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ONTOLOGY REPORT - ANNOTATIONS


Term:dopaminergic neuron differentiation
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Accession:GO:0071542 term browser browse the term
Definition:The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.



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dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdnf cerebral dopamine neurotrophic factor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:74,714,564...74,728,639
Ensembl chr17:74,713,564...74,728,639
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 involved_in ISO (MGI:5700491|PMID:22535492) RGD PMID:22535492 MGI:5700491 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Dmrta2 DMRT-like family A2 acts_upstream_of_or_within ISO (MGI:5013657|PMID:21576465) RGD PMID:21576465 MGI:5013657 NCBI chr 5:124,805,883...124,811,694
Ensembl chr 5:124,805,883...124,811,630
JBrowse link
G Fgf8 fibroblast growth factor 8 involved_in ISO (PMID:15193767) RGD PMID:15193767 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Foxa2 forkhead box A2 involved_in
acts_upstream_of_or_within
IEA
ISO
ISS
GO_REF:0000107
MGI:1857725 (MGI:3772421|PMID:18076286)
GO_REF:0000024
UniProtKB:P32243|UniProtKB:Q9JKU8 (PMID:19951692)
Ensembl
RGD
ParkinsonsUK-UCL
PMID:18076286 PMID:19951692 GO_REF:0000024 GO_REF:0000107 MGI:3772421 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:103178|MGI:2386679 (MGI:3695975|PMID:17215402)
Ensembl
RGD
PMID:17215402 GO_REF:0000107 MGI:3695975 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP RGD PMID:17443768 RGD:6480676 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G L1cam L1 cell adhesion molecule IEP RGD PMID:1350253 RGD:11570519 NCBI chr  X:151,597,270...151,623,776
Ensembl chr  X:151,597,277...151,623,857
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha acts_upstream_of_or_within ISO MGI:1888413 (MGI:5285997|PMID:21752929), (MGI:5550348|PMID:24066094) RGD PMID:21752929 PMID:24066094 MGI:5285997 MGI:5550348 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253
JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta involved_in
acts_upstream_of_or_within
ISO UniProtKB:Q9JKU8 (MGI:5705221|PMID:19951692)
MGI:2158463 (MGI:5285997|PMID:21752929)
RGD PMID:19951692 PMID:21752929 MGI:5285997 MGI:5705221 NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:16,862,195...16,940,899
JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2156191 (MGI:4413371|PMID:19795519) RGD PMID:19795519 MGI:4413371 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 involved_in IEA
ISO
IBA
ISS
GO_REF:0000107
(MGI:3830409|PMID:19144721)
PMID:21873635
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:19144721 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:3830409, RGD:13792537 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Otx2 orthodenticle homeobox 2 involved_in ISO
IEA
UniProtKB:Q9JKU8|UniProtKB:Q9Y261 (PMID:19951692)
GO_REF:0000107
RGD
Ensembl
PMID:19951692 GO_REF:0000107 NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416
JBrowse link
G Phox2b paired-like homeobox 2b involved_in ISO (MGI:1337891|PMID:10360575) RGD PMID:10360575 MGI:1337891 NCBI chr14:41,066,012...41,069,202
Ensembl chr14:41,066,264...41,068,978
JBrowse link
G Pitx3 paired-like homeodomain 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:3582099|PMID:15950611), (MGI:3830409|PMID:19144721)
UniProt
RGD
PMID:15950611 PMID:19144721 GO_REF:0000024 MGI:3582099 MGI:3830409 NCBI chr 1:245,001,106...245,013,881
Ensembl chr 1:245,001,164...245,013,892
JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO MGI:98958 (MGI:3829860|PMID:18953410) RGD PMID:18953410 MGI:3829860 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rspo2 R-spondin 2 acts_upstream_of_or_within ISO MGI:3762378 (MGI:5550348|PMID:24066094) RGD PMID:24066094 MGI:5550348 NCBI chr 7:74,096,378...74,239,398
Ensembl chr 7:74,103,090...74,238,933
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5700491|PMID:22535492)
Ensembl
RGD
PMID:22535492 GO_REF:0000107 MGI:5700491 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Tshr thyroid stimulating hormone receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856914 (MGI:3652455|PMID:10575115)
Ensembl
RGD
PMID:10575115 GO_REF:0000107 MGI:3652455 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
JBrowse link
G Tshr-ps1 thyroid stimulating hormone receptor, pseudogene 1 acts_upstream_of_or_within ISO MGI:1856914 (MGI:3652455|PMID:10575115) RGD PMID:10575115 MGI:3652455 NCBI chr 4:92,142,656...92,143,138 JBrowse link
G Vegfa vascular endothelial growth factor A acts_upstream_of_or_within ISO MGI:106918 (MGI:3695975|PMID:17215402) RGD PMID:17215402 MGI:3695975 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfd vascular endothelial growth factor D involved_in IEA
ISO
GO_REF:0000107
(MGI:5700491|PMID:22535492)
Ensembl
RGD
PMID:22535492 GO_REF:0000107 MGI:5700491 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295
JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (MGI:5469218|PMID:23324743) RGD PMID:23324743 MGI:5469218 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
G Wnt5a Wnt family member 5A acts_upstream_of_or_within
involved_in
ISO MGI:1857617|MGI:97845 (MGI:3829860|PMID:18953410)
UniProtKB:P04426 (MGI:5469218|PMID:23324743)
RGD PMID:18953410 PMID:23324743 MGI:3829860 MGI:5469218 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt1 Wnt family member 1 involved_in ISO (MGI:5705221|PMID:19951692) RGD PMID:19951692 MGI:5705221 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
G Wnt2 Wnt family member 2 involved_in ISO (PMID:20018874) RGD PMID:20018874 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402
JBrowse link
G Wnt3 Wnt family member 3 involved_in IEA
ISO
GO_REF:0000107
(PMID:25640183)
Ensembl
RGD
PMID:25640183 GO_REF:0000107 NCBI chr10:88,680,248...88,724,170
Ensembl chr10:88,680,248...88,724,099
JBrowse link
midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:3836885|PMID:19122665)
Ensembl
RGD
PMID:19122665 GO_REF:0000107 MGI:3836885 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha involved_in ISO (MGI:5705221|PMID:19951692) RGD PMID:19951692 MGI:5705221 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253
JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (MGI:3829860|PMID:18953410), (MGI:5466648|PMID:23109420) RGD PMID:18953410 PMID:23109420 MGI:3829860 MGI:5466648 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Ryk receptor-like tyrosine kinase involved_in ISO (MGI:5707582|PMID:23517308) RGD PMID:23517308 MGI:5707582 NCBI chr 8:103,419,348...103,492,083
Ensembl chr 8:103,419,275...103,491,698
JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (MGI:5469218|PMID:23324743) RGD PMID:23324743 MGI:5469218 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
G Wnt2 Wnt family member 2 involved_in ISO (PMID:20018874) RGD PMID:20018874 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402
JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO UniProtKB:P04426 (MGI:2679774|PMID:14557550), (MGI:3829860|PMID:18953410), (MGI:5469218|PMID:23324743), (MGI:5700308|PMID:15748172) RGD PMID:14557550 PMID:15748172 PMID:18953410 PMID:23324743 MGI:2679774 MGI:3829860 MGI:5469218 MGI:5700308 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Wnt9b Wnt family member 9B involved_in ISO (PMID:25640183) RGD PMID:25640183 NCBI chr10:88,635,330...88,657,035
Ensembl chr10:88,635,331...88,657,035
JBrowse link
negative regulation of dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:15522889 RGD:10045566 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA
ISO
GO_REF:0000107
(MGI:3836885|PMID:19122665)
Ensembl
RGD
PMID:19122665 GO_REF:0000107 MGI:3836885 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Wnt3a Wnt family member 3A involved_in ISO (MGI:2679774|PMID:14557550) RGD PMID:14557550 MGI:2679774 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt9b Wnt family member 9B involved_in ISO (PMID:25640183) RGD PMID:25640183 NCBI chr10:88,635,330...88,657,035
Ensembl chr10:88,635,331...88,657,035
JBrowse link
positive regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (MGI:4948425|PMID:21347250) RGD PMID:21347250 MGI:4948425 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csnk1e casein kinase 1, epsilon involved_in NAS PMID:17244647 ParkinsonsUK-UCL PMID:17244647 RGD:10448953 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
JBrowse link
regulation of dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tiam1 TIAM Rac1 associated GEF 1 involved_in ISO (MGI:5466648|PMID:23109420) RGD PMID:23109420 MGI:5466648 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901
JBrowse link
regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sfrp1 secreted frizzled-related protein 1 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P97299 (MGI:5448935|PMID:22290867)
Ensembl
RGD
PMID:22290867 GO_REF:0000107 MGI:5448935 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 involved_in ISO UniProtKB:Q8C4U3 (MGI:5448935|PMID:22290867) RGD PMID:22290867 MGI:5448935 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063
JBrowse link
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in IEA
ISO
GO_REF:0000107
(MGI:5707582|PMID:23517308)
Ensembl
RGD
PMID:23517308 GO_REF:0000107 MGI:5707582 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19541
    cellular process 18407
      cellular developmental process 4576
        cell differentiation 4481
          neuron differentiation 1634
            dopaminergic neuron differentiation 37
              midbrain dopaminergic neuron differentiation + 13
              negative regulation of dopaminergic neuron differentiation + 3
              positive regulation of dopaminergic neuron differentiation + 2
              regulation of dopaminergic neuron differentiation + 8
Path 2
Term Annotations click to browse term
  biological_process 19541
    developmental process 6920
      anatomical structure development 6337
        multicellular organism development 5765
          system development 5408
            nervous system development 2746
              neurogenesis 1968
                generation of neurons 1808
                  neuron differentiation 1634
                    dopaminergic neuron differentiation 37
                      midbrain dopaminergic neuron differentiation + 13
                      negative regulation of dopaminergic neuron differentiation + 3
                      positive regulation of dopaminergic neuron differentiation + 2
                      regulation of dopaminergic neuron differentiation + 8
paths to the root