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ONTOLOGY REPORT - ANNOTATIONS


Term:histone H3K27me2/H3K27me3 demethylase activity
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Accession:GO:0071558 term browser browse the term
Definition:Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
Synonyms:exact_synonym: histone H3-tri/di-methyl-lysine-27 demethylase activity
 broad_synonym: histone demethylase activity (H3-K27 specific)
 related_synonym: histone H3K27me2 demethylase activity;   histone H3K27me3 demethylase activity
 xref: EC:1.14.11.68;   RHEA:60224;   Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter";   Reactome:R-HSA-9822914 "KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)";   Reactome:R-HSA-9822985 "KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)";   reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin";   reactome:R-HSA-5617887 "HOXC4 chromatin is activated"



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histone H3K27me2/H3K27me3 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm6a lysine demethylase 6A enables IBA
ISO
GO_REF:0000033
(PMID:22949634)
GO_Central
RGD
PMID:22949634 GO_REF:0000033 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062
JBrowse link
G Kdm6b lysine demethylase 6B enables ISO
IBA
(PMID:28262558)
(PMID:17928865), (PMID:18716661), (PMID:23856522)
GO_REF:0000033
RGD
GO_Central
PMID:17928865 PMID:18716661 PMID:23856522 PMID:28262558 GO_REF:0000033 NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
JBrowse link
G Kdm7a lysine demethylase 7A enables ISO (PMID:20023638), (PMID:20194436), (PMID:20622853)
(PMID:20194436)
RGD PMID:20023638 PMID:20194436 PMID:20622853 NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998
JBrowse link
G Phf8 PHD finger protein 8 enables ISO (PMID:20622853), (PMID:20622854) RGD PMID:20622853 PMID:20622854 NCBI chr  X:20,524,103...20,623,459
Ensembl chr  X:20,524,558...20,623,410
JBrowse link
G Uty ubiquitously transcribed tetratricopeptide repeat containing, Y-linked enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  Y:942,838...1,105,313
Ensembl chr  Y:924,168...1,103,422
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21088
    catalytic activity 6122
      oxidoreductase activity 868
        dioxygenase activity 100
          2-oxoglutarate-dependent dioxygenase activity 64
            histone H3K27me2/H3K27me3 demethylase activity 5
Path 2
Term Annotations click to browse term
  molecular_function 21088
    catalytic activity 6122
      demethylase activity 42
        protein demethylase activity 30
          histone demethylase activity 30
            histone H3 demethylase activity 26
              histone H3K27me2/H3K27me3 demethylase activity 5
paths to the root