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ONTOLOGY REPORT - ANNOTATIONS

Term:tubulin-glutamic acid ligase activity
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Accession:GO:0070740 term browser browse the term
Definition:Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.
Synonyms:exact_synonym: tubulin glutamylase activity;   tubulin-glutamate ligase activity
 xref: EC:6.3.2.61;   reactome:R-HSA-8865774 "TTLLs polyglutamylate tubulin";   reactome:R-HSA-8955869 "Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin"


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tubulin-glutamic acid ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tpgs1 tubulin polyglutamylase complex subunit 1 enables ISO
IBA
IEA		 (PMID:17360631)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:17360631 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:10,680,461...10,686,383
Ensembl chr 7:10,029,854...10,035,764 		JBrowse link
G Ttll1 TTL family tubulin polyglutamylase complex subunit L1 enables ISO
IEA
IBA		 (PMID:34782749)
GO_REF:0000117
GO_REF:0000033
(PMID:15890843), (PMID:30420556)
GO_REF:0000107		 RGD
UniProt
GO_Central
Ensembl		 PMID:15890843 PMID:30420556 PMID:34782749 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 7:116,499,536...116,528,833
Ensembl chr 7:114,619,508...114,648,761 		JBrowse link
G Ttll11 tubulin tyrosine ligase like 11 enables ISO
IBA
IEA		 (PMID:17499049), (PMID:20530212)
GO_REF:0000033
GO_REF:0000117		 RGD
GO_Central
UniProt		 PMID:17499049 PMID:20530212 GO_REF:0000033 GO_REF:0000117 NCBI chr 3:39,507,714...39,732,893
Ensembl chr 3:19,110,284...19,335,969 		JBrowse link
G Ttll13 tubulin tyrosine ligase like 13 enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:17499049)
GO_REF:0000117
GO_REF:0000107		 GO_Central
RGD
UniProt
Ensembl		 PMID:17499049 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 1:134,197,801...134,213,083
Ensembl chr 1:134,197,801...134,218,718 		JBrowse link
G Ttll2 tubulin tyrosine ligase like 2 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000117		 GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:52,967,183...52,976,690
Ensembl chr 1:52,968,408...52,976,697 		JBrowse link
G Ttll4 tubulin tyrosine ligase like 4 enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:17499049), (PMID:21074048)
GO_REF:0000117
GO_REF:0000107		 GO_Central
RGD
UniProt
Ensembl		 PMID:17499049 PMID:21074048 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 9:76,221,659...76,258,219
Ensembl chr 9:76,221,796...76,251,301 		JBrowse link
G Ttll5 tubulin tyrosine ligase like 5 enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:17499049)
GO_REF:0000117
GO_REF:0000107		 GO_Central
RGD
UniProt
Ensembl		 PMID:17499049 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 6:111,214,048...111,431,892
Ensembl chr 6:105,483,191...105,700,934 		JBrowse link
G Ttll6 tubulin tyrosine ligase like 6 enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:17499049), (PMID:20530212), (PMID:21074048), (PMID:32747782)
GO_REF:0000117		 GO_Central
RGD
UniProt		 PMID:17499049 PMID:20530212 PMID:21074048 PMID:32747782 GO_REF:0000033 GO_REF:0000117 NCBI chr10:81,081,985...81,118,009
Ensembl chr10:81,091,975...81,127,234 		JBrowse link
G Ttll7 tubulin tyrosine ligase like 7 enables ISO
IBA
IEA		 (PMID:25959773)
GO_REF:0000033
(PMID:16901895), (PMID:17499049), (PMID:19152315)
GO_REF:0000117
GO_REF:0000107		 RGD
GO_Central
UniProt
Ensembl		 PMID:16901895 PMID:17499049 PMID:19152315 PMID:25959773 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 2:235,765,786...235,889,047
Ensembl chr 2:235,765,835...235,885,047 		JBrowse link
G Ttll9 tubulin tyrosine ligase like 9 enables ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000117
GO_REF:0000033
(PMID:27257088)		 UniProt
GO_Central
RGD		 PMID:27257088 GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 NCBI chr 3:141,429,351...141,475,965
Ensembl chr 3:141,429,444...141,475,865 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      catalytic activity, acting on a protein 2531
        protein-glutamic acid ligase activity 10
          tubulin-glutamic acid ligase activity 10
Path 2
Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      ligase activity 180
        ligase activity, forming carbon-nitrogen bonds 53
          acid-amino acid ligase activity 25
            protein-glutamic acid ligase activity 10
              tubulin-glutamic acid ligase activity 10
paths to the root