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ONTOLOGY REPORT - ANNOTATIONS

Term:semaphorin-plexin signaling pathway
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Accession:GO:0071526 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
Synonyms:exact_synonym: semaphorin-plexin signalling pathway


show annotations for term's descendants           Sort by:
semaphorin-plexin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgdia Rho GDP dissociation inhibitor alpha involved_in ISS
ISO 		GO_REF:0000024
(PMID:20696765) 		UniProt
RGD		 PMID:20696765 GO_REF:0000024 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Crmp1 collapsin response mediator protein 1 involved_in ISO
IEA 		UniProtKB:O08665|UniProtKB:Q8BTM8 (PMID:25358863)
GO_REF:0000107 		RGD
Ensembl		 PMID:25358863 GO_REF:0000107 NCBI chr14:73,509,933...73,556,192
Ensembl chr14:73,509,933...73,556,177 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:22019888) 		Ensembl
RGD		 PMID:22019888 GO_REF:0000107 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Farp2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 involved_in ISO
IEA 		(PMID:20702777)
GO_REF:0000107 		RGD
Ensembl		 PMID:20702777 GO_REF:0000107 NCBI chr 9:94,053,650...94,161,982
Ensembl chr 9:94,053,726...94,162,212 		JBrowse link
G Flna filamin A involved_in ISO
IEA 		UniProtKB:O08665|UniProtKB:Q8BTM8 (PMID:25358863)
GO_REF:0000107
UniProtKB:O08665 (PMID:25358863) 		RGD
Ensembl		 PMID:25358863 GO_REF:0000107 NCBI chr  X:157,159,051...157,185,559
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Kdr kinase insert domain receptor involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:O15041 (PMID:25985275) 		Ensembl
RGD		 PMID:25985275 GO_REF:0000107 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:15218527)
GO_REF:0000107
GO_REF:0000002 		UniProt
RGD
Ensembl
InterPro		 PMID:15218527 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Nrp1 neuropilin 1 involved_in
acts_upstream_of_or_within 		IEA
ISO 		GO_REF:0000108
GO_REF:0000107
(PMID:18804103), (PMID:22790009), (PMID:26053665)
MGI:107558|MGI:2154244|MGI:2179061 (PMID:12591607), (PMID:15239958) 		GOC
Ensembl
RGD		 PMID:12591607 PMID:15239958 PMID:18804103 PMID:22790009 PMID:26053665 GO_REF:0000107 GO_REF:0000108 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 involved_in IEA
ISO 		GO_REF:0000108
(PMID:22790009)
GO_REF:0000107 		GOC
RGD
Ensembl		 PMID:22790009 GO_REF:0000107 GO_REF:0000108 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Plxna1 plexin A1 involved_in ISO
IEA
IBA 		(PMID:16715077)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033 		RGD
Ensembl
InterPro
GO_Central		 PMID:16715077 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:121,737,934...121,782,901
Ensembl chr 4:121,737,945...122,024,196 		JBrowse link
G Plxna2 plexin A2 involved_in ISO
IEA
IBA 		(PMID:20877282)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033 		RGD
InterPro
Ensembl
GO_Central		 PMID:20877282 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr13:106,163,103...106,358,979
Ensembl chr13:106,163,103...106,358,979 		JBrowse link
G Plxna3 plexin A3 involved_in ISO
IEA
IBA 		(PMID:18804103)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033 		RGD
Ensembl
InterPro
GO_Central		 PMID:18804103 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:152,115,699...152,131,608
Ensembl chr  X:152,115,819...152,131,603 		JBrowse link
G Plxna4 plexin A4 acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		MGI:106206|MGI:107558|MGI:3578655 (PMID:12591607), (PMID:15814794)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
(PMID:18804103) 		RGD
InterPro
Ensembl
GO_Central		 PMID:12591607 PMID:15814794 PMID:18804103 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:60,720,246...61,162,206
Ensembl chr 4:60,720,255...61,162,206 		JBrowse link
G Plxnb1 plexin B1 involved_in ISO
IEA
IBA 		(PMID:15218527), (PMID:19843518)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:19788569), (PMID:22019888) 		RGD
Ensembl
InterPro
GO_Central		 PMID:15218527 PMID:19788569 PMID:19843518 PMID:22019888 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:109,743,470...109,769,153
Ensembl chr 8:109,744,697...109,769,027 		JBrowse link
G Plxnb2 plexin B2 involved_in ISO
IEA
IBA 		(PMID:17554007)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033 		RGD
InterPro
Ensembl
GO_Central		 PMID:17554007 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330 		JBrowse link
G Plxnb3 plexin B3 involved_in ISO
IEA
IBA
IMP 		(PMID:15218527)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
PMID:20696765 		RGD
Ensembl
InterPro
GO_Central		 PMID:15218527 PMID:20696765 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:8554409 NCBI chr  X:151,493,832...151,508,688
Ensembl chr  X:151,494,207...151,508,674 		JBrowse link
G Plxnc1 plexin C1 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:29,390,038...29,543,985
Ensembl chr 7:29,390,048...29,543,779 		JBrowse link
G Plxnd1 plexin D1 acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		MGI:106206|MGI:1100492 (PMID:15239958)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
UniProtKB:O15041 (PMID:17318185), (PMID:25985275), (PMID:26053665) 		RGD
Ensembl
InterPro
GO_Central		 PMID:15239958 PMID:17318185 PMID:25985275 PMID:26053665 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244 		JBrowse link
G Rac1 Rac family small GTPase 1 involved_in IMP PMID:20696765 UniProt PMID:20696765 RGD:8554409 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rhoa ras homolog family member A involved_in ISO (PMID:22019888) RGD PMID:22019888 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Sema3a semaphorin 3A acts_upstream_of_or_within
involved_in 		ISO
IBA 		MGI:106206|MGI:2179061 (PMID:12591607)
GO_REF:0000033
(PMID:18804103), (PMID:22790009) 		RGD
GO_Central		 PMID:12591607 PMID:18804103 PMID:22790009 GO_REF:0000033 NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432 		JBrowse link
G Sema3b semaphorin 3B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919 		JBrowse link
G Sema3c semaphorin 3C involved_in ISO
IEA
IBA 		(PMID:26053665)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:26053665 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:18,538,452...18,702,453
Ensembl chr 4:17,583,212...17,746,534 		JBrowse link
G Sema3d semaphorin 3D involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:22,316,769...22,505,930
Ensembl chr 4:22,316,779...22,505,930 		JBrowse link
G Sema3e semaphorin 3E involved_in ISO
IEA
IBA 		UniProtKB:Q3UH93 (PMID:25985275)
GO_REF:0000107
GO_REF:0000033
(PMID:15550623) 		RGD
Ensembl
GO_Central		 PMID:15550623 PMID:25985275 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229 		JBrowse link
G Sema3f semaphorin 3F involved_in ISO
IEA
IBA 		(PMID:18804103), (PMID:22790009)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:18804103 PMID:22790009 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:117,236,269...117,265,206
Ensembl chr 8:108,357,629...108,387,083 		JBrowse link
G Sema3g semaphorin 3G involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:6,413,589...6,425,221
Ensembl chr16:6,413,589...6,425,221 		JBrowse link
G Sema4a semaphorin 4A involved_in ISO
IEA
IBA 		(PMID:17318185), (PMID:20043131)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:17318185 PMID:20043131 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:176,194,248...176,215,752
Ensembl chr 2:173,896,439...173,914,442 		JBrowse link
G Sema4b semaphorin 4B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:134,136,646...134,177,777
Ensembl chr 1:134,149,536...134,177,775 		JBrowse link
G Sema4c semaphorin 4C involved_in ISO
IEA
IBA 		(PMID:21122816)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:21122816 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:38,791,668...38,802,171
Ensembl chr 9:38,791,670...38,802,128 		JBrowse link
G Sema4d semaphorin 4D involved_in ISO
IEA
IBA 		(PMID:15218527), (PMID:19788569), (PMID:20877282), (PMID:22019888)
GO_REF:0000107
GO_REF:0000033
(PMID:22019888) 		RGD
Ensembl
GO_Central		 PMID:15218527 PMID:19788569 PMID:20877282 PMID:22019888 GO_REF:0000033 GO_REF:0000107 NCBI chr17:13,430,324...13,537,146
Ensembl chr17:13,430,379...13,537,138 		JBrowse link
G Sema4f semaphorin 4F involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:115,411,411...115,437,721
Ensembl chr 4:115,411,417...115,437,721 		JBrowse link
G Sema4g semaphorin 4G involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:243,849,979...243,865,343
Ensembl chr 1:243,853,854...243,865,341 		JBrowse link
G Sema5a semaphorin 5A involved_in ISS
IBA
ISO 		GO_REF:0000024
GO_REF:0000033
(PMID:15218527) 		UniProt
GO_Central
RGD		 PMID:15218527 GO_REF:0000024 GO_REF:0000033 NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084 		JBrowse link
G Sema5b semaphorin 5B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:65,102,532...65,225,456
Ensembl chr11:65,102,031...65,225,311 		JBrowse link
G Sema6a semaphorin 6A involved_in ISO
IBA 		(PMID:20877282)
GO_REF:0000033 		RGD
GO_Central		 PMID:20877282 GO_REF:0000033 NCBI chr18:40,050,623...40,171,954
Ensembl chr18:40,050,624...40,171,954 		JBrowse link
G Sema6b semaphorin 6B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:1,038,103...1,055,063
Ensembl chr 9:950,939...961,521 		JBrowse link
G Sema6c semaphorin 6C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:182,733,635...182,750,066
Ensembl chr 2:182,737,474...182,746,856 		JBrowse link
G Sema6d semaphorin 6D involved_in ISO
IEA
IBA 		(PMID:16715077)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:16715077 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:111,883,415...111,941,100
Ensembl chr 3:111,883,872...111,941,094 		JBrowse link
G Sema7a semaphorin 7A (John Milton Hagen blood group) involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536 		JBrowse link
G Sh3bp1 SH3-domain binding protein 1 involved_in ISO
ISS 		(PMID:24841563)
GO_REF:0000024 		RGD
UniProt		 PMID:24841563 GO_REF:0000024 NCBI chr 7:112,338,087...112,350,659
Ensembl chr 7:110,457,710...110,470,201 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:16715077) RGD PMID:16715077 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISS
ISO 		GO_REF:0000024
(PMID:16715077) 		UniProt
RGD		 PMID:16715077 GO_REF:0000024 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
positive regulation of semaphorin-plexin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hand2 heart and neural crest derivatives expressed 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:19008477) 		Ensembl
RGD		 PMID:19008477 GO_REF:0000107 NCBI chr16:37,928,145...37,931,488
Ensembl chr16:32,917,823...32,919,891 		JBrowse link
regulation of semaphorin-plexin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdnf glial cell derived neurotrophic factor involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P13595 (PMID:22998873) 		Ensembl
RGD		 PMID:22998873 GO_REF:0000107 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Mir23a microRNA 23a acts_upstream_of_or_within ISO (PMID:21536891) RGD PMID:21536891 NCBI chr19:40,859,769...40,859,843
Ensembl chr19:23,954,997...23,955,071 		JBrowse link
G Mir23b microRNA 23b acts_upstream_of_or_within ISO (PMID:21536891) RGD PMID:21536891 NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763 		JBrowse link
G Mir27a microRNA 27a acts_upstream_of_or_within ISO (PMID:21536891) RGD PMID:21536891 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
G Mir27b microRNA 27b acts_upstream_of_or_within ISO (PMID:21536891) RGD PMID:21536891 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 involved_in ISO UniProtKB:P48540 (PMID:22998873) RGD PMID:22998873 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
semaphorin-plexin signaling pathway involved in axon guidance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ece1 endothelin converting enzyme 1 involved_in IEA
ISO 		GO_REF:0000107
MGI:1857637|MGI:2158947|MGI:2687362 (PMID:30735130) 		Ensembl
RGD		 PMID:30735130 GO_REF:0000107 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Edn1 endothelin 1 involved_in ISO
IEA 		MGI:1857637|MGI:2158947|MGI:2687362 (PMID:30735130)
GO_REF:0000107 		RGD
Ensembl		 PMID:30735130 GO_REF:0000107 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A involved_in IEA
ISO 		GO_REF:0000107
MGI:1857637|MGI:2158947|MGI:2687362 (PMID:30735130) 		Ensembl
RGD		 PMID:30735130 GO_REF:0000107 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISO MGI:1857637|MGI:2158947|MGI:2687362 (PMID:30735130) RGD PMID:30735130 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      signal transduction 7313
        cell surface receptor signaling pathway 2915
          semaphorin-plexin signaling pathway 54
            negative regulation of semaphorin-plexin signaling pathway 0
            positive regulation of semaphorin-plexin signaling pathway + 1
            regulation of semaphorin-plexin signaling pathway + 7
            semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis 0
            semaphorin-plexin signaling pathway involved in neuron projection guidance + 4
            semaphorin-plexin signaling pathway involved in outflow tract morphogenesis + 0
            semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance 0
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        signaling 7874
          signal transduction 7313
            cell surface receptor signaling pathway 2915
              semaphorin-plexin signaling pathway 54
                negative regulation of semaphorin-plexin signaling pathway 0
                positive regulation of semaphorin-plexin signaling pathway + 1
                regulation of semaphorin-plexin signaling pathway + 7
                semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis 0
                semaphorin-plexin signaling pathway involved in neuron projection guidance + 4
                semaphorin-plexin signaling pathway involved in outflow tract morphogenesis + 0
                semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance 0
paths to the root