxp3 forkhead box P3 ISO (MGI:3697020|PMID:17028180) RGD PMID:17028180 MGI:3697020 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522 		JBrowse link
G Lum lumican ISO (MGI:5295830|PMID:21931815) RGD PMID:21931815 MGI:5295830 NCBI chr 7:38,820,058...38,826,862
Ensembl chr 7:38,819,771...38,826,862 		JBrowse link
G Serpinb7 serpin family B member 7 IMP RGD PMID:21945418 RGD:7207383 NCBI chr13:27,282,456...27,354,775
Ensembl chr13:27,312,498...27,354,052 		JBrowse link
positive regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 ISO MGI:1857283 (MGI:3759355|PMID:17767158) RGD PMID:17767158 MGI:3759355 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951 		JBrowse link
G Wnt11 Wnt family member 11 ISO MGI:2665014 (MGI:3759355|PMID:17767158) RGD PMID:17767158 MGI:3759355 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756 		JBrowse link
positive regulation of transforming growth factor beta3 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 IMP RGD PMID:16891311, PMID:21308733 RGD:1625706, RGD:10059386 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Smad3 SMAD family member 3 IMP RGD PMID:16891311 RGD:1625706 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V ISO (PMID:22278742) RGD PMID:22278742 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411 		JBrowse link
G Itgb6 integrin subunit beta 6 ISS
ISO		 GO_REF:0000024
(PMID:22278742)		 UniProt
RGD		 PMID:22278742 GO_REF:0000024 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958 		JBrowse link
G Itgb8 integrin subunit beta 8 ISO (MGI:5490445|PMID:22278742) RGD PMID:22278742 MGI:5490445 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813 		JBrowse link
G Lrrc32 leucine rich repeat containing 32 ISO (PMID:19651619), (PMID:19750484), (PMID:22278742) RGD PMID:19651619 PMID:19750484 PMID:22278742 NCBI chr 1:163,443,972...163,457,426
Ensembl chr 1:163,445,527...163,457,424 		JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 ISS
ISO
IEA		 GO_REF:0000024
(PMID:2022183), (PMID:8617200)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:2022183 PMID:8617200 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:21,203,502...21,600,441
Ensembl chr 6:21,203,502...21,600,451 		JBrowse link
regulation of transforming growth factor beta2 production term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha ISO
IEA		 (PMID:12411310)
GO_REF:0000107		 RGD
Ensembl		 PMID:12411310 GO_REF:0000107 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Smad3 SMAD family member 3 ISO (PMID:12411310) RGD PMID:12411310 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Smad4 SMAD family member 4 ISO
IEA		 (PMID:12411310)
GO_REF:0000107		 RGD
Ensembl		 PMID:12411310 GO_REF:0000107 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO
ISS		 (PMID:12411310)
GO_REF:0000024		 RGD
UniProt		 PMID:12411310 GO_REF:0000024 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc32 leucine rich repeat containing 32 ISO (MGI:5920420|PMID:28912269) RGD PMID:28912269 MGI:5920420 NCBI chr 1:163,443,972...163,457,426
Ensembl chr 1:163,445,527...163,457,424 		JBrowse link
transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO (PMID:18672106) RGD PMID:18672106 NCBI chr 1:221,099,155...221,116,096
Ensembl chr 1:221,099,998...221,116,096 		JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrros negative regulator of reactive oxygen species ISS
ISO		 GO_REF:0000024
(MGI:6192878|PMID:29909984)		 UniProt
RGD		 PMID:29909984 GO_REF:0000024 MGI:6192878 NCBI chr11:71,872,728...71,889,897
Ensembl chr11:71,872,830...71,889,887 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20045
    multicellular organismal process 9042
      cytokine production 740
        transforming growth factor beta production 45
          negative regulation of transforming growth factor beta production + 16
          positive regulation of transforming growth factor beta production + 21
          regulation of transforming growth factor beta production + 43
          transforming growth factor beta activation + 12
          transforming growth factor beta1 production + 13
          transforming growth factor beta2 production + 8
          transforming growth factor beta3 production + 4
Path 2
Term Annotations click to browse term
  biological_process 20045
    metabolic process 12102
      organic substance metabolic process 11623
        macromolecule metabolic process 10034
          gene expression 6359
            cytokine production 740
              transforming growth factor beta production 45
                negative regulation of transforming growth factor beta production + 16
                positive regulation of transforming growth factor beta production + 21
                regulation of transforming growth factor beta production + 43
                transforming growth factor beta activation + 12
                transforming growth factor beta1 production + 13
                transforming growth factor beta2 production + 8
                transforming growth factor beta3 production + 4
paths to the root