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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular response to misfolded protein
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Accession:GO:0071218 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.


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cellular response to misfolded protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713 		JBrowse link
G Atxn3 ataxin 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5318000|PMID:21855799)		 UniProt
RGD		 PMID:21855799 GO_REF:0000024 MGI:5318000 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 involved_in ISO
IBA		 (PMID:21148293), (PMID:21150129)
PMID:21873635		 RGD PMID:21148293 PMID:21150129 PMID:21873635 RGD:13792537 NCBI chr20:27,828,216...27,846,428
Ensembl chr20:27,828,235...27,846,427 		JBrowse link
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490 		JBrowse link
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:27,269,345...27,303,471
Ensembl chr18:27,269,355...27,298,344 		JBrowse link
G Hdac6 histone deacetylase 6 acts_upstream_of_or_within ISO MGI:3776868 (MGI:3757892|PMID:17785525) RGD PMID:17785525 MGI:3757892 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 acts_upstream_of_or_within IDA PMID:23444373 MGI PMID:23444373 RGD:8554667 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IBA
ISO		 PMID:21873635
(MGI:5318000|PMID:21855799)
(PMID:16831871)		 RGD PMID:16831871 PMID:21855799 PMID:21873635 MGI:5318000, RGD:13792537 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W involved_in ISS
ISO		 GO_REF:0000024
(MGI:5318000|PMID:21855799)		 UniProt
RGD		 PMID:21855799 GO_REF:0000024 MGI:5318000 NCBI chr 5:2,690,742...2,754,491 JBrowse link
cytoplasm protein quality control by the ubiquitin-proteasome system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf126 ring finger protein 126 involved_in ISO (PMID:24981174) RGD PMID:24981174 NCBI chr 7:9,939,359...9,946,963
Ensembl chr 7:9,938,229...9,946,738 		JBrowse link
ER-associated misfolded protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor involved_in ISO
ISS		 (PMID:21857022)
GO_REF:0000024		 RGD
UniProt		 PMID:21857022 GO_REF:0000024 NCBI chr 4:115,560,274...115,563,346
Ensembl chr 4:115,560,261...115,563,346 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in ISO
ISS		 (PMID:23129660), (PMID:24981174)
GO_REF:0000024		 RGD
UniProt		 PMID:23129660 PMID:24981174 GO_REF:0000024 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Derl1 derlin 1 involved_in ISO (PMID:24089527) RGD PMID:24089527 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Ngly1 N-glycanase 1 IMP RGD PMID:32259258 RGD:39457703 NCBI chr15:9,153,738...9,210,228
Ensembl chr15:9,153,738...9,204,630 		JBrowse link
G Rnf185 ring finger protein 185 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:78,292,517...78,329,832
Ensembl chr14:78,292,516...78,329,864 		JBrowse link
G Rnf5 ring finger protein 5 involved_in ISO
IBA		 (PMID:19269966)
PMID:21873635		 RGD PMID:19269966 PMID:21873635 RGD:13792537 NCBI chr20:4,145,539...4,147,985
Ensembl chr20:4,145,507...4,147,985 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 acts_upstream_of_or_within IMP PMID:23444373 MGI PMID:23444373 RGD:8554667 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Tor1a torsin family 1, member A involved_in ISS
ISO		 GO_REF:0000024
(MGI:3712415|PMID:17200151)		 UniProt
RGD		 PMID:17200151 GO_REF:0000024 MGI:3712415 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in IBA
ISO		 PMID:21873635
(PMID:24089527)		 RGD PMID:24089527 PMID:21873635 RGD:13792537 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087 		JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:38,355,229...38,468,473
Ensembl chr 9:38,359,089...38,468,467 		JBrowse link
G Vcp valosin-containing protein involved_in IBA
ISO		 PMID:21873635
(PMID:24089527)		 RGD PMID:24089527 PMID:21873635 RGD:13792537 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
nuclear protein quality control by the ubiquitin-proteasome system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cul3 cullin 3 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:27561354)		 UniProt
Ensembl
RGD		 PMID:27561354 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Klhl15 kelch-like family member 15 involved_in ISO
ISS		 (PMID:27561354)
GO_REF:0000024		 RGD
UniProt		 PMID:27561354 GO_REF:0000024 NCBI chr  X:58,994,726...59,050,207
Ensembl chr  X:58,995,461...59,046,069 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19504
    response to stimulus 10363
      response to stress 4035
        response to topologically incorrect protein 142
          response to misfolded protein 24
            cellular response to misfolded protein 22
              ER-associated misfolded protein catabolic process 11
              cytoplasm protein quality control by the ubiquitin-proteasome system 1
              nuclear protein quality control by the ubiquitin-proteasome system + 2
Path 2
Term Annotations click to browse term
  biological_process 19504
    response to stimulus 10363
      response to chemical 6194
        response to organic substance 3899
          cellular response to organic substance 2872
            cellular response to topologically incorrect protein 119
              cellular response to misfolded protein 22
                ER-associated misfolded protein catabolic process 11
                cytoplasm protein quality control by the ubiquitin-proteasome system 1
                nuclear protein quality control by the ubiquitin-proteasome system + 2
paths to the root