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ONTOLOGY REPORT - ANNOTATIONS

Term:U2-type catalytic step 1 spliceosome
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Accession:GO:0071006 term browser browse the term
Definition:A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs.
Synonyms:exact_synonym: U2-type activated spliceosome;   major catalytic step 1 spliceosome
 narrow_synonym: GT-AG catalytic step 1 spliceosome;   mammalian U2-type spliceosomal complex B*;   mammalian U2-type spliceosomal complex B2;   yeast U2-type spliceosomal complex A1


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U2-type catalytic step 1 spliceosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casc3 CASC3 exon junction complex subunit part_of ISS
ISO
IEA		 GO_REF:0000024
(PMID:29301961)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:29301961 GO_REF:0000024 GO_REF:0000107 NCBI chr10:83,769,014...83,788,966
Ensembl chr10:83,769,001...83,788,966 		JBrowse link
G Cwc22 CWC22 spliceosome associated protein part_of ISO (PMID:29301961) RGD PMID:29301961 NCBI chr 3:62,815,230...62,864,269
Ensembl chr 3:62,802,045...62,864,228 		JBrowse link
G Cwc25 CWC25 spliceosome-associated protein homolog part_of ISO (PMID:29301961) RGD PMID:29301961 NCBI chr10:82,735,698...82,760,373
Ensembl chr10:82,736,995...82,760,354 		JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 part_of ISO
ISS		 (PMID:29301961)
GO_REF:0000024		 RGD
UniProt		 PMID:29301961 GO_REF:0000024 NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057 		JBrowse link
G Isy1 ISY1 splicing factor homolog part_of ISS
ISO		 GO_REF:0000024
(PMID:29301961)		 UniProt
RGD		 PMID:29301961 GO_REF:0000024 NCBI chr 4:120,276,535...120,297,227
Ensembl chr 4:120,276,292...120,297,188 		JBrowse link
G LOC134482366 splicing factor YJU2-like part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Magohb mago homolog B, exon junction complex subunit part_of ISO (PMID:29301961) RGD PMID:29301961 NCBI chr 4:165,034,131...165,041,977
Ensembl chr 4:165,034,122...165,041,967 		JBrowse link
G Prpf19 pre-mRNA processing factor 19 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662 		JBrowse link
G Prpf8 pre-mRNA processing factor 8 part_of ISO (PMID:29301961) RGD PMID:29301961 NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,331,494...60,354,606 		JBrowse link
G Rbm22 RNA binding motif protein 22 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:54,013,374...54,024,182
Ensembl chr18:54,013,351...54,024,569 		JBrowse link
G Rbm8a RNA binding motif protein 8A part_of ISS
ISO		 GO_REF:0000024
(PMID:29301961)		 UniProt
RGD		 PMID:29301961 GO_REF:0000024 NCBI chr 2:184,165,189...184,167,959
Ensembl chr 2:184,165,193...184,167,959 		JBrowse link
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 part_of ISS
ISO
IEA		 GO_REF:0000024
(PMID:29301961)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:29301961 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182 		JBrowse link
G Yju2 YJU2 splicing factor part_of ISO
IBA		 (PMID:29301961)
GO_REF:0000033		 RGD
GO_Central		 PMID:29301961 GO_REF:0000033 NCBI chr 9:789,603...799,505
Ensembl chr 9:789,606...799,496 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20817
    protein-containing complex 6437
      catalytic complex 1837
        catalytic step 1 spliceosome 13
          U2-type catalytic step 1 spliceosome 13
Path 2
Term Annotations click to browse term
  cellular_component 20817
    cellular anatomical entity 20577
      organelle 14007
        membrane-bounded organelle 12604
          intracellular membrane-bounded organelle 12056
            nucleus 7484
              nuclear protein-containing complex 1305
                spliceosomal complex 222
                  U2-type spliceosomal complex 100
                    U2-type catalytic step 1 spliceosome 13
paths to the root