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ONTOLOGY REPORT - ANNOTATIONS


Term:gamma-secretase complex
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Accession:GO:0070765 term browser browse the term
Definition:A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.
Synonyms:exact_synonym: presenilin complex
 narrow_synonym: CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant);   PS1 complex;   PS2 complex;   gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant);   gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN);   gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
 related_synonym: gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)


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gamma-secretase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aph1a aph-1 homolog A, gamma secretase subunit part_of ISO
IBA
(PMID:12297508), (PMID:25043039), (PMID:26280335)
(MGI:4835615|PMID:20674680)
(MGI:3843126|PMID:19299585)
PMID:21873635
RGD PMID:12297508 PMID:19299585 PMID:20674680 PMID:25043039 PMID:26280335, PMID:21873635 MGI:3843126 MGI:4835615, RGD:13792537 NCBI chr 2:198,006,247...198,009,837
Ensembl chr 2:198,006,316...198,009,830
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit part_of ISO
IBA
UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021)
PMID:21873635
MGI:1915568 (MGI:3655012|PMID:16371134), (MGI:3804503|PMID:18626010), (MGI:3843126|PMID:19299585)
RGD PMID:12297508 PMID:12763021 PMID:16371134 PMID:18626010 PMID:19299585, PMID:21873635 MGI:3655012 MGI:3804503 MGI:3843126, RGD:13792537 NCBI chr 8:72,508,008...72,598,921
Ensembl chr 8:72,476,425...72,629,265
JBrowse link
G Ncstn nicastrin part_of ISO
ISS
UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335)
(MGI:3623864|PMID:16641999), (MGI:3655012|PMID:16371134), (MGI:4835615|PMID:20674680)
GO_REF:0000024
RGD
UniProt
PMID:12297508 PMID:12763021 PMID:16371134 PMID:16641999 PMID:20674680 PMID:25043039 PMID:26280335 GO_REF:0000024 MGI:3623864 MGI:3655012 MGI:4835615 NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
JBrowse link
G Psen1 presenilin 1 part_of ISO
ISS
UniProtKB:P05067 (PMID:10801983), (PMID:12297508), (PMID:12763021), (PMID:26280335)
(MGI:2665226|PMID:12684521), (MGI:3623864|PMID:16641999), (MGI:3655012|PMID:16371134), (MGI:4835615|PMID:20674680)
GO_REF:0000024
RGD
UniProt
PMID:10801983 PMID:12297508 PMID:12684521 PMID:12763021 PMID:16371134 PMID:16641999 PMID:20674680 PMID:26280335 GO_REF:0000024 MGI:2665226 MGI:3623864 MGI:3655012 MGI:4835615 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psen2 presenilin 2 part_of ISO (PMID:12297508)
(MGI:2665226|PMID:12684521)
RGD PMID:12297508 PMID:12684521 MGI:2665226 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit part_of ISS
ISO
IBA
GO_REF:0000024
(MGI:3623864|PMID:16641999), (MGI:3655012|PMID:16371134)
PMID:21873635
UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:25043039), (PMID:26280335)
UniProt
RGD
PMID:12763021 PMID:16371134 PMID:16641999 PMID:25043039 PMID:26280335, PMID:21873635 GO_REF:0000024 MGI:3623864 MGI:3655012, RGD:13792537 NCBI chr 1:89,016,093...89,017,449
Ensembl chr 1:89,016,096...89,017,290
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 part_of IDA
ISO
(MGI:3623864|PMID:16641999)
(PMID:16641999)
RGD PMID:16641999, PMID:19754663 MGI:3623864, RGD:2317342 NCBI chr 6:109,169,739...109,205,004
Ensembl chr 6:109,169,741...109,205,004
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20126
    protein-containing complex 6038
      membrane protein complex 1243
        plasma membrane protein complex 564
          gamma-secretase complex 7
Path 2
Term Annotations click to browse term
  cellular_component 20126
    cellular anatomical entity 19825
      membrane 10001
        plasma membrane 6218
          plasma membrane protein complex 564
            gamma-secretase complex 7
paths to the root