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ONTOLOGY REPORT - ANNOTATIONS


Term:death-inducing signaling complex assembly
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Accession:GO:0071550 term browser browse the term
Definition:A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway.
Synonyms:exact_synonym: DD-mediated complex assembly;   DISC assembly;   DISC formation;   death domain-mediated complex assembly;   death domain-mediated complex assembly involved in extrinsic apoptotic pathway;   death-inducing signaling complex formation;   death-inducing signalling complex assembly



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death-inducing signaling complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain involved_in ISO (PMID:24025841) RGD PMID:24025841 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2388026 (PMID:16365167)
Ensembl
RGD
PMID:16365167 GO_REF:0000107 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
negative regulation of death-inducing signaling complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nol3 nucleolar protein 3 involved_in IDA PMID:12191471
PMID:15383280
UniProt PMID:12191471 PMID:15383280 RGD:631884, RGD:10047289 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19872
    cellular process 18312
      signal transduction 7039
        apoptotic signaling pathway 668
          extrinsic apoptotic signaling pathway 242
            death-inducing signaling complex assembly 3
              TRAIL death-inducing signaling complex assembly 0
              negative regulation of death-inducing signaling complex assembly 1
              regulation of death-inducing signaling complex assembly + 1
Path 2
Term Annotations click to browse term
  biological_process 19872
    biological regulation 13396
      regulation of biological process 12998
        regulation of cellular process 12446
          signal transduction 7039
            apoptotic signaling pathway 668
              extrinsic apoptotic signaling pathway 242
                death-inducing signaling complex assembly 3
                  TRAIL death-inducing signaling complex assembly 0
                  negative regulation of death-inducing signaling complex assembly 1
                  regulation of death-inducing signaling complex assembly + 1
paths to the root