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ONTOLOGY REPORT - ANNOTATIONS

Term:heteromeric SMAD protein complex
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Accession:GO:0071144 term browser browse the term
Definition:A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.
Synonyms:narrow_synonym: SMAD1-SMAD4 protein complex;   SMAD2-SMAD3-SMAD4 protein complex;   SMAD2-SMAD4 protein complex;   SMAD3-SMAD4 protein complex
 alt_id: GO:0071145;   GO:0071146


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heteromeric SMAD protein complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad1 SMAD family member 1 part_of IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:11779505)		 Ensembl
GO_Central
RGD		 PMID:11779505 GO_REF:0000033 GO_REF:0000107 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad2 SMAD family member 2 part_of IBA
ISO		 GO_REF:0000033
(PMID:15350224), (PMID:21828274)		 GO_Central
RGD		 PMID:15350224 PMID:21828274 GO_REF:0000033 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 part_of ISO
IBA		 (PMID:21828274)
GO_REF:0000033		 RGD
GO_Central		 PMID:21828274 GO_REF:0000033 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad4 SMAD family member 4 part_of IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:11779505), (PMID:15350224)		 Ensembl
GO_Central
RGD		 PMID:11779505 PMID:15350224 GO_REF:0000033 GO_REF:0000107 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smad5 SMAD family member 5 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634 		JBrowse link
G Smad6 SMAD family member 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763 		JBrowse link
G Smad7 SMAD family member 7 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Smad9 SMAD family member 9 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20814
    protein-containing complex 6438
      SMAD protein complex 10
        heteromeric SMAD protein complex 8
Path 2
Term Annotations click to browse term
  cellular_component 20814
    cellular anatomical structure 20574
      organelle 14007
        membrane-bounded organelle 12605
          intracellular membrane-bounded organelle 12057
            nucleus 7485
              nuclear protein-containing complex 1306
                RNA polymerase II transcription regulator complex 244
                  heteromeric SMAD protein complex 8
paths to the root