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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphorylation of RNA polymerase II C-terminal domain
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Accession:GO:0070816 term browser browse the term
Definition:The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
Synonyms:exact_synonym: CTD domain phosphorylation of RNA polymerase II;   generation of II(0) form of RNA polymerase II;   generation of hyperphosphorylated CTD of RNA polymerase II;   hyperphosphorylation of RNA polymerase II C-terminal domain
 alt_id: GO:0016245


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phosphorylation of RNA polymerase II C-terminal domain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07063323.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 6:28,557,633...28,557,848 JBrowse link
G Ccnh cyclin H involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
JBrowse link
G Cdk12 cyclin-dependent kinase 12 involved_in ISO
ISS
IBA
(PMID:20952539)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:20952539, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:86,157,186...86,210,657
Ensembl chr10:86,157,608...86,222,707
JBrowse link
G Cdk13 cyclin-dependent kinase 13 involved_in ISO
IBA
(PMID:20952539)
PMID:21873635
RGD PMID:20952539, PMID:21873635 RGD:13792537 NCBI chr17:49,833,194...49,922,932
Ensembl chr17:49,833,400...49,921,550
JBrowse link
G Cdk7 cyclin-dependent kinase 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Cdk9 cyclin-dependent kinase 9 involved_in ISS
ISO
GO_REF:0000024
(PMID:28426094)
UniProt
RGD
PMID:28426094 GO_REF:0000024 NCBI chr 3:11,742,269...11,747,117
Ensembl chr 3:11,742,266...11,747,113
JBrowse link
G Gtf2h1 general transcription factor IIH subunit 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:102,849,618...102,877,939
Ensembl chr 1:102,849,889...102,877,944
JBrowse link
G Gtf2h3 general transcription factor IIH subunit 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:37,427,556...37,444,027
Ensembl chr12:37,427,546...37,444,282
JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:3,582,688...3,588,373
Ensembl chr20:3,582,742...3,588,375
JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:46,978,345...46,985,032
Ensembl chr 1:46,978,458...46,985,032
JBrowse link
positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnk cyclin K involved_in ISO (PMID:22988298) RGD PMID:22988298 NCBI chr 6:132,090,235...132,113,560
Ensembl chr 6:132,090,218...132,113,557
JBrowse link
regulation of phosphorylation of RNA polymerase II C-terminal domain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 involved_in ISO (PMID:23086925) RGD PMID:23086925 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Ppil4 peptidylprolyl isomerase like 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:1,897,316...1,930,311
Ensembl chr 1:1,897,338...1,929,763
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    metabolic process 11881
      cellular metabolic process 10838
        phosphorus metabolic process 2894
          phosphate-containing compound metabolic process 2872
            phosphorylation 2017
              protein phosphorylation 1678
                phosphorylation of RNA polymerase II C-terminal domain 13
                  negative regulation of phosphorylation of RNA polymerase II C-terminal domain + 0
                  phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex 0
                  phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + 1
                  phosphorylation of RNA polymerase II C-terminal domain serine 5 residues + 0
                  positive regulation of phosphorylation of RNA polymerase II C-terminal domain + 1
                  regulation of phosphorylation of RNA polymerase II C-terminal domain + 3
Path 2
Term Annotations click to browse term
  biological_process 19612
    metabolic process 11881
      cellular metabolic process 10838
        cellular aromatic compound metabolic process 5627
          nucleobase-containing compound metabolic process 5410
            nucleic acid metabolic process 4921
              RNA metabolic process 4404
                RNA biosynthetic process 3418
                  nucleic acid-templated transcription 3403
                    transcription, DNA-templated 3401
                      regulation of transcription, DNA-templated 3270
                        regulation of transcription by RNA polymerase II 2385
                          phosphorylation of RNA polymerase II C-terminal domain 13
                            negative regulation of phosphorylation of RNA polymerase II C-terminal domain + 0
                            phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex 0
                            phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + 1
                            phosphorylation of RNA polymerase II C-terminal domain serine 5 residues + 0
                            positive regulation of phosphorylation of RNA polymerase II C-terminal domain + 1
                            regulation of phosphorylation of RNA polymerase II C-terminal domain + 3
paths to the root