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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphorylation of RNA polymerase II C-terminal domain
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Accession:GO:0070816 term browser browse the term
Definition:The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
Synonyms:exact_synonym: CTD domain phosphorylation of RNA polymerase II;   generation of II(0) form of RNA polymerase II;   generation of hyperphosphorylated CTD of RNA polymerase II;   hyperphosphorylation of RNA polymerase II C-terminal domain
 alt_id: GO:0016245


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phosphorylation of RNA polymerase II C-terminal domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07063323.1 RGD:13792537
G Ccnh cyclin H JBrowse link 2 13,593,100 13,613,910 RGD:13792537
G Cdk12 cyclin-dependent kinase 12 JBrowse link 10 86,157,186 86,210,657 RGD:1624291
RGD:13792537
RGD:1600115
G Cdk13 cyclin-dependent kinase 13 JBrowse link 17 49,833,194 49,922,932 RGD:1624291
RGD:13792537
G Cdk7 cyclin-dependent kinase 7 JBrowse link 2 30,710,642 30,735,522 RGD:13792537
G Cdk9 cyclin-dependent kinase 9 JBrowse link 3 11,742,269 11,747,117 RGD:1600115
RGD:1624291
G Gtf2h1 general transcription factor IIH subunit 1 JBrowse link 1 102,849,618 102,877,939 RGD:13792537
G Gtf2h3 general transcription factor IIH subunit 3 JBrowse link 12 37,427,556 37,444,027 RGD:13792537
G Gtf2h4 general transcription factor 2H subunit 4 JBrowse link 20 3,582,688 3,588,373 RGD:13792537
G Gtf2h5 general transcription factor IIH subunit 5 JBrowse link 1 46,978,345 46,985,032 RGD:13792537
positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnk cyclin K JBrowse link 6 132,090,235 132,113,560 RGD:1624291
regulation of phosphorylation of RNA polymerase II C-terminal domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:1624291
G Ppil4 peptidylprolyl isomerase like 4 JBrowse link 1 1,897,316 1,930,311 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    metabolic process 11954
      cellular metabolic process 10782
        phosphorus metabolic process 3255
          phosphate-containing compound metabolic process 3234
            phosphorylation 2413
              protein phosphorylation 1963
                phosphorylation of RNA polymerase II C-terminal domain 13
                  negative regulation of phosphorylation of RNA polymerase II C-terminal domain + 0
                  phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex 0
                  phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + 1
                  phosphorylation of RNA polymerase II C-terminal domain serine 5 residues + 0
                  positive regulation of phosphorylation of RNA polymerase II C-terminal domain + 1
                  regulation of phosphorylation of RNA polymerase II C-terminal domain + 3
Path 2
Term Annotations click to browse term
  biological_process 19678
    metabolic process 11954
      cellular metabolic process 10782
        cellular aromatic compound metabolic process 5534
          nucleobase-containing compound metabolic process 5311
            nucleic acid metabolic process 4822
              RNA metabolic process 4322
                RNA biosynthetic process 3347
                  nucleic acid-templated transcription 3335
                    transcription, DNA-templated 3287
                      regulation of transcription, DNA-templated 3174
                        regulation of transcription by RNA polymerase II 2113
                          phosphorylation of RNA polymerase II C-terminal domain 13
                            negative regulation of phosphorylation of RNA polymerase II C-terminal domain + 0
                            phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex 0
                            phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + 1
                            phosphorylation of RNA polymerase II C-terminal domain serine 5 residues + 0
                            positive regulation of phosphorylation of RNA polymerase II C-terminal domain + 1
                            regulation of phosphorylation of RNA polymerase II C-terminal domain + 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.