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ONTOLOGY REPORT - ANNOTATIONS


Term:NF-kappaB complex
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Accession:GO:0071159 term browser browse the term
Definition:A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression.


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NF-kappaB complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rps3 ribosomal protein S3 ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:164,435,868...164,441,167
Ensembl chr 1:164,435,878...164,441,167
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NF-kappaB p50/p65 complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rela RELA proto-oncogene, NF-kB subunit ISO (PMID:18045535) RGD PMID:18045535 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6092
      NF-kappaB complex 2
        NF-kappaB p50/p65 complex 1
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      intracellular anatomical structure 14706
        NF-kappaB complex 2
          NF-kappaB p50/p65 complex 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.