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ONTOLOGY REPORT - ANNOTATIONS

Term:Sin3-type complex
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Accession:GO:0070822 term browser browse the term
Definition:Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.


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Sin3-type complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brms1 BRMS1, transcriptional repressor and anoikis regulator part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:202,345,766...202,355,028
Ensembl chr 1:202,345,704...202,355,028 		JBrowse link
G Brms1l BRMS1 like transcriptional repressor part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:73,266,673...73,300,630
Ensembl chr 6:73,266,691...73,300,631 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 part_of ISO (PMID:17827154) RGD PMID:17827154 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Hdac1 histone deacetylase 1 part_of ISO (PMID:17827154) RGD PMID:17827154 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac2 histone deacetylase 2 part_of ISO (PMID:14966270), (PMID:17827154) RGD PMID:14966270 PMID:17827154 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Ing2 inhibitor of growth family, member 2 part_of ISO (PMID:16387653) RGD PMID:16387653 NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482 		JBrowse link
G Morf4l1 mortality factor 4 like 1 part_of ISS
ISO		 GO_REF:0000024
(PMID:14966270)		 UniProt
RGD		 PMID:14966270 GO_REF:0000024 NCBI chr 8:90,642,988...90,664,518
Ensembl chr 8:90,642,988...90,664,519 		JBrowse link
G Phf12 PHD finger protein 12 part_of ISO
IBA		 (PMID:22048773)
GO_REF:0000033		 RGD
GO_Central		 PMID:22048773 GO_REF:0000033 NCBI chr10:62,871,309...62,919,026
Ensembl chr10:62,872,195...62,919,000 		JBrowse link
G Sap130 Sin3A associated protein 130 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:23,244,337...23,345,368
Ensembl chr18:23,267,256...23,345,359 		JBrowse link
G Sin3a SIN3 transcription regulator family member A part_of ISO
IBA		 (PMID:14966270), (PMID:17827154)
GO_REF:0000033		 RGD
GO_Central		 PMID:14966270 PMID:17827154 GO_REF:0000033 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192 		JBrowse link
G Sinhcaf SIN3-HDAC complex associated factor part_of ISO
IBA		 (PMID:22984288)
GO_REF:0000033		 RGD
GO_Central		 PMID:22984288 GO_REF:0000033 NCBI chr 4:181,888,301...181,913,294
Ensembl chr 4:181,888,312...181,910,276 		JBrowse link
G Suds3 SDS3 homolog, SIN3A corepressor complex component part_of ISO
IBA		 (MGI:2670031|PMID:11909966)
GO_REF:0000033
(PMID:11909966)		 RGD
GO_Central		 PMID:11909966 GO_REF:0000033 MGI:2670031 NCBI chr12:39,477,181...39,499,633
Ensembl chr12:39,477,568...39,499,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20814
    cellular anatomical structure 20574
      chromatin 821
        Sin3-type complex 12
          Rpd3L complex 0
          Rpd3S complex 0
Path 2
Term Annotations click to browse term
  cellular_component 20814
    cellular anatomical structure 20574
      organelle 14007
        intracellular organelle 13599
          intracellular membrane-bounded organelle 12057
            nucleus 7485
              nuclear lumen 4086
                nucleoplasm 3587
                  histone deacetylase complex 77
                    Sin3-type complex 12
                      Rpd3L complex 0
                      Rpd3S complex 0
paths to the root