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ONTOLOGY REPORT - ANNOTATIONS

Term:dopaminergic neuron differentiation
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Accession:GO:0071542 term browser browse the term
Definition:The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.


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dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdnf cerebral dopamine neurotrophic factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:74,714,564...74,728,639
Ensembl chr17:74,713,564...74,728,639 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 involved_in ISO (PMID:22535492) RGD PMID:22535492 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Dmrta2 DMRT-like family A2 acts_upstream_of_or_within ISO (PMID:21576465) RGD PMID:21576465 NCBI chr 5:124,805,883...124,811,694
Ensembl chr 5:124,805,883...124,811,630 		JBrowse link
G En1 engrailed homeobox 1 acts_upstream_of_or_within ISO MGI:95390 (PMID:15175251), (PMID:15340832) RGD PMID:15175251 PMID:15340832 NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943 		JBrowse link
G En2 engrailed homeobox 2 acts_upstream_of_or_within ISO MGI:95389 (PMID:15175251), (PMID:15340832) RGD PMID:15175251 PMID:15340832 NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943 		JBrowse link
G Fgf8 fibroblast growth factor 8 involved_in ISO (PMID:15193767) RGD PMID:15193767 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 acts_upstream_of_or_within ISO (PMID:38693257) RGD PMID:38693257 NCBI chr 4:67,274,104...67,282,140
Ensembl chr 4:67,274,104...67,282,140 		JBrowse link
G Foxa1 forkhead box A1 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:1347476|MGI:2653543 (PMID:17596284)		 Ensembl
RGD		 PMID:17596284 GO_REF:0000107 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Foxa2 forkhead box A2 involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 GO_REF:0000107
MGI:1857725 (PMID:18076286)
MGI:1347472|MGI:2177337 (PMID:17596284)
GO_REF:0000024
UniProtKB:P32243|UniProtKB:Q9JKU8 (PMID:19951692)		 Ensembl
RGD
ParkinsonsUK-UCL		 PMID:17596284 PMID:18076286 PMID:19951692 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:103178|MGI:2386679 (PMID:17215402)		 Ensembl
RGD		 PMID:17215402 GO_REF:0000107 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857299 (PMID:11297820)		 Ensembl
RGD		 PMID:11297820 GO_REF:0000107 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP RGD PMID:17443768 RGD:6480676 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of ISO MGI:3830733 (PMID:19109490) RGD PMID:19109490 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G L1cam L1 cell adhesion molecule IEP RGD PMID:1350253 RGD:11570519 NCBI chr  X:151,597,270...151,623,776
Ensembl chr  X:151,597,277...151,623,857 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha acts_upstream_of_or_within ISO MGI:1888413 (PMID:21752929), (PMID:24066094) RGD PMID:21752929 PMID:24066094 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253 		JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta acts_upstream_of_or_within
involved_in		 ISO MGI:2158463 (PMID:21752929)
UniProtKB:Q9JKU8 (PMID:19951692)		 RGD PMID:19951692 PMID:21752929 NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:16,862,195...16,940,899 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2156191 (PMID:19795519) RGD PMID:19795519 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438 		JBrowse link
G Neurog2 neurogenin 2 acts_upstream_of_or_within ISO MGI:2673381 (PMID:16396906) RGD PMID:16396906 NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:19144721)
MGI:2429971|MGI:3043985 (PMID:11113533), (PMID:14622207), (PMID:9520484)
GO_REF:0000033
GO_REF:0000107		 UniProt
RGD
GO_Central
Ensembl		 PMID:9520484 PMID:11113533 PMID:14622207 PMID:19144721 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Otp orthopedia homeobox acts_upstream_of_or_within ISO MGI:2180541 (PMID:17481897) RGD PMID:17481897 NCBI chr 2:26,108,158...26,116,359
Ensembl chr 2:26,108,163...26,116,359 		JBrowse link
G Otx2 orthodenticle homeobox 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 UniProtKB:Q9JKU8|UniProtKB:Q9Y261 (PMID:19951692)
MGI:2176222|MGI:2661065 (PMID:15888661)
GO_REF:0000107		 RGD
Ensembl		 PMID:15888661 PMID:19951692 GO_REF:0000107 NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416 		JBrowse link
G Phox2b paired-like homeobox 2b involved_in ISO (PMID:10360575) RGD PMID:10360575 NCBI chr14:41,066,012...41,069,202
Ensembl chr14:41,066,264...41,068,978 		JBrowse link
G Pitx3 paired-like homeodomain 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15950611), (PMID:19144721)		 UniProt
RGD		 PMID:15950611 PMID:19144721 GO_REF:0000024 NCBI chr 1:245,001,106...245,013,881
Ensembl chr 1:245,001,164...245,013,892 		JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO MGI:98958 (PMID:18953410) RGD PMID:18953410 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rspo2 R-spondin 2 acts_upstream_of_or_within ISO MGI:3762378 (PMID:24066094) RGD PMID:24066094 NCBI chr 7:74,096,378...74,239,398
Ensembl chr 7:74,103,090...74,238,933 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22535492)		 Ensembl
RGD		 PMID:22535492 GO_REF:0000107 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Smo smoothened, frizzled class receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2176256|MGI:2446434 (PMID:16571630)		 Ensembl
RGD		 PMID:16571630 GO_REF:0000107 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Tshr thyroid stimulating hormone receptor acts_upstream_of_or_within ISO MGI:1856914 (PMID:10575115) RGD PMID:10575115 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538 		JBrowse link
G Vegfa vascular endothelial growth factor A acts_upstream_of_or_within ISO MGI:106918 (PMID:17215402) RGD PMID:17215402 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfd vascular endothelial growth factor D involved_in IEA
ISO		 GO_REF:0000107
(PMID:22535492)		 Ensembl
RGD		 PMID:22535492 GO_REF:0000107 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295 		JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (PMID:23324743) RGD PMID:23324743 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
G Wnt5a Wnt family member 5A acts_upstream_of_or_within
involved_in		 ISO MGI:1857617|MGI:97845 (PMID:18953410)
UniProtKB:P04426 (PMID:23324743)		 RGD PMID:18953410 PMID:23324743 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csnk1d casein kinase 1, delta involved_in ISO UniProtKB:P22725 (PMID:17244647) RGD PMID:17244647 NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19122665)		 Ensembl
RGD		 PMID:19122665 GO_REF:0000107 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha involved_in ISO (PMID:19951692) RGD PMID:19951692 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253 		JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (PMID:18953410), (PMID:23109420) RGD PMID:18953410 PMID:23109420 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Ryk receptor-like tyrosine kinase involved_in ISO (PMID:23517308) RGD PMID:23517308 NCBI chr 8:103,419,338...103,492,083
Ensembl chr 8:103,419,275...103,491,698 		JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (PMID:19951692), (PMID:23324743) RGD PMID:19951692 PMID:23324743 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
G Wnt2 Wnt family member 2 involved_in ISO (PMID:20018874) RGD PMID:20018874 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402 		JBrowse link
G Wnt3 Wnt family member 3 involved_in ISO (PMID:25640183) RGD PMID:25640183 NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099 		JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P04426 (PMID:14557550), (PMID:15748172), (PMID:18953410), (PMID:23324743), (PMID:23517308)		 Ensembl
RGD		 PMID:14557550 PMID:15748172 PMID:18953410 PMID:23324743 PMID:23517308 GO_REF:0000107 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Wnt9b Wnt family member 9B involved_in ISO (PMID:25640183) RGD PMID:25640183 NCBI chr10:88,635,330...88,657,035
Ensembl chr10:88,635,331...88,657,035 		JBrowse link
negative regulation of dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:15522889 RGD:10045566 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO MGI:3830733 (PMID:19109490) RGD PMID:19109490 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA
ISO		 GO_REF:0000107
(PMID:19122665)		 Ensembl
RGD		 PMID:19122665 GO_REF:0000107 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Wnt3a Wnt family member 3A involved_in ISO (PMID:14557550) RGD PMID:14557550 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
positive regulation of dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxa1 forkhead box A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1347476|MGI:2653543 (PMID:17596284)		 Ensembl
RGD		 PMID:17596284 GO_REF:0000107 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Foxa2 forkhead box A2 acts_upstream_of_or_within ISO MGI:1347472|MGI:2177337 (PMID:17596284) RGD PMID:17596284 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326 		JBrowse link
positive regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:21347250) RGD PMID:21347250 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
regulation of dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ferd3l Fer3-like bHLH transcription factor acts_upstream_of_or_within ISO MGI:4460989 (PMID:20460368) RGD PMID:20460368 NCBI chr 6:50,645,379...50,646,268
Ensembl chr 6:50,645,379...50,646,268 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 involved_in ISO (PMID:23109420) RGD PMID:23109420 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sfrp1 secreted frizzled-related protein 1 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P97299 (PMID:22290867)		 Ensembl
RGD		 PMID:22290867 GO_REF:0000107 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 involved_in ISO UniProtKB:Q8C4U3 (PMID:22290867) RGD PMID:22290867 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20075
    cellular process 19154
      cellular developmental process 4781
        cell differentiation 4780
          neuron differentiation 1722
            dopaminergic neuron differentiation 46
              midbrain dopaminergic neuron differentiation + 13
              negative regulation of dopaminergic neuron differentiation + 4
              positive regulation of dopaminergic neuron differentiation + 3
              regulation of dopaminergic neuron differentiation + 11
Path 2
Term Annotations click to browse term
  biological_process 20075
    developmental process 7069
      anatomical structure development 6572
        multicellular organism development 5298
          system development 4583
            nervous system development 2847
              neurogenesis 2110
                generation of neurons 1807
                  neuron differentiation 1722
                    dopaminergic neuron differentiation 46
                      midbrain dopaminergic neuron differentiation + 13
                      negative regulation of dopaminergic neuron differentiation + 4
                      positive regulation of dopaminergic neuron differentiation + 3
                      regulation of dopaminergic neuron differentiation + 11
paths to the root