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ONTOLOGY REPORT - ANNOTATIONS


Term:Sin3-type complex
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Accession:GO:0070822 term browser browse the term
Definition:Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.


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Sin3-type complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brms1 BRMS1, transcriptional repressor and anoikis regulator IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:220,325,352...220,334,616 JBrowse link
G Brms1l BRMS1 like transcriptional repressor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:76,675,399...76,708,261
NCBI chr 6:76,743,243...76,753,950
Ensembl chr 6:76,675,418...76,708,261
Ensembl chr 6:76,675,418...76,708,261
JBrowse link
G LOC108348098 breast cancer metastasis-suppressor 1 homolog IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:220,418,455...220,427,785
Ensembl chr 1:220,325,352...220,334,615
JBrowse link
G Phf12 PHD finger protein 12 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:64,815,462...64,863,514
Ensembl chr10:64,815,462...64,862,268
JBrowse link
G Sap130 Sin3A associated protein 130 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:24,397,523...24,497,831
Ensembl chr18:24,397,369...24,497,832
JBrowse link
G Suds3 SDS3 homolog, SIN3A corepressor complex component IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:45,199,012...45,221,507
Ensembl chr12:45,199,577...45,221,512
JBrowse link
Sin3 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07024825.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr16:18,447,078...18,456,158 JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 ISO (PMID:17827154) RGD PMID:17827154 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Hdac1 histone deacetylase 1 ISO (PMID:17827154) RGD PMID:17827154 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac2 histone deacetylase 2 ISO (PMID:14966270), (PMID:17827154) RGD PMID:14966270, PMID:17827154 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 colocalizes_with ISO (PMID:11486045) RGD PMID:11486045 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Ing2 inhibitor of growth family, member 2 ISO (PMID:16387653) RGD PMID:16387653 NCBI chr16:47,714,756...47,725,836
Ensembl chr16:47,717,951...47,725,836
JBrowse link
G Morf4l1 mortality factor 4 like 1 ISO
ISS
(PMID:14966270)
GO_REF:0000024
RGD
UniProt
PMID:14966270 GO_REF:0000024 NCBI chr 8:97,473,454...97,494,974
Ensembl chr 8:97,474,092...97,494,834
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 colocalizes_with ISO
IBA
IEA
(PMID:11486045)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:11486045, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Phf12 PHD finger protein 12 ISO (PMID:22048773) RGD PMID:22048773 NCBI chr10:64,815,462...64,863,514
Ensembl chr10:64,815,462...64,862,268
JBrowse link
G Sin3a SIN3 transcription regulator family member A ISO
IBA
(PMID:14966270), (PMID:17827154)
PMID:21873635
RGD PMID:14966270, PMID:17827154, PMID:21873635 RGD:13792537 NCBI chr 8:61,748,590...61,803,314
Ensembl chr 8:61,762,768...61,803,099
JBrowse link
G Sin3b SIN3 transcription regulator family member B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:18,842,456...18,860,086
Ensembl chr16:18,842,456...18,860,086
JBrowse link
G Sinhcaf SIN3-HDAC complex associated factor ISO
IBA
(PMID:22984288)
PMID:21873635
RGD PMID:22984288, PMID:21873635 RGD:13792537 NCBI chr 4:183,401,314...183,426,439
Ensembl chr 4:183,401,318...183,426,439
JBrowse link
G Suds3 SDS3 homolog, SIN3A corepressor complex component ISO (MGI:MGI:2670031|PMID:11909966) RGD PMID:11909966 MGI:MGI:2670031 NCBI chr12:45,199,012...45,221,507
Ensembl chr12:45,199,577...45,221,512
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      chromatin 973
        nuclear chromatin 753
          Sin3-type complex 17
            Rpd3L complex 0
            Rpd3S/Clr6-CII complex 0
            Sin3 complex 13
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13258
        membrane-bounded organelle 11449
          intracellular membrane-bounded organelle 10704
            nucleus 7183
              nuclear lumen 4262
                nuclear chromosome 963
                  nuclear chromatin 753
                    Sin3-type complex 17
                      Rpd3L complex 0
                      Rpd3S/Clr6-CII complex 0
                      Sin3 complex 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.