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ONTOLOGY REPORT - ANNOTATIONS

Term:RNA cap trimethylguanosine synthase activity
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Accession:GO:0071164 term browser browse the term
Definition:Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine.
Comment:A 2,2,7-trimethylguanosine (TMG) cap is found on many RNA polymerase II transcribed small noncoding RNAs including small nuclear RNA (snRNA), small nucleolar RNA (snoRNA) and telomerase RNA. It is also found on nematode mRNAs that undergo trans-splicing of a 5'-capped leader sequence.
Synonyms:exact_synonym: RNA trimethylguanosine synthase activity;   cap hypermethylase activity
 related_synonym: small nuclear RNA methyltransferase activity;   snRNA methyltransferase activity


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RNA cap trimethylguanosine synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgs1 trimethylguanosine synthase 1 enables ISO
IBA		 (PMID:16687569)
GO_REF:0000033		 RGD
GO_Central		 PMID:16687569 GO_REF:0000033 NCBI chr 5:16,524,864...16,558,399
Ensembl chr 5:16,524,874...16,558,399 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21086
    catalytic activity 6121
      catalytic activity, acting on a nucleic acid 630
        catalytic activity, acting on RNA 389
          RNA methyltransferase activity 63
            RNA cap trimethylguanosine synthase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 21086
    catalytic activity 6121
      transferase activity 2441
        transferase activity, transferring one-carbon groups 214
          methyltransferase activity 203
            RNA methyltransferase activity 63
              RNA cap trimethylguanosine synthase activity 1
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