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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular response to alkaloid
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Accession:GO:0071312 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.


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cellular response to alkaloid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IEP coptisine, berberine, palmatine RGD PMID:20410605 RGD:8657336 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Bcl2l1 Bcl2-like 1 acts_upstream_of_or_within ISO (PMID:15231831) RGD PMID:15231831 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Ddc dopa decarboxylase IEP asimilobine RGD PMID:18696327 RGD:5129084 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B involved_in ISO
ISS		 (PMID:1315531)
GO_REF:0000024		 RGD
UniProt		 PMID:1315531 GO_REF:0000024 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP berberine RGD PMID:20674665 RGD:4145373 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Mdm2 MDM2 proto-oncogene IEP camptothecin RGD PMID:19136059 RGD:2317366 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mmp1 matrix metallopeptidase 1 IEP berberine RGD PMID:21108488 RGD:7207365 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Rad51 RAD51 recombinase acts_upstream_of_or_within ISO MGI:5444025|MGI:5444027 (PMID:22778135) RGD PMID:22778135 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Star steroidogenic acute regulatory protein IEP evodiamine, rutaecarpine RGD PMID:19639602 RGD:4145624 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Th tyrosine hydroxylase IEP asimilobine RGD PMID:18696327 RGD:5129084 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 involved_in IMP PMID:17582331 UniProt PMID:17582331 RGD:8553505 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
cellular response to caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1s calcium voltage-gated channel subunit alpha1 S involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr13:47,493,949...47,564,194
Ensembl chr13:47,493,949...47,564,318 		JBrowse link
G Casq2 calsequestrin 2 involved_in ISO
IEA		 (PMID:16908766)
GO_REF:0000107		 RGD
Ensembl		 PMID:16908766 GO_REF:0000107 NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267 		JBrowse link
G Chek1 checkpoint kinase 1 IEP RGD PMID:11278490 RGD:2316109 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 involved_in ISO (PMID:22406107) RGD PMID:22406107 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:195,566,701...195,572,149
Ensembl chr 2:195,566,701...195,572,203 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEP RGD PMID:17516843 RGD:10059651 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ryr1 ryanodine receptor 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:7621815)
GO_REF:0000024
(PMID:16163667), (PMID:26115329)		 Ensembl
RGD
UniProt		 PMID:7621815 PMID:16163667 PMID:26115329 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Ryr2 ryanodine receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 GO_REF:0000107
(PMID:22406107), (PMID:9628868)
(PMID:12089338)
GO_REF:0000024
(PMID:12919952)		 Ensembl
RGD
UniProt		 PMID:9628868 PMID:12089338 PMID:12919952 PMID:22406107 GO_REF:0000024 GO_REF:0000107 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Selenon selenoprotein N acts_upstream_of_or_within ISO (PMID:23325319) RGD PMID:23325319 NCBI chr 5:146,748,638...146,764,656
Ensembl chr 5:146,748,652...146,763,059 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in ISO (PMID:10967099) RGD PMID:10967099 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Tmem38a transmembrane protein 38a involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1098718 (PMID:17611541)		 Ensembl
RGD		 PMID:17611541 GO_REF:0000107 NCBI chr16:17,258,160...17,274,204
Ensembl chr16:17,258,164...17,273,415 		JBrowse link
G Tmem38b transmembrane protein 38B acts_upstream_of_or_within ISO MGI:1921416 (PMID:17611541) RGD PMID:17611541 NCBI chr 5:68,460,304...68,496,026
Ensembl chr 5:68,460,304...68,496,025 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IEP RGD PMID:22319196 RGD:10043374 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
cellular response to camptothecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase involved_in ISO (PMID:23509288) RGD PMID:23509288 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Fancb FA complementation group B acts_upstream_of_or_within ISO MGI:2156841 (PMID:25520194) RGD PMID:25520194 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192 		JBrowse link
G Rad51 RAD51 recombinase involved_in ISO (PMID:23509288) RGD PMID:23509288 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Recql5 RecQ like helicase 5 acts_upstream_of_or_within ISO MGI:2448558 (PMID:25520194) RGD PMID:25520194 NCBI chr10:101,126,544...101,165,739
Ensembl chr10:101,126,547...101,165,652 		JBrowse link
G Spidr scaffold protein involved in DNA repair involved_in ISO (PMID:23509288) RGD PMID:23509288 NCBI chr11:84,766,593...85,007,597
Ensembl chr11:84,766,593...85,007,600 		JBrowse link
cellular response to cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccna2 cyclin A2 IEP RGD PMID:18593214 RGD:10054470 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Comt catechol-O-methyltransferase acts_upstream_of_or_within ISO MGI:2178542 (PMID:17881525) RGD PMID:17881525 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Crh corticotropin releasing hormone involved_in IDA PMID:14751291 UniProt PMID:14751291 RGD:8553798 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein involved_in IDA PMID:14751291 UniProt PMID:14751291 RGD:8553798 NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 acts_upstream_of_or_within ISO (PMID:24584053) RGD PMID:24584053 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B acts_upstream_of_or_within ISO MGI:3799291 (PMID:18496528) RGD PMID:18496528 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in ISO (PMID:27208619) RGD PMID:27208619 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:27208619)		 Ensembl
RGD		 PMID:27208619 GO_REF:0000107 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:27208619)		 Ensembl
RGD		 PMID:27208619 GO_REF:0000107 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
G Tgm2 transglutaminase 2 involved_in ISO
IEA		 (PMID:32273471)
GO_REF:0000107		 RGD
Ensembl		 PMID:32273471 GO_REF:0000107 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
cellular response to isoquinoline alkaloid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr1 early growth response 1 IEP berberine RGD PMID:16448624 RGD:5131909 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IDA bicuculline RGD PMID:22262897 RGD:12790719 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
cellular response to morphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy8 adenylate cyclase 8 involved_in IEA
IDA
ISS
ISO		 GO_REF:0000107
PMID:16186630
GO_REF:0000024
(PMID:18222416)		 Ensembl
UniProt
RGD		 PMID:18222416 PMID:16186630 GO_REF:0000024 GO_REF:0000107, RGD:13825193 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Aif1 allograft inflammatory factor 1 IEP morphine RGD PMID:19176808 RGD:2313012 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Atg7 autophagy related 7 IEP RGD PMID:23800874 RGD:11557986 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP RGD PMID:20578038 RGD:4889899 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 IEP RGD PMID:18178009 RGD:6483056 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Oprm1 opioid receptor, mu 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B involved_in ISS
ISO		 GO_REF:0000024
(PMID:18439408)		 UniProt
RGD		 PMID:18439408 GO_REF:0000024 NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083 		JBrowse link
G Ptk2 protein tyrosine kinase 2 IEP RGD PMID:26821693 RGD:401959306 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G RT1-Bb RT1 class II, locus Bb IEP RGD PMID:14742686 RGD:7488923 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
cellular response to staurosporine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 involved_in ISO (PMID:22253444) RGD PMID:22253444 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 involved_in ISO
IEA		 (PMID:22253444)
GO_REF:0000107		 RGD
Ensembl		 PMID:22253444 GO_REF:0000107 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 involved_in ISO (PMID:22253444) RGD PMID:22253444 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cpe carboxypeptidase E IMP RGD PMID:25426952 RGD:405650601 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Plau plasminogen activator, urokinase IEP RGD PMID:19137075 RGD:7241807 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Slc34a1 solute carrier family 34 member 1 IEP RGD PMID:10332085 RGD:7243183 NCBI chr17:9,218,876...9,233,852
Ensembl chr17:9,218,876...9,233,852 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    response to stimulus 10795
      response to chemical 5901
        response to nitrogen compound 1550
          response to alkaloid 193
            cellular response to alkaloid 55
              cellular response to caffeine + 13
              cellular response to camptothecin 5
              cellular response to cocaine 10
              cellular response to isoquinoline alkaloid + 11
              cellular response to staurosporine 6
              cellular response to tropane 0
paths to the root