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ONTOLOGY REPORT - ANNOTATIONS

Term:dopaminergic neuron differentiation
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Accession:GO:0071542 term browser browse the term
Definition:The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.

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dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl12 C-X-C motif chemokine ligand 12 involved_in ISO (MGI:5700491|PMID:22535492) ParkinsonsUK-UCL PMID:22535492 MGI:5700491 NCBI chrNW_004955546:1,929,269...1,941,690
Ensembl chrNW_004955546:1,929,269...1,941,690 		JBrowse link
G Dmrta2 DMRT like family A2 acts_upstream_of_or_within ISO (PMID:21576465) MGI PMID:21576465 NCBI chrNW_004955464:8,493,392...8,498,007
Ensembl chrNW_004955464:8,495,055...8,497,909 		JBrowse link
G En1 engrailed homeobox 1 acts_upstream_of_or_within ISO (PMID:15175251), (PMID:15340832) MGI PMID:15175251 PMID:15340832 NCBI chrNW_004955459:10,839,581...10,844,198 JBrowse link
G En2 engrailed homeobox 2 acts_upstream_of_or_within ISO (PMID:15175251), (PMID:15340832) MGI PMID:15175251 PMID:15340832 NCBI chrNW_004955491:8,422,295...8,427,038 JBrowse link
G Fgf8 fibroblast growth factor 8 involved_in ISO (PMID:15193767) UniProt PMID:15193767 NCBI chrNW_004955485:8,517,412...8,521,732
Ensembl chrNW_004955485:8,517,412...8,521,770 		JBrowse link
G Foxa1 forkhead box A1 acts_upstream_of ISO (PMID:17596284) MGI PMID:17596284 NCBI chrNW_004955409:23,598,127...23,599,827
Ensembl chrNW_004955409:23,598,127...23,599,461 		JBrowse link
G Foxa2 forkhead box A2 involved_in
acts_upstream_of_or_within		 ISO (PMID:19951692)
(PMID:18076286)
(PMID:17596284)		 ParkinsonsUK-UCL
MGI		 PMID:17596284 PMID:18076286 PMID:19951692 NCBI chrNW_004955415:29,982,940...29,987,093
Ensembl chrNW_004955415:29,982,940...29,986,255 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within ISO (PMID:17215402) MGI PMID:17215402 NCBI chrNW_004955466:8,000,311...8,022,497
Ensembl chrNW_004955466:8,000,044...8,022,497 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 acts_upstream_of_or_within ISO (PMID:11297820) MGI PMID:11297820 NCBI chrNW_004955473:462,940...510,006 JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 ISO RGD PMID:17443768 RGD:6480676 NCBI chrNW_004955425:2,321,420...2,420,420
Ensembl chrNW_004955425:2,321,420...2,420,530 		JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of ISO (PMID:19109490) MGI PMID:19109490 NCBI chrNW_004955487:878,326...880,783
Ensembl chrNW_004955487:878,326...880,783 		JBrowse link
G L1cam L1 cell adhesion molecule ISO RGD PMID:1350253 RGD:11570519 NCBI chrNW_004955580:548,442...561,580
Ensembl chrNW_004955580:549,368...561,486 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha acts_upstream_of_or_within ISO (PMID:21752929), (PMID:24066094) MGI PMID:21752929 PMID:24066094 NCBI chrNW_004955462:11,328,583...11,484,438
Ensembl chrNW_004955462:11,329,676...11,477,770 		JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta involved_in
acts_upstream_of_or_within		 ISO (MGI:5705221|PMID:19951692)
(PMID:21752929)		 ParkinsonsUK-UCL
MGI		 PMID:19951692 PMID:21752929 MGI:5705221 NCBI chrNW_004955419:1,782,566...1,857,375
Ensembl chrNW_004955419:1,782,566...1,857,375 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (PMID:19795519) MGI PMID:19795519 NCBI chrNW_004955413:9,080,901...9,237,644
Ensembl chrNW_004955413:9,080,914...9,237,650 		JBrowse link
G Neurog2 neurogenin 2 acts_upstream_of_or_within ISO (PMID:16396906) MGI PMID:16396906 NCBI chrNW_004955457:14,268,078...14,287,050 JBrowse link
G Nr4a2 nuclear receptor subfamily 4 group A member 2 involved_in
acts_upstream_of_or_within		 ISO (MGI:3830409|PMID:19144721)
(PMID:14622207), (PMID:9520484)
(PMID:11113533)		 UniProt
MGI		 PMID:9520484 PMID:11113533 PMID:14622207 PMID:19144721 MGI:3830409 NCBI chrNW_004955449:16,928,780...16,944,536
Ensembl chrNW_004955449:16,937,794...16,945,731 		JBrowse link
G Otp orthopedia homeobox acts_upstream_of_or_within ISO (PMID:17481897) MGI PMID:17481897 NCBI chrNW_004955425:23,350,449...23,358,189
Ensembl chrNW_004955425:23,350,449...23,358,189 		JBrowse link
G Otx2 orthodenticle homeobox 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:19951692)
(PMID:15888661)		 ParkinsonsUK-UCL
MGI		 PMID:15888661 PMID:19951692 NCBI chrNW_004955466:10,755,143...10,764,957
Ensembl chrNW_004955466:10,755,012...10,765,095 		JBrowse link
G Phox2b paired like homeobox 2B involved_in ISO (MGI:1337891|PMID:10360575) BHF-UCL PMID:10360575 MGI:1337891 NCBI chrNW_004955443:5,935,975...5,938,747
Ensembl chrNW_004955443:5,935,975...5,938,747 		JBrowse link
G Pitx3 paired like homeodomain 3 involved_in ISO (MGI:3582099|PMID:15950611)
(MGI:3830409|PMID:19144721)		 UniProt PMID:15950611 PMID:19144721 MGI:3582099 MGI:3830409 NCBI chrNW_004955485:8,130,244...8,140,292
Ensembl chrNW_004955485:8,130,244...8,140,292 		JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (PMID:18953410) MGI PMID:18953410 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351 		JBrowse link
G Rspo2 R-spondin 2 acts_upstream_of_or_within ISO (PMID:24066094) MGI PMID:24066094 NCBI chrNW_004955417:30,643,554...30,704,497
Ensembl chrNW_004955417:30,643,554...30,704,497 		JBrowse link
G Sfrp1 secreted frizzled related protein 1 involved_in ISO (MGI:5700491|PMID:22535492) ParkinsonsUK-UCL PMID:22535492 MGI:5700491 NCBI chrNW_004955536:1,663,721...1,702,678
Ensembl chrNW_004955536:1,663,344...1,703,514 		JBrowse link
G Smo smoothened, frizzled class receptor acts_upstream_of_or_within ISO (PMID:16571630) MGI PMID:16571630 NCBI chrNW_004955479:9,963,377...9,991,670
Ensembl chrNW_004955479:9,964,170...9,993,165 		JBrowse link
G Tshr thyroid stimulating hormone receptor acts_upstream_of_or_within ISO (PMID:10575115) MGI PMID:10575115 NCBI chrNW_004955438:4,601,765...4,758,922
Ensembl chrNW_004955438:4,614,584...4,761,582 		JBrowse link
G Vegfa vascular endothelial growth factor A acts_upstream_of_or_within ISO (PMID:17215402) MGI PMID:17215402 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
G Vegfd vascular endothelial growth factor D involved_in ISO (MGI:5700491|PMID:22535492) ParkinsonsUK-UCL PMID:22535492 MGI:5700491 NCBI chrNW_004955519:2,813,475...2,845,856
Ensembl chrNW_004955519:2,813,438...2,845,915 		JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (MGI:5469218|PMID:23324743) CACAO PMID:23324743 MGI:5469218 NCBI chrNW_004955500:7,797,063...7,811,142
Ensembl chrNW_004955500:7,797,060...7,811,167 		JBrowse link
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within		 ISO (MGI:5469218|PMID:23324743)
(PMID:18953410)		 CACAO
MGI		 PMID:18953410 PMID:23324743 MGI:5469218 NCBI chrNW_004955430:5,304,817...5,325,684
Ensembl chrNW_004955430:5,304,745...5,325,684 		JBrowse link
midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csnk1d casein kinase 1 delta involved_in ISO (MGI:3707948|PMID:17244647) ParkinsonsUK-UCL PMID:17244647 MGI:3707948 NCBI chrNW_004955506:904,659...936,293
Ensembl chrNW_004955506:904,660...935,330 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in ISO (MGI:3836885|PMID:19122665) ParkinsonsUK-UCL PMID:19122665 MGI:3836885 NCBI chrNW_004955420:29,030,716...29,047,447
Ensembl chrNW_004955420:29,030,716...29,047,449 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha involved_in ISO (MGI:5705221|PMID:19951692) ParkinsonsUK-UCL PMID:19951692 MGI:5705221 NCBI chrNW_004955462:11,328,583...11,484,438
Ensembl chrNW_004955462:11,329,676...11,477,770 		JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (MGI:3829860|PMID:18953410), (MGI:5466648|PMID:23109420) ParkinsonsUK-UCL PMID:18953410 PMID:23109420 MGI:3829860 MGI:5466648 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351 		JBrowse link
G Ryk receptor like tyrosine kinase involved_in ISO (MGI:5707582|PMID:23517308) ParkinsonsUK-UCL PMID:23517308 MGI:5707582 NCBI chrNW_004955501:4,360,051...4,419,083
Ensembl chrNW_004955501:4,328,682...4,419,307 		JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (MGI:5469218|PMID:23324743)
(MGI:5705221|PMID:19951692)		 ParkinsonsUK-UCL PMID:19951692 PMID:23324743 MGI:5469218 MGI:5705221 NCBI chrNW_004955500:7,797,063...7,811,142
Ensembl chrNW_004955500:7,797,060...7,811,167 		JBrowse link
G Wnt2 Wnt family member 2 involved_in ISO (PMID:20018874) ParkinsonsUK-UCL PMID:20018874 NCBI chrNW_004955432:22,988,208...23,024,530
Ensembl chrNW_004955432:22,984,170...23,027,705 		JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO (MGI:3829860|PMID:18953410)
(MGI:2679774|PMID:14557550), (MGI:5700308|PMID:15748172), (MGI:5707582|PMID:23517308)
(MGI:5469218|PMID:23324743)		 ParkinsonsUK-UCL PMID:14557550 PMID:15748172 PMID:18953410 PMID:23324743 PMID:23517308 MGI:2679774 MGI:3829860 MGI:5469218 MGI:5700308 MGI:5707582 NCBI chrNW_004955430:5,304,817...5,325,684
Ensembl chrNW_004955430:5,304,745...5,325,684 		JBrowse link
G Wnt9b Wnt family member 9B involved_in ISO (PMID:25640183) ParkinsonsUK-UCL PMID:25640183 NCBI chrNW_004955478:10,816,405...10,841,416
Ensembl chrNW_004955478:10,816,405...10,841,416 		JBrowse link
negative regulation of dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:15522889 RGD:10045566 NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137 		JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (PMID:19109490) MGI PMID:19109490 NCBI chrNW_004955487:878,326...880,783
Ensembl chrNW_004955487:878,326...880,783 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISO (MGI:3836885|PMID:19122665) ParkinsonsUK-UCL PMID:19122665 MGI:3836885 NCBI chrNW_004955491:8,647,133...8,657,381 JBrowse link
G Wnt3a Wnt family member 3A involved_in ISO (MGI:2679774|PMID:14557550) ParkinsonsUK-UCL PMID:14557550 MGI:2679774 NCBI chrNW_004955581:351,375...382,541
Ensembl chrNW_004955581:350,889...382,541 		JBrowse link
positive regulation of dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxa1 forkhead box A1 acts_upstream_of_or_within ISO (PMID:17596284) MGI PMID:17596284 NCBI chrNW_004955409:23,598,127...23,599,827
Ensembl chrNW_004955409:23,598,127...23,599,461 		JBrowse link
G Foxa2 forkhead box A2 acts_upstream_of_or_within ISO (PMID:17596284) MGI PMID:17596284 NCBI chrNW_004955415:29,982,940...29,987,093
Ensembl chrNW_004955415:29,982,940...29,986,255 		JBrowse link
positive regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (MGI:4948425|PMID:21347250) ParkinsonsUK-UCL PMID:21347250 MGI:4948425 NCBI chrNW_004955425:7,353,964...7,357,599 JBrowse link
regulation of dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ferd3l Fer3 like bHLH transcription factor acts_upstream_of_or_within ISO (PMID:20460368) MGI PMID:20460368 NCBI chrNW_004955410:22,034,413...22,034,978
Ensembl chrNW_004955410:22,034,413...22,034,907 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 involved_in ISO (MGI:5466648|PMID:23109420) ParkinsonsUK-UCL PMID:23109420 MGI:5466648 NCBI chrNW_004955407:30,804,769...31,178,420
Ensembl chrNW_004955407:30,803,653...30,942,854 		JBrowse link
regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sfrp1 secreted frizzled related protein 1 involved_in ISO (MGI:5448935|PMID:22290867) ParkinsonsUK-UCL PMID:22290867 MGI:5448935 NCBI chrNW_004955536:1,663,721...1,702,678
Ensembl chrNW_004955536:1,663,344...1,703,514 		JBrowse link
G Sfrp2 secreted frizzled related protein 2 involved_in ISO (MGI:5448935|PMID:22290867) ParkinsonsUK-UCL PMID:22290867 MGI:5448935 NCBI chrNW_004955471:8,103,937...8,112,596
Ensembl chrNW_004955471:8,103,783...8,112,321 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    cellular process 11480
      cellular developmental process 3877
        cell differentiation 3876
          neuron differentiation 1502
            dopaminergic neuron differentiation 42
              midbrain dopaminergic neuron differentiation + 12
              negative regulation of dopaminergic neuron differentiation + 4
              positive regulation of dopaminergic neuron differentiation + 3
              regulation of dopaminergic neuron differentiation + 11
Path 2
Term Annotations click to browse term
  biological_process 12346
    developmental process 5853
      anatomical structure development 5540
        multicellular organism development 4550
          system development 3953
            nervous system development 2463
              neurogenesis 1825
                generation of neurons 1573
                  neuron differentiation 1502
                    dopaminergic neuron differentiation 42
                      midbrain dopaminergic neuron differentiation + 12
                      negative regulation of dopaminergic neuron differentiation + 4
                      positive regulation of dopaminergic neuron differentiation + 3
                      regulation of dopaminergic neuron differentiation + 11
paths to the root