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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular response to alkaloid
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Accession:GO:0071312 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.


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cellular response to alkaloid term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IEP coptisine, berberine, palmatine RGD PMID:20410605 RGD:8657336 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Bcl2l1 Bcl2-like 1 ISO (MGI:3057092|PMID:15231831) RGD PMID:15231831 MGI:3057092 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Ddc dopa decarboxylase IEP asimilobine RGD PMID:18696327 RGD:5129084 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO
ISS
(PMID:1315531)
GO_REF:0000024
RGD
UniProt
PMID:1315531 GO_REF:0000024 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP berberine RGD PMID:20674665 RGD:4145373 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Mdm2 MDM2 proto-oncogene IEP camptothecin RGD PMID:19136059 RGD:2317366 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mmp1 matrix metallopeptidase 1 IEP berberine RGD PMID:21108488 RGD:7207365 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Rad51 RAD51 recombinase ISO MGI:5444025|MGI:5444027 (MGI:5442243|PMID:22778135) RGD PMID:22778135 MGI:5442243 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Star steroidogenic acute regulatory protein IEP evodiamine, rutaecarpine RGD PMID:19639602 RGD:4145624 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Th tyrosine hydroxylase IEP asimilobine RGD PMID:18696327 RGD:5129084 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP PMID:17582331 UniProt PMID:17582331 RGD:8553505 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
cellular response to caffeine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1s calcium voltage-gated channel subunit alpha1 S ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr13:52,889,570...52,964,558
Ensembl chr13:52,889,737...52,964,155
JBrowse link
G Casq2 calsequestrin 2 ISO
IEA
(PMID:16908766)
GO_REF:0000107
RGD
Ensembl
PMID:16908766 GO_REF:0000107 NCBI chr 2:204,512,361...204,568,643
Ensembl chr 2:204,512,302...204,568,656
JBrowse link
G Chek1 checkpoint kinase 1 IEP RGD PMID:11278490 RGD:2316109 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Gstm2 glutathione S-transferase mu 2 ISO (PMID:22406107) RGD PMID:22406107 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEP RGD PMID:17516843 RGD:10059651 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ryr1 ryanodine receptor 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:74313|PMID:7621815)
(PMID:16163667), (PMID:26115329)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:7621815 PMID:16163667 PMID:26115329 GO_REF:0000024 GO_REF:0000107 MGI:74313 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
JBrowse link
G Ryr2 ryanodine receptor 2 ISO
ISS
IEA
(PMID:12919952)
(MGI:1267127|PMID:9628868), (MGI:2182484|PMID:12089338), (MGI:5431202|PMID:22406107)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:9628868 PMID:12089338 PMID:12919952 PMID:22406107 GO_REF:0000024 GO_REF:0000107 MGI:1267127 MGI:2182484 MGI:5431202 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Selenon selenoprotein N ISO (MGI:5494499|PMID:23325319) RGD PMID:23325319 MGI:5494499 NCBI chr 5:152,748,497...152,765,489
Ensembl chr 5:152,750,284...152,762,165
JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO (MGI:1927695|PMID:10967099) RGD PMID:10967099 MGI:1927695 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Tmem38a transmembrane protein 38a IEA
ISO
GO_REF:0000107
MGI:1098718 (MGI:3715564|PMID:17611541)
Ensembl
RGD
PMID:17611541 GO_REF:0000107 MGI:3715564 NCBI chr16:18,960,197...18,974,942
Ensembl chr16:18,959,315...18,974,770
JBrowse link
G Tmem38b transmembrane protein 38B ISO MGI:1921416 (MGI:3715564|PMID:17611541) RGD PMID:17611541 MGI:3715564 NCBI chr 5:70,639,156...70,675,055
Ensembl chr 5:70,639,156...70,675,054
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IEP RGD PMID:22319196 RGD:10043374 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
cellular response to camptothecin term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blm BLM RecQ like helicase ISO (PMID:23509288) RGD PMID:23509288 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
JBrowse link
G Fancb FA complementation group B ISO MGI:2156841 (MGI:5648586|PMID:25520194) RGD PMID:25520194 MGI:5648586 NCBI chr  X:31,124,018...31,140,790
Ensembl chr  X:31,124,018...31,140,711
JBrowse link
G Rad51 RAD51 recombinase ISO (PMID:23509288) RGD PMID:23509288 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Recql5 RecQ like helicase 5 ISO MGI:2448558 (MGI:5648586|PMID:25520194) RGD PMID:25520194 MGI:5648586 NCBI chr10:104,443,735...104,482,889
Ensembl chr10:104,443,736...104,482,838
JBrowse link
G Spidr scaffold protein involved in DNA repair ISO (PMID:23509288) RGD PMID:23509288 NCBI chr11:89,009,931...89,260,361
Ensembl chr11:89,009,931...89,260,297
JBrowse link
cellular response to cocaine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccna2 cyclin A2 IEP RGD PMID:18593214 RGD:10054470 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Crh corticotropin releasing hormone IDA PMID:14751291 UniProt PMID:14751291 RGD:8553798 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhbp corticotropin releasing hormone binding protein IDA PMID:14751291 UniProt PMID:14751291 RGD:8553798 NCBI chr 2:25,141,471...25,153,334
Ensembl chr 2:25,141,471...25,153,334
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 ISO (MGI:5577209|PMID:24584053) RGD PMID:24584053 MGI:5577209 NCBI chr20:4,576,033...4,592,980
Ensembl chr20:4,576,057...4,592,980
JBrowse link
G Slc1a1 solute carrier family 1 member 1 ISO (MGI:6492416|PMID:27208619) RGD PMID:27208619 MGI:6492416 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc1a2 solute carrier family 1 member 2 ISO (MGI:6492416|PMID:27208619) RGD PMID:27208619 MGI:6492416 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc1a3 solute carrier family 1 member 3 ISO (MGI:6492416|PMID:27208619) RGD PMID:27208619 MGI:6492416 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
cellular response to isoquinoline alkaloid term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr1 early growth response 1 IEP berberine RGD PMID:16448624 RGD:5131909 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Mecp2 methyl CpG binding protein 2 IDA bicuculline RGD PMID:22262897 RGD:12790719 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
cellular response to morphine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy8 adenylate cyclase 8 ISS
ISO
IDA
IEA
GO_REF:0000024
(MGI:3808962|PMID:18222416)
PMID:16186630
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:18222416, PMID:16186630 GO_REF:0000024 GO_REF:0000107 MGI:3808962, RGD:13825193 NCBI chr 7:105,353,883...105,593,372
Ensembl chr 7:105,353,913...105,592,804
JBrowse link
G Aif1 allograft inflammatory factor 1 IEP morphine RGD PMID:19176808 RGD:2313012 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Atg7 autophagy related 7 IEP RGD PMID:23800874 RGD:11557986 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP RGD PMID:20578038 RGD:4889899 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 IEP RGD PMID:18178009 RGD:6483056 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Oprm1 opioid receptor, mu 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B ISS
ISO
GO_REF:0000024
(MGI:3834288|PMID:18439408)
UniProt
RGD
PMID:18439408 GO_REF:0000024 MGI:3834288 NCBI chr10:82,800,704...82,816,735
Ensembl chr10:82,800,704...82,816,731
JBrowse link
G RT1-Bb RT1 class II, locus Bb IEP RGD PMID:14742686 RGD:7488923 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
cellular response to staurosporine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 ISO (PMID:22253444) RGD PMID:22253444 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 ISO (PMID:22253444) RGD PMID:22253444 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 ISO (PMID:22253444) RGD PMID:22253444 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Plau plasminogen activator, urokinase IEP RGD PMID:19137075 RGD:7241807 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Slc34a1 solute carrier family 34 member 1 IEP RGD PMID:10332085 RGD:7243183 NCBI chr17:9,747,766...9,762,739
Ensembl chr17:9,747,752...9,762,813
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20045
    response to stimulus 10557
      response to endogenous stimulus 2036
        cellular response to endogenous stimulus 1626
          cellular response to organonitrogen compound 853
            cellular response to alkaloid 49
              cellular response to caffeine + 12
              cellular response to camptothecin 5
              cellular response to cocaine 7
              cellular response to isoquinoline alkaloid + 10
              cellular response to staurosporine 5
              cellular response to tropane 0
Path 2
Term Annotations click to browse term
  biological_process 20045
    response to stimulus 10557
      response to chemical 6329
        response to organic substance 3874
          response to organonitrogen compound 1461
            response to alkaloid 186
              cellular response to alkaloid 49
                cellular response to caffeine + 12
                cellular response to camptothecin 5
                cellular response to cocaine 7
                cellular response to isoquinoline alkaloid + 10
                cellular response to staurosporine 5
                cellular response to tropane 0
paths to the root