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ONTOLOGY REPORT - ANNOTATIONS


Term:dopaminergic neuron differentiation
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Accession:GO:0071542 term browser browse the term
Definition:The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.


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dopaminergic neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdnf cerebral dopamine neurotrophic factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:78,721,230...78,735,324
Ensembl chr17:78,719,111...78,735,324
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO (MGI:MGI:5700491|PMID:22535492) RGD PMID:22535492 MGI:MGI:5700491 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Dmrta2 DMRT-like family A2 ISO (MGI:MGI:5013657|PMID:21576465) RGD PMID:21576465 MGI:MGI:5013657 NCBI chr 5:129,754,295...129,760,045
Ensembl chr 5:129,756,149...129,758,986
JBrowse link
G Fgf8 fibroblast growth factor 8 ISO (PMID:15193767) RGD PMID:15193767 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Foxa2 forkhead box A2 ISO
IEA
ISS
MGI:MGI:1857725 (MGI:MGI:3772421|PMID:18076286)
GO_REF:0000107
GO_REF:0000024
UniProtKB:P32243|UniProtKB:Q9JKU8 (PMID:19951692)
RGD
Ensembl
ParkinsonsUK-UCL
PMID:18076286, PMID:19951692 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3772421 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO
IEA
MGI:MGI:103178|MGI:MGI:2386679 (MGI:MGI:3695975|PMID:17215402)
GO_REF:0000107
RGD
Ensembl
PMID:17215402 GO_REF:0000107, MGI:MGI:3695975 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP RGD PMID:17443768 RGD:6480676 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G L1cam L1 cell adhesion molecule IEP RGD PMID:1350253 RGD:11570519 NCBI chr  X:156,901,244...156,928,064
Ensembl chr  X:156,909,913...156,928,057
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha ISO MGI:MGI:1888413 (MGI:MGI:5285997|PMID:21752929), (MGI:MGI:5550348|PMID:24066094) RGD PMID:21752929, PMID:24066094 MGI:MGI:5285997, MGI:MGI:5550348 NCBI chr13:85,916,753...86,061,534
Ensembl chr13:85,918,252...86,061,176
JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta ISO MGI:MGI:2158463|UniProtKB:Q9JKU8 (MGI:MGI:5285997|PMID:21752929), (MGI:MGI:5705221|PMID:19951692) RGD PMID:19951692, PMID:21752929 MGI:MGI:5285997, MGI:MGI:5705221 NCBI chr 3:12,608,748...12,686,937
Ensembl chr 3:12,609,574...12,686,869
JBrowse link
G Lrp6 LDL receptor related protein 6 ISO MGI:MGI:2156191 (MGI:MGI:4413371|PMID:19795519) RGD PMID:19795519 MGI:MGI:4413371 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:115,623,175...115,626,408
Ensembl chr 8:115,623,178...115,626,380
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(MGI:MGI:3830409|PMID:19144721)
Ensembl
UniProt
RGD
PMID:19144721, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3830409, RGD:13792537 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Otx2 orthodenticle homeobox 2 ISO UniProtKB:Q9JKU8|UniProtKB:Q9Y261 (PMID:19951692) RGD PMID:19951692 NCBI chr15:25,500,037...25,511,619
Ensembl chr15:25,502,019...25,505,691
JBrowse link
G Phox2b paired-like homeobox 2b ISO (MGI:MGI:1337891|PMID:10360575) RGD PMID:10360575 MGI:MGI:1337891 NCBI chr14:42,711,169...42,718,707
Ensembl chr14:42,714,315...42,717,010
JBrowse link
G Pitx3 paired-like homeodomain 3 ISS
ISO
GO_REF:0000024
(MGI:MGI:3582099|PMID:15950611), (MGI:MGI:3830409|PMID:19144721)
UniProt
RGD
PMID:15950611, PMID:19144721 GO_REF:0000024, MGI:MGI:3582099, MGI:MGI:3830409 NCBI chr 1:265,886,766...265,899,947
Ensembl chr 1:265,887,230...265,899,958
JBrowse link
G Rac1 Rac family small GTPase 1 ISO MGI:MGI:98958 (MGI:MGI:3829860|PMID:18953410) RGD PMID:18953410 MGI:MGI:3829860 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rspo2 R-spondin 2 ISO MGI:MGI:3762378 (MGI:MGI:5550348|PMID:24066094) RGD PMID:24066094 MGI:MGI:5550348 NCBI chr 7:81,919,911...82,059,659
Ensembl chr 7:81,924,050...82,059,789
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 ISO
IEA
(MGI:MGI:5700491|PMID:22535492)
GO_REF:0000107
RGD
Ensembl
PMID:22535492 GO_REF:0000107, MGI:MGI:5700491 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Tshr thyroid stimulating hormone receptor IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 6:115,170,290...115,306,871
Ensembl chr 6:115,170,865...115,306,871
JBrowse link
G Tshr-ps1 thyroid stimulating hormone receptor, pseudogene 1 ISO MGI:MGI:1856914 (MGI:MGI:3652455|PMID:10575115) RGD PMID:10575115 MGI:MGI:3652455 NCBI chr 4:93,447,412...93,448,194 JBrowse link
G Vegfa vascular endothelial growth factor A ISO MGI:MGI:106918 (MGI:MGI:3695975|PMID:17215402) RGD PMID:17215402 MGI:MGI:3695975 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfd vascular endothelial growth factor D ISO
IEA
(MGI:MGI:5700491|PMID:22535492)
GO_REF:0000107
RGD
Ensembl
PMID:22535492 GO_REF:0000107, MGI:MGI:5700491 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
G Wnt1 Wnt family member 1 ISO (MGI:MGI:5469218|PMID:23324743) RGD PMID:23324743 MGI:MGI:5469218 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link
G Wnt5a Wnt family member 5A ISO MGI:MGI:1857617|MGI:MGI:97845|UniProtKB:P04426 (MGI:MGI:3829860|PMID:18953410), (MGI:MGI:5469218|PMID:23324743) RGD PMID:18953410, PMID:23324743 MGI:MGI:3829860, MGI:MGI:5469218 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt1 Wnt family member 1 ISO (MGI:MGI:5705221|PMID:19951692) RGD PMID:19951692 MGI:MGI:5705221 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link
G Wnt2 Wnt family member 2 ISO (PMID:20018874) RGD PMID:20018874 NCBI chr 4:45,286,845...45,332,899
Ensembl chr 4:45,292,437...45,332,420
JBrowse link
G Wnt3 Wnt family member 3 ISO
IEA
(PMID:25640183)
GO_REF:0000107
RGD
Ensembl
PMID:25640183 GO_REF:0000107 NCBI chr10:91,830,709...91,874,907
Ensembl chr10:91,830,654...91,874,793
JBrowse link
midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 ISO
IEA
(MGI:MGI:3836885|PMID:19122665)
GO_REF:0000107
RGD
Ensembl
PMID:19122665 GO_REF:0000107, MGI:MGI:3836885 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha ISO (MGI:MGI:5705221|PMID:19951692) RGD PMID:19951692 MGI:MGI:5705221 NCBI chr13:85,916,753...86,061,534
Ensembl chr13:85,918,252...86,061,176
JBrowse link
G Rac1 Rac family small GTPase 1 ISO (MGI:MGI:3829860|PMID:18953410), (MGI:MGI:5466648|PMID:23109420) RGD PMID:18953410, PMID:23109420 MGI:MGI:3829860, MGI:MGI:5466648 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Ryk receptor-like tyrosine kinase ISO (MGI:MGI:5707582|PMID:23517308) RGD PMID:23517308 MGI:MGI:5707582 NCBI chr 8:111,326,339...111,398,640
Ensembl chr 8:111,326,433...111,397,867
JBrowse link
G Wnt1 Wnt family member 1 ISO (MGI:MGI:5469218|PMID:23324743) RGD PMID:23324743 MGI:MGI:5469218 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link
G Wnt2 Wnt family member 2 ISO (PMID:20018874) RGD PMID:20018874 NCBI chr 4:45,286,845...45,332,899
Ensembl chr 4:45,292,437...45,332,420
JBrowse link
G Wnt5a Wnt family member 5A ISO UniProtKB:P04426 (MGI:MGI:2679774|PMID:14557550), (MGI:MGI:3829860|PMID:18953410), (MGI:MGI:5469218|PMID:23324743), (MGI:MGI:5700308|PMID:15748172) RGD PMID:14557550, PMID:15748172, PMID:18953410, PMID:23324743 MGI:MGI:2679774, MGI:MGI:3829860, MGI:MGI:5469218, MGI:MGI:5700308 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Wnt9b Wnt family member 9B ISO (PMID:25640183) RGD PMID:25640183 NCBI chr10:91,785,892...91,808,061
Ensembl chr10:91,785,893...91,807,937
JBrowse link
negative regulation of dopaminergic neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:15522889 RGD:10045566 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Shh sonic hedgehog signaling molecule ISO
IEA
(MGI:MGI:3836885|PMID:19122665)
GO_REF:0000107
RGD
Ensembl
PMID:19122665 GO_REF:0000107, MGI:MGI:3836885 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Wnt3a Wnt family member 3A ISO (MGI:MGI:2679774|PMID:14557550) RGD PMID:14557550 MGI:MGI:2679774 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt9b Wnt family member 9B ISO (PMID:25640183) RGD PMID:25640183 NCBI chr10:91,785,892...91,808,061
Ensembl chr10:91,785,893...91,807,937
JBrowse link
positive regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (MGI:MGI:4948425|PMID:21347250) RGD PMID:21347250 MGI:MGI:4948425 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csnk1e casein kinase 1, epsilon NAS PMID:17244647 ParkinsonsUK-UCL PMID:17244647 RGD:10448953 NCBI chr 7:120,651,976...120,675,559
Ensembl chr 7:120,651,881...120,672,359
JBrowse link
regulation of dopaminergic neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tiam1 TIAM Rac1 associated GEF 1 ISO (MGI:MGI:5466648|PMID:23109420) RGD PMID:23109420 MGI:MGI:5466648 NCBI chr11:29,931,083...30,061,173
Ensembl chr11:29,933,163...30,051,103
JBrowse link
regulation of midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sfrp1 secreted frizzled-related protein 1 ISO
IEA
UniProtKB:P97299 (MGI:MGI:5448935|PMID:22290867)
GO_REF:0000107
RGD
Ensembl
PMID:22290867 GO_REF:0000107, MGI:MGI:5448935 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO UniProtKB:Q8C4U3 (MGI:MGI:5448935|PMID:22290867) RGD PMID:22290867 MGI:MGI:5448935 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A IEA
ISO
GO_REF:0000107
(MGI:MGI:5707582|PMID:23517308)
Ensembl
RGD
PMID:23517308 GO_REF:0000107, MGI:MGI:5707582 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cellular developmental process 4459
        cell differentiation 4364
          neuron differentiation 1617
            dopaminergic neuron differentiation 37
              midbrain dopaminergic neuron differentiation + 13
              negative regulation of dopaminergic neuron differentiation + 3
              positive regulation of dopaminergic neuron differentiation + 2
              regulation of dopaminergic neuron differentiation + 8
Path 2
Term Annotations click to browse term
  biological_process 20028
    developmental process 6827
      anatomical structure development 6269
        multicellular organism development 5744
          system development 5280
            nervous system development 2722
              neurogenesis 1938
                generation of neurons 1781
                  neuron differentiation 1617
                    dopaminergic neuron differentiation 37
                      midbrain dopaminergic neuron differentiation + 13
                      negative regulation of dopaminergic neuron differentiation + 3
                      positive regulation of dopaminergic neuron differentiation + 2
                      regulation of dopaminergic neuron differentiation + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.