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ONTOLOGY REPORT - ANNOTATIONS

Term:U2-type precatalytic spliceosome
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Accession:GO:0071005 term browser browse the term
Definition:A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
Synonyms:exact_synonym: major precatalytic spliceosome
 narrow_synonym: GT-AG precatalytic spliceosome;   mammalian U2-type spliceosomal complex B;   mammalian U2-type spliceosomal complex B1
 related_synonym: yeast U12-type spliceosomal complex A2-1


show annotations for term's descendants           Sort by:
U2-type precatalytic spliceosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bud13 BUD13 homolog part_of IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:29360106)		 Ensembl
UniProt
RGD		 PMID:29360106 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:46,575,124...46,590,964
Ensembl chr 8:46,575,115...46,590,958 		JBrowse link
G Cwc22 CWC22 spliceosome associated protein part_of ISO (PMID:29360106) RGD PMID:29360106 NCBI chr 3:62,815,230...62,864,269
Ensembl chr 3:62,802,045...62,864,228 		JBrowse link
G Cwc27 CWC27 spliceosome associated cyclophilin part_of ISO
ISS
IEA		 (PMID:29360106)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:29360106 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:35,764,674...35,975,908
Ensembl chr 2:35,764,686...35,975,872 		JBrowse link
G Dhx16 DEAH-box helicase 16 part_of ISO (PMID:29360106) RGD PMID:29360106 NCBI chr20:2,862,000...2,874,991
Ensembl chr20:2,862,000...2,874,948 		JBrowse link
G Eftud2 elongation factor Tu GTP binding domain containing 2 part_of ISO (PMID:29361316) RGD PMID:29361316 NCBI chr10:87,804,893...87,852,181
Ensembl chr10:87,804,892...87,846,079 		JBrowse link
G Ik IK cytokine part_of ISS
ISO		 GO_REF:0000024
(PMID:28781166)		 UniProt
RGD		 PMID:28781166 GO_REF:0000024 NCBI chr18:28,358,004...28,372,809
Ensembl chr18:28,357,977...28,378,832 		JBrowse link
G Linc00176 long intergenic non-protein coding RNA 176 part_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 3:168,771,350...168,775,133
Ensembl chr 3:168,704,299...168,774,991 		JBrowse link
G Lsm2 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr20:3,843,467...3,847,217
Ensembl chr20:3,843,466...3,847,266 		JBrowse link
G Lsm3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 4:124,021,023...124,027,269
Ensembl chr 4:124,021,023...124,027,269 		JBrowse link
G Lsm4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr16:18,755,481...18,761,106
Ensembl chr16:18,755,484...18,760,926 		JBrowse link
G Lsm5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165 		JBrowse link
G Lsm6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr19:29,098,254...29,112,858
Ensembl chr13:42,114,032...42,116,484
Ensembl chr19:42,114,032...42,116,484 		JBrowse link
G Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 7:8,856,698...8,859,113
Ensembl chr 7:8,856,489...8,859,119 		JBrowse link
G Lsm8 LSM8 homolog, U6 small nuclear RNA associated part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 4:47,306,259...47,312,125
Ensembl chr 4:47,306,295...47,314,293 		JBrowse link
G Magohb mago homolog B, exon junction complex subunit part_of ISO (PMID:28502770) RGD PMID:28502770 NCBI chr 4:165,034,131...165,041,977
Ensembl chr 4:165,034,122...165,041,967 		JBrowse link
G Mfap1a microfibrillar-associated protein 1A part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 3:108,440,163...108,456,744
Ensembl chr 3:108,438,845...108,456,750 		JBrowse link
G Phf5a PHD finger protein 5A part_of ISO (PMID:29360106) RGD PMID:29360106 NCBI chr 7:113,378,469...113,385,035
Ensembl chr 7:113,378,471...113,385,460 		JBrowse link
G Prpf3 pre-mRNA processing factor 3 part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 2:183,379,041...183,403,526
Ensembl chr 2:183,378,718...183,403,489 		JBrowse link
G Prpf31 pre-mRNA processing factor 31 part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 1:65,575,887...65,587,561
Ensembl chr 1:65,575,887...65,587,873 		JBrowse link
G Prpf38a pre-mRNA processing factor 38A part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 5:123,312,461...123,324,160
Ensembl chr 5:123,311,482...123,323,972 		JBrowse link
G Prpf4 pre-mRNA splicing tri-snRNP complex factor 4 part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 5:75,859,934...75,873,924
Ensembl chr 5:75,859,924...75,873,919 		JBrowse link
G Prpf6 pre-mRNA processing factor 6 part_of ISS
ISO
IEA		 GO_REF:0000024
(PMID:28781166)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28781166 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991 		JBrowse link
G Prpf8 pre-mRNA processing factor 8 part_of ISO (PMID:28781166), (PMID:29361316), (PMID:30315277) RGD PMID:28781166 PMID:29361316 PMID:30315277 NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,331,494...60,354,606 		JBrowse link
G Rbmx2 RNA binding motif protein, X-linked 2 part_of ISO
ISS		 (PMID:29360106)
GO_REF:0000024		 RGD
UniProt		 PMID:29360106 GO_REF:0000024 NCBI chr  X:127,888,514...127,896,239
Ensembl chr  X:127,888,438...127,896,869 		JBrowse link
G Rnf113a1 ring finger protein 113A1 part_of ISO (PMID:29360106) RGD PMID:29360106 NCBI chr  X:116,427,941...116,429,164
Ensembl chr  X:116,427,684...116,433,762 		JBrowse link
G Sart1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 1:202,690,472...202,699,136
Ensembl chr 1:202,690,459...202,699,136 		JBrowse link
G Sf3a1 splicing factor 3A subunit 1 part_of ISO (PMID:10882114), (PMID:29360106) RGD PMID:10882114 PMID:29360106 NCBI chr14:79,031,394...79,052,144
Ensembl chr14:79,031,394...79,052,144 		JBrowse link
G Sf3a2 splicing factor 3A subunit 2 part_of ISS
ISO		 GO_REF:0000024
(PMID:29360106)		 UniProt
RGD		 PMID:29360106 GO_REF:0000024 NCBI chr 7:8,909,507...8,916,104
Ensembl chr 7:8,909,507...8,915,530 		JBrowse link
G Sf3a3 splicing factor 3a, subunit 3 part_of ISO (PMID:29360106), (PMID:8022796) RGD PMID:8022796 PMID:29360106 NCBI chr 5:136,967,713...136,987,345
Ensembl chr 5:136,967,691...136,987,361 		JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 part_of ISO (PMID:28781166), (PMID:29360106) RGD PMID:28781166 PMID:29360106 NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300 		JBrowse link
G Sf3b2 splicing factor 3b, subunit 2 part_of ISO (PMID:29360106) RGD PMID:29360106 NCBI chr 1:202,570,423...202,590,774
Ensembl chr 1:202,570,423...202,590,759 		JBrowse link
G Sf3b3 splicing factor 3b, subunit 3 part_of ISO (PMID:28781166), (PMID:29360106) RGD PMID:28781166 PMID:29360106 NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245 		JBrowse link
G Sf3b4 splicing factor 3B subunit 4 part_of ISO
IEA		 (PMID:29360106)
GO_REF:0000107		 RGD
Ensembl		 PMID:29360106 GO_REF:0000107 NCBI chr 2:183,732,791...183,737,545
Ensembl chr 2:183,732,754...183,737,959 		JBrowse link
G Sf3b5 splicing factor 3b, subunit 5 part_of ISO (PMID:28781166), (PMID:29360106) RGD PMID:28781166 PMID:29360106 NCBI chr 1:7,357,040...7,357,752
Ensembl chr 1:7,350,731...7,357,839 		JBrowse link
G Smu1 SMU1, DNA replication regulator and spliceosomal factor part_of IEA
ISO
ISS		 GO_REF:0000107
(PMID:28781166)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:28781166 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:55,856,691...55,875,262
Ensembl chr 5:55,856,246...55,875,300 		JBrowse link
G Snip1 Smad nuclear interacting protein 1 part_of ISS
ISO		 GO_REF:0000024
(PMID:29360106)		 UniProt
RGD		 PMID:29360106 GO_REF:0000024 NCBI chr 5:137,328,371...137,335,846
Ensembl chr 5:137,328,371...137,335,845 		JBrowse link
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 part_of ISS
ISO
IEA		 GO_REF:0000024
(PMID:29361316)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:29361316 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182 		JBrowse link
G Snrpa1 small nuclear ribonucleoprotein polypeptide A' part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 1:119,641,402...119,654,653
Ensembl chr 1:119,638,481...119,654,653 		JBrowse link
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 part_of ISS
ISO		 GO_REF:0000024
(PMID:28781166)		 UniProt
RGD		 PMID:28781166 GO_REF:0000024 NCBI chr 3:117,369,816...117,379,344
Ensembl chr 3:117,370,100...117,379,339 		JBrowse link
G Snrpb2 small nuclear ribonucleoprotein polypeptide B2 part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 3:130,399,239...130,408,821
Ensembl chr 3:130,399,248...130,408,812 		JBrowse link
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr18:1,696,838...1,707,400
Ensembl chr18:1,696,852...1,708,256 		JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351 		JBrowse link
G Snrpd3 small nuclear ribonucleoprotein D3 polypeptide part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr20:13,130,112...13,145,947
Ensembl chr20:13,130,119...13,145,978 		JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310
Ensembl chr 8:45,050,986...45,057,310 		JBrowse link
G Snrpf small nuclear ribonucleoprotein polypeptide F part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 7:28,130,427...28,137,129
Ensembl chr 7:28,130,427...28,137,129 		JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr 4:118,812,278...118,819,827
Ensembl chr 4:118,812,252...118,819,826 		JBrowse link
G Snu13 small nuclear ribonucleoprotein 13 part_of ISO
ISS		 (PMID:28781166)
GO_REF:0000024		 RGD
UniProt		 PMID:28781166 GO_REF:0000024 NCBI chr 7:113,565,293...113,570,887
Ensembl chr 7:113,565,295...113,570,872
Ensembl chr 1:113,565,295...113,570,872 		JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 part_of ISO (PMID:29361316) RGD PMID:29361316 NCBI chr10:12,815,471...12,848,750
Ensembl chr10:12,815,471...12,848,751 		JBrowse link
G Txnl4a thioredoxin-like 4A part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr18:73,659,107...73,674,893
Ensembl chr18:73,659,107...73,674,893 		JBrowse link
G Wbp4 WW domain binding protein 4 part_of ISS
ISO
IEA		 GO_REF:0000024
(PMID:28781166)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28781166 GO_REF:0000024 GO_REF:0000107 NCBI chr15:54,862,700...54,890,668
Ensembl chr15:54,862,843...54,890,647 		JBrowse link
G Zmat2 zinc finger, matrin type 2 part_of ISO (PMID:28781166) RGD PMID:28781166 NCBI chr18:28,409,606...28,414,241
Ensembl chr18:28,398,795...28,414,747 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20817
    protein-containing complex 6437
      ribonucleoprotein complex 1245
        spliceosomal complex 222
          U2-type spliceosomal complex 100
            U2-type precatalytic spliceosome 51
Path 2
Term Annotations click to browse term
  cellular_component 20817
    cellular anatomical entity 20577
      organelle 14007
        intracellular organelle 13599
          intracellular membrane-bounded organelle 12056
            nucleus 7484
              nuclear protein-containing complex 1305
                spliceosomal complex 222
                  U2-type spliceosomal complex 100
                    U2-type precatalytic spliceosome 51
paths to the root