ONTOLOGY REPORT - ANNOTATIONS
Term: histone H3K27me2/H3K27me3 demethylase activity
Accession: GO:0071558
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Definition: Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
Synonyms: exact_synonym: histone H3-tri/di-methyl-lysine-27 demethylase activity
broad_synonym: histone demethylase activity (H3-K27 specific)
related_synonym: histone H3K27me2 demethylase activity; histone H3K27me3 demethylase activity
xref: EC:1.14.11.68; RHEA:60224; Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter"; Reactome:R-HSA-9822914 "KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3)"; Reactome:R-HSA-9822985 "KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)"; reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin"; reactome:R-HSA-5617887 "HOXC4 chromatin is activated"
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Kdm6a
lysine demethylase 6A
enables
IBA ISO
GO_REF:0000033 (PMID:22949634)
GO_Central RGD
PMID:22949634
GO_REF:0000033
NCBI chr X:4,337,466...4,477,100
Ensembl chr X:4,337,750...4,477,062
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Kdm6b
lysine demethylase 6B
enables
ISO IBA
(PMID:28262558) (PMID:17928865), (PMID:18716661), (PMID:23856522) GO_REF:0000033
RGD GO_Central
PMID:17928865 PMID:18716661 PMID:23856522 PMID:28262558
GO_REF:0000033
NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
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Kdm7a
lysine demethylase 7A
enables
ISO
(PMID:20023638), (PMID:20194436), (PMID:20622853) (PMID:20194436)
RGD
PMID:20023638 PMID:20194436 PMID:20622853
NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998
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Phf8
PHD finger protein 8
enables
ISO
(PMID:20622853), (PMID:20622854)
RGD
PMID:20622853 PMID:20622854
NCBI chr X:20,524,103...20,623,459
Ensembl chr X:20,524,558...20,623,410
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Uty
ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr Y:942,838...1,105,313
Ensembl chr Y:924,168...1,103,422
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