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ONTOLOGY REPORT - ANNOTATIONS

Term:U2-type catalytic step 1 spliceosome
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Accession:GO:0071006 term browser browse the term
Definition:A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs.
Synonyms:exact_synonym: U2-type activated spliceosome;   major catalytic step 1 spliceosome
 narrow_synonym: GT-AG catalytic step 1 spliceosome;   mammalian U2-type spliceosomal complex B*;   mammalian U2-type spliceosomal complex B2;   yeast U2-type spliceosomal complex A1


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U2-type catalytic step 1 spliceosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASC3 CASC3 exon junction complex subunit part_of IEA Ensembl GO_REF:0000107 NCBI chr17:17,116,864...17,148,752
Ensembl chr17:17,339,060...17,370,076 		JBrowse link
G CWC22 CWC22 spliceosome associated protein homolog part_of IEA Ensembl GO_REF:0000107 NCBI chr2B:67,198,535...67,261,588
Ensembl chr2B:184,901,960...184,945,273 		JBrowse link
G CWC25 CWC25 spliceosome associated protein homolog part_of IEA Ensembl GO_REF:0000107 NCBI chr17:18,446,107...18,471,059
Ensembl chr17:18,719,907...18,745,213 		JBrowse link
G ISY1 ISY1 splicing factor homolog part_of IEA Ensembl GO_REF:0000107 NCBI chr 3:126,187,354...126,219,355
Ensembl chr 3:133,545,726...133,575,974 		JBrowse link
G LOC100988043 eukaryotic initiation factor 4A-III part_of ISO (PMID:29301961) UniProt PMID:29301961 NCBI chr17:74,221,793...74,233,738 JBrowse link
G MAGOH mago homolog, exon junction complex subunit part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:52,499,829...52,511,710
Ensembl chr 1:54,099,198...54,111,142 		JBrowse link
G MAGOHB mago homolog B, exon junction complex subunit part_of IEA Ensembl GO_REF:0000107 NCBI chr12:10,632,174...10,639,758
Ensembl chr12:10,898,716...10,905,958 		JBrowse link
G PRPF19 pre-mRNA processing factor 19 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr11:56,153,965...56,169,821
Ensembl chr11:59,595,120...59,607,828 		JBrowse link
G PRPF8 pre-mRNA processing factor 8 part_of IEA Ensembl GO_REF:0000107 NCBI chr17:1,635,991...1,669,703
Ensembl chr17:1,532,579...1,565,254 		JBrowse link
G RBM22 RNA binding motif protein 22 part_of IEA TreeGrafter GO_REF:0000118 NCBI chr 5:146,115,077...146,125,383
Ensembl chr 5:152,118,945...152,129,261 		JBrowse link
G RBM8A RNA binding motif protein 8A part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:121,830,424...121,836,378
Ensembl chr 1:113,834,110...113,839,429 		JBrowse link
G SNRNP200 small nuclear ribonucleoprotein U5 subunit 200 part_of IEA Ensembl GO_REF:0000107 NCBI chr2A:103,010,083...103,040,958
Ensembl chr2A:97,197,137...97,228,511 		JBrowse link
G YJU2 YJU2 splicing factor homolog part_of IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr19:3,270,432...3,292,457
Ensembl chr19:4,217,457...4,239,684 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17403
    protein-containing complex 5759
      catalytic complex 1703
        catalytic step 1 spliceosome 13
          U2-type catalytic step 1 spliceosome 13
Path 2
Term Annotations click to browse term
  cellular_component 17403
    cellular anatomical entity 17180
      organelle 12682
        membrane-bounded organelle 11557
          intracellular membrane-bounded organelle 11021
            nucleus 6835
              nuclear protein-containing complex 1237
                spliceosomal complex 207
                  U2-type spliceosomal complex 100
                    U2-type catalytic step 1 spliceosome 13
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