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ONTOLOGY REPORT - ANNOTATIONS


Term:protein K48-linked ubiquitination
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Accession:GO:0070936 term browser browse the term
Definition:A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
Synonyms:exact_synonym: protein K48-linked polyubiquitination


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protein K48-linked ubiquitination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:1624291
RGD:13792537
G Arih2 ariadne RBR E3 ubiquitin protein ligase 2 JBrowse link 8 117,387,004 117,446,085 RGD:1624291
G Bfar bifunctional apoptosis regulator JBrowse link 10
10
1,464,658
1,464,783
1,471,152
1,497,653
RGD:1624291
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:1624291
G Cdc34 cell division cycle 34 JBrowse link 7 12,899,957 12,905,339 RGD:1624291
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:1624291
G Dtx3l deltex E3 ubiquitin ligase 3L JBrowse link 11
11
67,758,093
67,768,542
67,767,623
67,772,428
RGD:1624291
G Fbxo38 F-box protein 38 JBrowse link 18 57,827,391 57,874,515 RGD:1624291
G Hace1 HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 JBrowse link 20 50,652,489 50,783,937 RGD:1624291
RGD:1600115
G Ifi27 interferon, alpha-inducible protein 27 JBrowse link 6 127,327,959 127,334,430 RGD:1624291
G Itch itchy E3 ubiquitin protein ligase JBrowse link 3 150,660,665 150,752,016 RGD:1624291
RGD:13792537
G Klhl3 kelch-like family member 3 JBrowse link 17 6,924,423 7,029,374 RGD:1624291
RGD:1600115
RGD:13792537
G Marchf6 membrane associated ring-CH-type finger 6 JBrowse link 2 84,533,546 84,608,743 RGD:1624291
G Nedd4l NEDD4 like E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:1624291
G Nhlrc4 NHL repeat containing 4 JBrowse link 10 15,305,723 15,306,534 RGD:13792537
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link 14 106,008,086 106,062,566 RGD:1624291
RGD:13792537
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1600115
RGD:1624291
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:1624291
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase JBrowse link 10 70,157,621 70,220,618 RGD:1600115
RGD:1624291
G Rnf115 ring finger protein 115 JBrowse link 2 198,852,392 198,920,000 RGD:1624291
G Rnf126 ring finger protein 126 JBrowse link 7 12,820,796 12,828,325 RGD:1624291
G Rnf146 ring finger protein 146 JBrowse link 1 30,856,923 30,873,814 RGD:1600115
RGD:1624291
G Rnf152 ring finger protein 152 JBrowse link 13 25,183,295 25,262,785 RGD:1624291
RGD:13792537
RGD:1600115
G Rnf187 ring finger protein 187 JBrowse link 10 45,273,400 45,279,299 RGD:1624291
RGD:1600115
G Rnf216 ring finger protein 216 JBrowse link 12 13,508,429 13,631,689 RGD:1624291
G Rnf34 ring finger protein 34 JBrowse link 12 39,164,290 39,185,209 RGD:1624291
RGD:1600115
G Rnf4 ring finger protein 4 JBrowse link 14 81,658,400 81,679,756 RGD:8553731
G Rnf5 ring finger protein 5 JBrowse link 20 4,366,244 4,368,690 RGD:1624291
G Rnf6 ring finger protein 6 JBrowse link 12 10,574,168 10,583,196 RGD:1624291
G Rnf8 ring finger protein 8 JBrowse link 20 8,285,380 8,309,858 RGD:1600115
RGD:13792537
RGD:1624291
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:1624291
G Skp2 S-phase kinase associated protein 2 JBrowse link 2 58,506,146 58,534,211 RGD:1624291
G Syvn1 synoviolin 1 JBrowse link 1 221,409,281 221,416,229 RGD:1624291
RGD:13792537
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
G Topors TOP1 binding arginine/serine rich protein JBrowse link 5 56,554,956 56,566,503 RGD:1624291
G Trim38 tripartite motif containing 38 JBrowse link 17 43,600,006 43,607,879 RGD:1624291
G Ttc3 tetratricopeptide repeat domain 3 JBrowse link 11 34,598,324 34,739,986 RGD:1624291
G Ube2a ubiquitin-conjugating enzyme E2A JBrowse link X 123,486,988 123,497,726 RGD:1624291
G Ube2b ubiquitin-conjugating enzyme E2B JBrowse link 10 37,439,947 37,454,867 RGD:1624291
RGD:1600115
G Ube2c ubiquitin-conjugating enzyme E2C JBrowse link 3 161,236,971 161,239,371 RGD:1624291
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 JBrowse link 20 18,547,370 18,580,291 RGD:1624291
RGD:13792537
RGD:1600115
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 JBrowse link 18 28,561,957 28,603,335 RGD:1624291
RGD:1600115
RGD:13792537
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 JBrowse link 2 240,626,198 240,655,874 RGD:1624291
RGD:1600115
G Ube2d4 ubiquitin-conjugating enzyme E2D 4 (putative) JBrowse link 14 2,933,097 2,934,571 RGD:1624291
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 JBrowse link 15 8,124,869 8,178,252 RGD:1624291
RGD:13792537
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 JBrowse link 15 7,402,210 7,928,320 RGD:1624291
RGD:1600115
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 JBrowse link 3 65,815,076 65,876,256 RGD:1624291
RGD:13792537
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 JBrowse link 10 59,173,268 59,254,458 RGD:1624291
RGD:1600115
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 JBrowse link 20 11,700,089 11,721,823 RGD:1624291
G Ube2h ubiquitin-conjugating enzyme E2H JBrowse link 4 57,511,418 57,625,147 RGD:1624291
G Ube2k ubiquitin-conjugating enzyme E2K JBrowse link 14 44,289,247 44,348,691 RGD:1624291
G Ube2q2 ubiquitin conjugating enzyme E2 Q2 JBrowse link 8 59,709,972 59,754,102 RGD:1624291
RGD:1600115
G Ube2q2l ubiquitin-conjugating enzyme E2Q family member 2-like JBrowse link X 10,771,112 10,772,633 RGD:13792537
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 JBrowse link 5 57,472,315 57,530,973 RGD:1624291
G Ube2t ubiquitin-conjugating enzyme E2T JBrowse link 13 51,790,877 51,801,379 RGD:1624291
G Ube3a ubiquitin protein ligase E3A JBrowse link 1 116,586,901 116,678,161 RGD:1624291
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 JBrowse link 7
7
76,789,110
76,839,661
76,835,517
76,907,441
RGD:1600115
RGD:1624291
G Znrf1 zinc and ring finger 1 JBrowse link 19 43,750,205 43,834,962 RGD:1624291
negative regulation of protein K48-linked ubiquitination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trim44 tripartite motif-containing 44 JBrowse link 3 91,968,781 92,242,138 RGD:1624291
RGD:1600115
positive regulation of protein K48-linked ubiquitination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:1624291
G Nmi N-myc (and STAT) interactor JBrowse link 3 37,458,891 37,480,984 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    metabolic process 11638
      cellular metabolic process 10639
        cellular macromolecule metabolic process 8177
          cellular protein metabolic process 5335
            cellular protein modification process 3849
              protein modification by small protein conjugation or removal 899
                protein modification by small protein conjugation 769
                  protein ubiquitination 720
                    protein polyubiquitination 220
                      protein K48-linked ubiquitination 61
                        negative regulation of protein K48-linked ubiquitination 1
                        positive regulation of protein K48-linked ubiquitination 2
                        regulation of protein K48-linked ubiquitination + 3
Path 2
Term Annotations click to browse term
  biological_process 19439
    metabolic process 11638
      organic substance metabolic process 11027
        macromolecule metabolic process 9491
          protein metabolic process 6016
            protein modification process 3849
              cellular protein modification process 3849
                protein modification by small protein conjugation or removal 899
                  protein modification by small protein conjugation 769
                    protein ubiquitination 720
                      protein polyubiquitination 220
                        protein K48-linked ubiquitination 61
                          negative regulation of protein K48-linked ubiquitination 1
                          positive regulation of protein K48-linked ubiquitination 2
                          regulation of protein K48-linked ubiquitination + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.