Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:RISC complex assembly
go back to main search page
Accession:GO:0070922 term browser browse the term
Definition:The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing completent complex that mediates gene silencing by small RNA.
Synonyms:narrow_synonym: miRNA loading onto RISC;   siRNA loading onto RISC involved in RNA interference;   siRNA loading onto RISC involved in gene silencing by small RNA
 broad_synonym: miRISC assembly
 related_synonym: RISC assembly;   gene silencing by RNA, small RNA loading onto RISC;   small RNA loading onto RISC
 alt_id: GO:0035087;   GO:0035280;   GO:0070923



show annotations for term's descendants           Sort by:
 
RISC complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific acts_upstream_of_or_within ISO (PMID:23622242) RGD PMID:23622242 NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282
JBrowse link
G Ago1 argonaute RISC component 1 involved_in ISO (PMID:19966796) RGD PMID:19966796 NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546
JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in ISO
IEA
(PMID:16271387), (PMID:18178619), (PMID:19966796), (PMID:23661684)
GO_REF:0000107
(PMID:19701182), (PMID:19966796)
RGD
Ensembl
PMID:16271387 PMID:18178619 PMID:19701182 PMID:19966796 PMID:23661684 GO_REF:0000107 NCBI chr 7:105,018,202...105,105,120
Ensembl chr 7:105,029,120...105,104,974
JBrowse link
G Ago3 argonaute RISC catalytic component 3 involved_in ISO (PMID:19966796) RGD PMID:19966796 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
JBrowse link
G Ago4 argonaute RISC component 4 involved_in ISO (PMID:19966796) RGD PMID:19966796 NCBI chr 5:138,780,450...138,825,889
Ensembl chr 5:138,783,069...138,825,632
JBrowse link
G Clp1 cleavage factor polyribonucleotide kinase subunit 1 involved_in ISO
ISS
(PMID:17495927)
GO_REF:0000024
RGD
UniProt
PMID:17495927 GO_REF:0000024 NCBI chr 3:69,806,774...69,818,633
Ensembl chr 3:69,806,778...69,810,421
JBrowse link
G Dhx9 DExH-box helicase 9 involved_in ISO (PMID:17531811) RGD PMID:17531811 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
JBrowse link
G Dicer1 dicer 1 ribonuclease III involved_in ISO (PMID:16271387), (PMID:18178619), (PMID:23661684)
(PMID:15973356), (PMID:18178619)
RGD PMID:15973356 PMID:16271387 PMID:18178619 PMID:23661684 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 involved_in ISO (PMID:23661684) RGD PMID:23661684 NCBI chr 3:61,575,447...61,594,393
Ensembl chr 3:61,575,447...61,594,347
JBrowse link
G Tarbp2 Tarbp2 subunit of RISC loading complex involved_in ISO (PMID:16271387), (PMID:18178619)
(PMID:15973356), (PMID:18178619)
RGD PMID:15973356 PMID:16271387 PMID:18178619 NCBI chr 7:133,649,118...133,654,306
Ensembl chr 7:133,649,090...133,654,314
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    negative regulation of biological process 5769
      negative regulation of metabolic process 3297
        negative regulation of macromolecule metabolic process 3065
          negative regulation of gene expression 1262
            gene silencing by RNA 311
              RISC complex assembly 10
Path 2
Term Annotations click to browse term
  biological_process 18734
    biological regulation 13314
      regulation of biological process 12594
        regulation of metabolic process 6750
          negative regulation of metabolic process 3297
            negative regulation of macromolecule metabolic process 3065
              negative regulation of gene expression 1262
                gene silencing by RNA 311
                  RISC complex assembly 10
paths to the root