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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular response to hypoxia
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Accession:GO:0071456 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
Comment:Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
Synonyms:exact_synonym: cellular response to hypoxic stress;   cellular response to lowered oxygen tension


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cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07054614.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Acaa2 acetyl-CoA acyltransferase 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:18371312)		 Ensembl
RGD		 PMID:18371312 GO_REF:0000107 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 involved_in ISO (PMID:18566576) RGD PMID:18566576 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Ado 2-aminoethanethiol dioxygenase involved_in ISO (PMID:31273118) RGD PMID:31273118 NCBI chr20:21,044,815...21,045,983
Ensembl chr20:21,044,555...21,049,235 		JBrowse link
G Adrb2 adrenoceptor beta 2 IDA RGD PMID:19098126 RGD:8548506 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Ak4 adenylate kinase 4 involved_in
acts_upstream_of		 ISO
ISS		 (PMID:30696468)
(PMID:19130895), (PMID:23474458), (PMID:26980435)
GO_REF:0000024		 RGD
UniProt		 PMID:19130895 PMID:23474458 PMID:26980435 PMID:30696468 GO_REF:0000024 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 IDA RGD PMID:20515660 RGD:5509097 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Angpt4 angiopoietin 4 involved_in ISO (PMID:12958144) RGD PMID:12958144 NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 IEP RGD PMID:19299913 RGD:5133278 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919 		JBrowse link
G Aqp1 aquaporin 1 involved_in ISO
ISS		 (PMID:18275976)
GO_REF:0000024		 RGD
UniProt		 PMID:18275976 GO_REF:0000024 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24462679)
GO_REF:0000107		 RGD
Ensembl		 PMID:24462679 GO_REF:0000107 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Asl argininosuccinate lyase IEP RGD PMID:11097477 RGD:1599264 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662 		JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b IEP RGD PMID:29300489 RGD:13792656 NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418 		JBrowse link
G Atp7a ATPase copper transporting alpha IEP RGD PMID:21346155 RGD:11341705 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G B3gat1 beta-1,3-glucuronyltransferase 1 IEP RGD PMID:21400481 RGD:14390075 NCBI chr 8:25,087,123...25,114,692
Ensembl chr 8:25,087,547...25,113,395 		JBrowse link
G Bad BCL2-associated agonist of cell death involved_in ISO
IEA
IBA		 (PMID:20810912)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:20810912 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in ISO
IEA		 (PMID:20810912)
GO_REF:0000107		 RGD
Ensembl		 PMID:20810912 GO_REF:0000107 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within
involved_in		 IEP
ISO
IEA		 with serum deprivation
(MGI:77298|PMID:7595537)
GO_REF:0000107		 RGD
Ensembl		 PMID:7595537 PMID:20669351 GO_REF:0000107 MGI:77298, RGD:11353793 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 IEP with serum deprivation RGD PMID:20669351 RGD:11353793 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdkrb2 bradykinin receptor B2 IEP RGD PMID:19565561 RGD:4891057 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Bnip3 BCL2 interacting protein 3 acts_upstream_of_or_within
involved_in		 IEP
ISO		 UniProtKB:O60238 (PMID:19273585)
(PMID:20436456)		 RGD PMID:19273585 PMID:20436456 PMID:17379825 RGD:9685412 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like acts_upstream_of_or_within ISO UniProtKB:Q12983 (PMID:19273585) RGD PMID:19273585 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Brip1 BRCA1 interacting helicase 1 IEP RGD PMID:12511571 RGD:11251702 NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324 		JBrowse link
G Casr calcium-sensing receptor IEP RGD PMID:21073657 RGD:7206834 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Cav1 caveolin 1 IEP RGD PMID:29069575 RGD:151347449 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cbs cystathionine beta synthase involved_in IDA PMID:20149843 UniProt PMID:20149843 RGD:8554341 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Ccn1 cellular communication network factor 1 IEP RGD PMID:30371213 RGD:329845516 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccna2 cyclin A2 IEP RGD PMID:25289051 RGD:10054493 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 IEP RGD PMID:12374461 RGD:2316579 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEP RGD PMID:28854428 RGD:152025191 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator IEP RGD PMID:12031707 RGD:8663470 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Clca1 chloride channel accessory 1 IEP RGD PMID:18616988 RGD:4188872 NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369 		JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 IEP RGD PMID:23303788 RGD:11344908 NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331 		JBrowse link
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 involved_in ISO
ISS		 (PMID:18752464)
(MGI:5543770|PMID:18752464)
GO_REF:0000024		 RGD
UniProt		 PMID:18752464 GO_REF:0000024 MGI:5543770 NCBI chr 1:135,300,048...135,407,688
Ensembl chr 1:135,300,461...135,409,760 		JBrowse link
G Cpeb2 cytoplasmic polyadenylation element binding protein 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5543770|PMID:18752464)
(PMID:18752464)		 UniProt
RGD		 PMID:18752464 GO_REF:0000024 MGI:5543770 NCBI chr14:67,787,503...67,839,973
Ensembl chr14:67,787,507...67,840,743 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO (MGI:4821502|PMID:20675597) RGD PMID:20675597 MGI:4821502 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cybb cytochrome b-245 beta chain IEP RGD PMID:21302291 RGD:11040609 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 IEP RGD PMID:18664364 RGD:150429768 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha IEP RGD PMID:24282625 RGD:9589039 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Drd1 dopamine receptor D1 IEP RGD PMID:20969567 RGD:7248614 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G E2f1 E2F transcription factor 1 IEP RGD PMID:19088195 RGD:2316261 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Edn1 endothelin 1 IEP RGD PMID:9551744 RGD:8662285 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:52,867,914...52,907,169
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G Egr1 early growth response 1 IEP RGD PMID:21220915 RGD:5131857 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 IDA RGD PMID:10100614 RGD:10401146 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eln elastin IEP RGD PMID:16055482 RGD:9585727 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G Endog endonuclease G IEP RGD PMID:17379825 RGD:9685412 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Eno1 enolase 1 involved_in IDA PMID:15459207 CAFA PMID:15459207 RGD:12793039 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Epas1 endothelial PAS domain protein 1 involved_in IEP
IBA
ISO
IEA
ISS		 PMID:21873635
(PMID:11573933)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:11573933 PMID:12099714 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:11041576, RGD:13792537 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha IEP RGD PMID:12752442 RGD:10401130 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Fabp1 fatty acid binding protein 1 involved_in ISO (PMID:16175609) RGD PMID:16175609 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fam162a family with sequence similarity 162, member A involved_in ISO
IBA		 (PMID:15082785)
(MGI:5319611|PMID:17316997)
PMID:21873635		 RGD PMID:15082785 PMID:17316997 PMID:21873635 MGI:5319611, RGD:13792537 NCBI chr11:64,680,937...64,711,239
Ensembl chr11:64,680,323...64,711,239 		JBrowse link
G Fas Fas cell surface death receptor IEP RGD PMID:12031707 RGD:8663470 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IEP RGD PMID:31093967 RGD:155882597 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 IEP RGD PMID:11981751 RGD:634296 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fmn2 formin 2 involved_in ISO (PMID:23375502) RGD PMID:23375502 NCBI chr13:86,454,256...86,771,437
Ensembl chr13:86,453,926...86,771,411 		JBrowse link
G Fndc1 fibronectin type III domain containing 1 acts_upstream_of_or_within IMP PMID:19723622 MGI PMID:19723622 RGD:8554041 NCBI chr 1:47,281,839...47,364,247
Ensembl chr 1:47,281,844...47,364,259 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP RGD PMID:8593588 RGD:151347626 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo3 forkhead box O3 IEP RGD PMID:24278276 RGD:10402204 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gata6 GATA binding protein 6 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21127043)		 Ensembl
RGD		 PMID:21127043 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Gnb1 G protein subunit beta 1 acts_upstream_of_or_within IDA PMID:19723622 MGI PMID:19723622 RGD:8554041 NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124 		JBrowse link
G Gngt1 G protein subunit gamma transducin 1 acts_upstream_of_or_within IDA PMID:19723622 MGI PMID:19723622 RGD:8554041 NCBI chr 4:32,006,267...32,009,252
Ensembl chr 4:32,006,267...32,009,252 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within
involved_in		 IEP
ISO
ISS
IBA
IMP		 MGI:101884|MGI:2676890|MGI:3618742 (MGI:5528778|PMID:24011070)
GO_REF:0000024
(PMID:11573933), (PMID:19528298), (PMID:19782034), (PMID:20810912), (PMID:20889502)
PMID:21873635		 RGD
UniProt		 PMID:11573933 PMID:19528298 PMID:19782034 PMID:20810912 PMID:20889502 More... GO_REF:0000024 MGI:5528778, RGD:9068456, RGD:13792537, RGD:9068884 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha NOT|involved_in ISO
IBA		 (PMID:11573933)
PMID:21873635		 RGD PMID:11573933 PMID:21873635 RGD:13792537 NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758 		JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A acts_upstream_of_or_within ISO (MGI:3654896|PMID:16815968), (MGI:5306879|PMID:21856340), (MGI:5643884|PMID:25683712) RGD PMID:16815968 PMID:21856340 PMID:25683712 MGI:3654896 MGI:5306879 MGI:5643884 NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443 		JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated involved_in ISO (PMID:10690527) RGD PMID:10690527 NCBI chr 4:57,871,076...57,875,206
Ensembl chr 4:57,871,110...57,874,557 		JBrowse link
G Hmox1 heme oxygenase 1 involved_in ISO
IEA		 (PMID:12511571)
GO_REF:0000107		 RGD
Ensembl		 PMID:12511571 GO_REF:0000107 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha IEP RGD PMID:24177414 RGD:10445837 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hp1bp3 heterochromatin protein 1, binding protein 3 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:25100860)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:25100860 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:150,435,781...150,463,004
Ensembl chr 5:150,433,740...150,463,000 		JBrowse link
G Hyou1 hypoxia up-regulated 1 involved_in ISO
IEA
IBA		 (PMID:10837345), (PMID:9020069)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:9020069 PMID:10837345 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP RGD PMID:20631551 RGD:8662392 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il7 interleukin 7 IEP RGD PMID:19055876 RGD:10402937 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 IEP RGD PMID:15793310 RGD:1579809 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Ireb2 iron responsive element binding protein 2 IEP RGD PMID:22159112 RGD:6893269 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 IEP RGD PMID:17285299 RGD:6482794 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 IEP RGD PMID:17285299 RGD:6482794 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IEP RGD PMID:8593588 RGD:151347626 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit IEP RGD PMID:8593588 RGD:151347626 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit IEP RGD PMID:8593588 RGD:151347626 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 involved_in IDA PMID:25352783 UniProt PMID:25352783 RGD:10047379 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 IEP RGD PMID:24705172 RGD:9831164 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 IMP RGD PMID:12215606 RGD:2316539 NCBI chr 6:25,761,487...25,799,153
Ensembl chr 6:25,763,228...25,799,153 		JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 IEP RGD PMID:19461047 RGD:10412041 NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798 		JBrowse link
G Kdm6a lysine demethylase 6A IEP RGD PMID:30887465 RGD:151665136 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Lmna lamin A/C involved_in ISO
IEA		 (PMID:20810912)
GO_REF:0000107		 RGD
Ensembl		 PMID:20810912 GO_REF:0000107 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G LOC120095320 protein FAM162A-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:36,389,447...36,391,357
Ensembl chr10:36,390,113...36,390,613 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:20810912) RGD PMID:20810912 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mdm4 MDM4 regulator of p53 involved_in ISO
IEA		 (PMID:20810912)
GO_REF:0000107		 RGD
Ensembl		 PMID:20810912 GO_REF:0000107 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226 		JBrowse link
G Mfn1 mitofusin 1 IEP RGD PMID:27833818 RGD:12910766 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mfn2 mitofusin 2 IEP RGD PMID:28478070 RGD:12910733 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mgarp mitochondria-localized glutamic acid-rich protein involved_in ISO (MGI:3850758|PMID:19528298) RGD PMID:19528298 MGI:3850758 NCBI chr 2:135,431,283...135,439,425
Ensembl chr 2:135,431,283...135,439,612 		JBrowse link
G Mief1 mitochondrial elongation factor 1 IEP RGD PMID:25911325 RGD:12880381 NCBI chr 7:111,786,630...111,802,220
Ensembl chr 7:111,786,709...111,802,220 		JBrowse link
G Mif macrophage migration inhibitory factor IEP RGD PMID:19462902 RGD:4890975 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mir126b microRNA 126b involved_in ISO (PMID:28578351) RGD PMID:28578351 NCBI chr 3:9,415,087...9,415,159 JBrowse link
G Mir140 microRNA 140 involved_in ISO
IEP		 (PMID:27021683) RGD PMID:27021683 PMID:28922712 RGD:329347824 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir143 microRNA 143 IEP RGD PMID:28887629 RGD:155882580 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110 		JBrowse link
G Mir146a microRNA 146a involved_in ISO (PMID:18801740) RGD PMID:18801740 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir17 microRNA 17 involved_in ISO (PMID:27640178) RGD PMID:27640178 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir199a2 microRNA 199a-2 acts_upstream_of_or_within ISO MGI:101884|MGI:106918|MGI:2676890 (MGI:5528778|PMID:24011070) RGD PMID:24011070 MGI:5528778 NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063 		JBrowse link
G Mir20a microRNA 20a involved_in ISO (PMID:31368162) RGD PMID:31368162 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir210 microRNA 210 IEP RGD PMID:33234216 RGD:155260322 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mir214 microRNA 214 acts_upstream_of_or_within
involved_in		 ISO MGI:101884|MGI:106918|MGI:3618742 (MGI:5528778|PMID:24011070)
(PMID:27144530)		 RGD PMID:24011070 PMID:27144530 MGI:5528778 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir222 microRNA 222 IEP RGD PMID:28854428 RGD:152025191 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mir223 microRNA 223 IEP RGD PMID:29608885 RGD:21408565 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mir320a microRNA 320a IMP RGD PMID:30181740 RGD:155882545 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mir34a microRNA 34a involved_in ISO (PMID:27302634) RGD PMID:27302634 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Mir448 microRNA 448 involved_in ISO (PMID:33108349) RGD PMID:33108349 NCBI chr  X:110,829,918...110,830,029
Ensembl chr  X:110,829,918...110,830,029 		JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor IEP RGD PMID:15642952 RGD:10449018 NCBI chr 5:131,973,897...131,987,472
Ensembl chr 5:131,973,895...131,986,797 		JBrowse link
G Mst1 macrophage stimulating 1 IEP RGD PMID:23647599 RGD:10448278 NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416 		JBrowse link
G Mt3 metallothionein 3 involved_in ISO (PMID:18206644) RGD PMID:18206644 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3654795|PMID:16915281)		 UniProt
Ensembl
RGD		 PMID:16915281 GO_REF:0000024 GO_REF:0000107 MGI:3654795 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO (PMID:15459207) RGD PMID:15459207 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myocd myocardin IEP RGD PMID:20621093 RGD:5132874 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
G Ndnf neuron-derived neurotrophic factor involved_in ISO (PMID:24706764) RGD PMID:24706764 NCBI chr 4:94,944,749...94,987,414
Ensembl chr 4:94,944,360...94,981,873 		JBrowse link
G Ndp norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO MGI:4414794 (MGI:6297146|PMID:30988181) RGD PMID:30988181 MGI:6297146 NCBI chr  X:5,796,487...5,820,934
Ensembl chr  X:5,796,487...5,820,934 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 involved_in ISO
IEA		 (PMID:20810912)
GO_REF:0000107		 RGD
Ensembl		 PMID:20810912 GO_REF:0000107 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 IEP RGD PMID:23904790 RGD:10412703 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nkx3-1 NK3 homeobox 1 involved_in ISO (PMID:21056661) RGD PMID:21056661 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441 		JBrowse link
G Nog noggin IEP RGD PMID:25740156 RGD:12801489 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IDA PMID:22082675 UniProt PMID:22082675 RGD:10047303 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Nop53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:22522597) RGD PMID:22522597 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902 		JBrowse link
G Notch1 notch receptor 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5319604|PMID:18299578)		 UniProt
RGD		 PMID:18299578 GO_REF:0000024 MGI:5319604 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Npepps aminopeptidase puromycin sensitive involved_in ISO (PMID:21056661) RGD PMID:21056661 NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967 		JBrowse link
G Npm1 nucleophosmin 1 IEP RGD PMID:21444791 RGD:11535018 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IEP RGD PMID:27833818 RGD:12910766 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Oprd1 opioid receptor, delta 1 involved_in ISO (PMID:24613828) RGD PMID:24613828 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta involved_in ISO (PMID:12095988) RGD PMID:12095988 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Palld palladin, cytoskeletal associated protein IEP RGD PMID:16481593 RGD:2325785 NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337 		JBrowse link
G Park7 Parkinsonism associated deglycase IEP RGD PMID:29069575 RGD:151347449 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IEP RGD PMID:24177414 RGD:10445837 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 IEP RGD PMID:23647599 RGD:10448278 NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 involved_in ISO (PMID:11130727) RGD PMID:11130727 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Phb2 prohibitin 2 IEP RGD PMID:25031298 RGD:12903263 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:24553947)
(MGI:5558956|PMID:24553947)		 RGD PMID:24553947 MGI:5558956 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Plau plasminogen activator, urokinase IEP RGD PMID:19490965 RGD:7241802 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:14699081), (PMID:20810912) RGD PMID:14699081 PMID:20810912 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta acts_upstream_of_or_within ISO MGI:106918|MGI:2676890|MGI:3618742 (MGI:5528778|PMID:24011070) RGD PMID:24011070 MGI:5528778 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in IDA PMID:29695452 BHF-UCL PMID:29695452 RGD:150521636 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEP RGD PMID:22527940 RGD:7242177 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IEP RGD PMID:17720864 RGD:2316813 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkce protein kinase C, epsilon acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3776183|PMID:18070622)
GO_REF:0000107		 RGD
Ensembl		 PMID:18070622 GO_REF:0000107 MGI:3776183 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Pten phosphatase and tensin homolog acts_upstream_of_or_within ISO (MGI:5584033|PMID:24875179) RGD PMID:24875179 MGI:5584033 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgis prostaglandin I2 synthase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:21296955)		 UniProt
Ensembl
RGD		 PMID:21296955 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in ISO (PMID:21296955) RGD PMID:21296955 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptn pleiotrophin IEP RGD PMID:16226713 PMID:17925408 RGD:9834996, RGD:10044023 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Rgcc regulator of cell cycle involved_in ISO (PMID:19652095) RGD PMID:19652095 NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141 		JBrowse link
G Rnf146 ring finger protein 146 IEP RGD PMID:26218637 RGD:13524866 NCBI chr 1:28,458,864...28,475,758
Ensembl chr 1:28,458,887...28,475,923 		JBrowse link
G Rora RAR-related orphan receptor A involved_in ISO (PMID:18658046) RGD PMID:18658046 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Rtn4 reticulon 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6274961|PMID:27763637)		 UniProt
RGD		 PMID:27763637 GO_REF:0000024 MGI:6274961 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G S100b S100 calcium binding protein B IEP RGD PMID:19910580 RGD:2325647 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 involved_in IDA PMID:28029095 UniProt PMID:28029095 RGD:14390052 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214 		JBrowse link
G Sdhd succinate dehydrogenase complex subunit D acts_upstream_of_or_within ISO MGI:3526521 (MGI:3525749|PMID:15572694) RGD PMID:15572694 MGI:3525749 NCBI chr 8:50,944,717...50,954,298
Ensembl chr 8:50,944,704...50,954,238 		JBrowse link
G Serpine1 serpin family E member 1 IEP RGD PMID:10590062 RGD:8547811 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in ISO
IEA		 (PMID:11932307)
GO_REF:0000107		 RGD
Ensembl		 PMID:11932307 GO_REF:0000107 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (PMID:20620956)
GO_REF:0000107		 RGD
Ensembl		 PMID:20620956 GO_REF:0000107 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 involved_in ISO
ISS		 (PMID:24681946)
GO_REF:0000024		 RGD
UniProt		 PMID:24681946 GO_REF:0000024 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt4 sirtuin 4 IEP RGD PMID:24029877 RGD:9586053 NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 IEP RGD PMID:21325818 RGD:5688411 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 IEP RGD PMID:10646513 RGD:1598899 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 IDA RGD PMID:20868366 RGD:7349316 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 IEP RGD PMID:17394575 RGD:1642726 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Slc8a3 solute carrier family 8 member A3 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5693358|PMID:24101730)		 UniProt
Ensembl
RGD		 PMID:24101730 GO_REF:0000024 GO_REF:0000107 MGI:5693358 NCBI chr 6:100,874,359...101,007,989
Ensembl chr 6:100,874,369...101,007,508 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 IDA RGD PMID:20868366 RGD:7349316 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IEP RGD PMID:20380727 RGD:2324980 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stc1 stanniocalcin 1 IEP RGD PMID:15485913 RGD:2324700 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264 		JBrowse link
G Stc2 stanniocalcin 2 IEP RGD PMID:15485913 RGD:2324700 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IDA PMID:19953350 ARUK-UCL PMID:19953350 RGD:13507303 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 IEP RGD PMID:17289031 RGD:9587773 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase acts_upstream_of_or_within ISO (PMID:21402781) RGD PMID:21402781 NCBI chr  X:14,421,028...14,434,216
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 acts_upstream_of_or_within ISO (PMID:21402781) RGD PMID:21402781 NCBI chr  X:141,793,695...141,795,558 JBrowse link
G Suv39h2 SUV39H2 histone lysine methyltransferase acts_upstream_of_or_within ISO (PMID:21402781) RGD PMID:21402781 NCBI chr17:74,756,290...74,775,332
Ensembl chr17:74,756,306...74,775,332 		JBrowse link
G Tbl2 transducin (beta)-like 2 involved_in ISO (PMID:25393282) RGD PMID:25393282 NCBI chr12:21,517,600...21,532,114
Ensembl chr12:21,520,682...21,531,896 		JBrowse link
G Terc telomerase RNA component involved_in ISO (PMID:11313459) RGD PMID:11313459 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Tert telomerase reverse transcriptase involved_in IEP
ISO		 (PMID:11313459) RGD PMID:11313459 PMID:24376652 RGD:11038675 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO (PMID:31368162) RGD PMID:31368162 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase involved_in ISO (PMID:23185017) RGD PMID:23185017 NCBI chr 4:159,927,138...159,946,094
Ensembl chr 4:159,927,139...159,946,029 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 IEP RGD PMID:28854428 RGD:152025191 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO
IEP		 (PMID:20810912) RGD PMID:20810912 PMID:17289031 RGD:9587773 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IMP PMID:31900229 ARUK-UCL PMID:31900229 RGD:126781734 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 IEP RGD PMID:19889962 RGD:7247600 NCBI chr 8:96,263,322...96,314,197
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 IEP RGD PMID:19889962 RGD:7247600 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:18297062)
(MGI:5284765|PMID:18297062)		 RGD PMID:18297062 MGI:5284765 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in ISO
ISS
IEA		 (PMID:12095988)
GO_REF:0000024
GO_REF:0000107		 RGD
HGNC
Ensembl		 PMID:12095988 GO_REF:0000024 GO_REF:0000107 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090 		JBrowse link
G Ucn2 urocortin 2 IEP RGD PMID:14519439 RGD:2306174 NCBI chr 8:109,637,624...109,639,173
Ensembl chr 8:109,638,285...109,639,172 		JBrowse link
G Ucn3 urocortin 3 IEP RGD PMID:14519439 RGD:2306174 NCBI chr17:66,309,952...66,315,571
Ensembl chr17:66,309,371...66,315,990 		JBrowse link
G Vasn vasorin acts_upstream_of_or_within ISO MGI:5140849 (MGI:5014460|PMID:21658601) RGD PMID:21658601 MGI:5014460 NCBI chr10:10,917,750...10,928,259
Ensembl chr10:10,917,605...10,928,357 		JBrowse link
G Vegfa vascular endothelial growth factor A acts_upstream_of_or_within ISO (PMID:10575000) RGD PMID:10575000 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vldlr very low density lipoprotein receptor IDA RGD PMID:19233325 RGD:2324641 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 involved_in ISO
ISS		 (PMID:21832157)
GO_REF:0000024		 RGD
UniProt		 PMID:21832157 GO_REF:0000024 NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748 		JBrowse link
hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cybb cytochrome b-245 beta chain IMP RGD PMID:21302291 RGD:11040609 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:60478|PMID:8470821)		 Ensembl
RGD		 PMID:8470821 GO_REF:0000107 MGI:60478 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Mir210 microRNA 210 involved_in ISO (PMID:19782034) RGD PMID:19782034 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:21763680)		 UniProt
Ensembl
RGD		 PMID:21763680 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:18718909) RGD PMID:18718909 NCBI chr  X:58,477,471...58,553,932
Ensembl chr  X:58,486,554...58,553,557 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of ISO MGI:2136645|MGI:3608931 (MGI:5618205|PMID:25186293) RGD PMID:25186293 MGI:5618205 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
intrinsic apoptotic signaling pathway in response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO
IEA		 MGI:1857283 (MGI:3700897|PMID:17189429)
GO_REF:0000107		 RGD
Ensembl		 PMID:17189429 GO_REF:0000107 MGI:3700897 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:20436456) RGD PMID:20436456 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4867601|PMID:20935145)
GO_REF:0000107		 RGD
Ensembl		 PMID:20935145 GO_REF:0000107 MGI:4867601 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
negative regulation of cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Daxx death-domain associated protein IMP cell death RGD PMID:17289031 RGD:9587773 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 involved_in ISO (PMID:24895913) RGD PMID:24895913 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339 		JBrowse link
G Drd1 dopamine receptor D1 IMP cell death RGD PMID:27638511 RGD:13506952 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 IMP cell death RGD PMID:27638511 RGD:13506952 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Epha4 Eph receptor A4 acts_upstream_of_or_within ISO (PMID:31150684) RGD PMID:31150684 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 IMP cell death RGD PMID:24048861 RGD:10412727 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase IMP cell death RGD PMID:18539296 RGD:9590185 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146 		JBrowse link
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eno1 enolase 1 involved_in ISO UniProtKB:Q01986 (PMID:15459207) RGD PMID:15459207 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Hyou1 hypoxia up-regulated 1 involved_in IBA
IEA
ISO
IDA		 PMID:21873635
GO_REF:0000107
(PMID:10037731)
PMID:11231630		 Ensembl
RGD		 PMID:10037731 PMID:21873635 PMID:11231630 GO_REF:0000107, RGD:13792537, RGD:10047348 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Kdm6a lysine demethylase 6A IMP RGD PMID:30887465 RGD:151665136 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 involved_in IGI
IMP		 PMID:15459207 CAFA PMID:15459207 PMID:15459207 RGD:12793039, RGD:12793039 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IDA PMID:10590251 UniProt PMID:10590251 RGD:10047155 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in IEA
ISO		 GO_REF:0000107
(MGI:6444553|PMID:30496354)		 Ensembl
RGD		 PMID:30496354 GO_REF:0000107 MGI:6444553 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (MGI:5558956|PMID:24553947) RGD PMID:24553947 MGI:5558956 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in ISO (PMID:21075086) RGD PMID:21075086 NCBI chr 7:130,512,428...130,543,637
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
negative regulation of hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Commd1 copper metabolism domain containing 1 acts_upstream_of_or_within ISO MGI:3714157 (MGI:3713589|PMID:17371845) RGD PMID:17371845 MGI:3713589 NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO MGI:2136645|MGI:3608931 (MGI:5618205|PMID:25186293) RGD PMID:25186293 MGI:5618205 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 involved_in ISO (PMID:22735262) RGD PMID:22735262 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Sirt2 sirtuin 2 involved_in ISO
IEA
ISS		 (PMID:24681946)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:24681946 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor involved_in ISO (PMID:11641274) RGD PMID:11641274 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
positive regulation of cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt3a DNA methyltransferase 3 alpha IMP oxygen-glucose deprivation-induced cell death RGD PMID:23516428 RGD:9589049 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Ep300 E1A binding protein p300 IMP reduced metabolism in hypoxia-treated PC12 cells
reduced metabolism in hypoxia mimic CoCl2-treated PC12 cells		 RGD PMID:19103185 PMID:18586071 RGD:2311713, RGD:2311718 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 IMP RGD PMID:24705172 RGD:9831164 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435 		JBrowse link
G Mir145 microRNA 145 acts_upstream_of_or_within ISO (PMID:31150684) RGD PMID:31150684 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
positive regulation of hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rwdd3 RWD domain containing 3 involved_in
acts_upstream_of_or_within		 ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
PMID:21873635
GO_REF:0000002
(MGI:5569907|PMID:22009797)
(PMID:23469069)		 UniProt
Ensembl
InterPro
RGD		 PMID:22009797 PMID:23469069 PMID:21873635 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 MGI:5569907, RGD:13792537 NCBI chr 2:209,233,622...209,254,842
Ensembl chr 2:209,233,622...209,248,853 		JBrowse link
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plk3 polo-like kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20889502)		 UniProt
RGD		 PMID:20889502 GO_REF:0000024 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
G Sirt2 sirtuin 2 involved_in ISO
ISS
IEA		 (PMID:24681946)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:24681946 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19652095), (PMID:22735262), (PMID:24681946)		 UniProt
Ensembl
RGD		 PMID:19652095 PMID:22735262 PMID:24681946 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (PMID:24844779) RGD PMID:24844779 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (PMID:23303788) RGD PMID:23303788 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4867601|PMID:20935145)
GO_REF:0000107		 RGD
Ensembl		 PMID:20935145 GO_REF:0000107 MGI:4867601 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO
IEA		 (PMID:19652095)
GO_REF:0000107		 RGD
Ensembl		 PMID:19652095 GO_REF:0000107 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
regulation of cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ajuba ajuba LIM protein involved_in ISO (PMID:22286099) RGD PMID:22286099 NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021 		JBrowse link
G Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 involved_in ISO (PMID:23303788) RGD PMID:23303788 NCBI chr12:26,828,738...26,834,762
Ensembl chr12:26,828,736...26,834,755 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP RGD PMID:18054269 RGD:9068899 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Mir210 microRNA 210 involved_in ISO (PMID:20436681), (PMID:26780211) RGD PMID:20436681 PMID:26780211 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO (MGI:6271078|PMID:29353861) RGD PMID:29353861 MGI:6271078 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IMP RGD PMID:19450559 RGD:7242910 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Usp19 ubiquitin specific peptidase 19 involved_in ISO
IEA
ISS		 (PMID:22128162)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:22128162 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:109,190,727...109,201,761
Ensembl chr 8:109,190,724...109,201,741 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor involved_in ISO (PMID:10205047) RGD PMID:10205047 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
regulation of transcription from RNA polymerase II promoter in response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr1 early growth response 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3847400|PMID:18323529)		 Ensembl
RGD		 PMID:18323529 GO_REF:0000107 MGI:3847400 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Stox1 storkhead box 1 involved_in ISO (PMID:24738702) RGD PMID:24738702 NCBI chr20:30,598,656...30,666,371
Ensembl chr20:30,598,168...30,666,939 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    response to stimulus 10522
      response to stress 4190
        response to hypoxia 478
          cellular response to hypoxia 217
            hypoxia-inducible factor-1alpha signaling pathway + 8
            intrinsic apoptotic signaling pathway in response to hypoxia + 11
            negative regulation of cellular response to hypoxia + 17
            positive regulation of cellular response to hypoxia 4
            positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia 2
            regulation of cellular response to hypoxia + 28
            regulation of transcription from RNA polymerase II promoter in response to hypoxia + 10
Path 2
Term Annotations click to browse term
  biological_process 19818
    cellular process 17392
      cellular response to stimulus 8857
        cellular response to chemical stimulus 3240
          cellular response to oxygen levels 270
            cellular response to decreased oxygen levels 250
              cellular response to hypoxia 217
                hypoxia-inducible factor-1alpha signaling pathway + 8
                intrinsic apoptotic signaling pathway in response to hypoxia + 11
                negative regulation of cellular response to hypoxia + 17
                positive regulation of cellular response to hypoxia 4
                positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia 2
                regulation of cellular response to hypoxia + 28
                regulation of transcription from RNA polymerase II promoter in response to hypoxia + 10
paths to the root