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ONTOLOGY REPORT - ANNOTATIONS

Term:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
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Accession:GO:0070626 term browser browse the term
Definition:Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
Synonyms:broad_synonym: adenylosuccinase activity;   adenylosuccinate lyase activity;   succino AMP-lyase activity
 related_synonym: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity;   SAICAR-lyase (fumarate forming) activity
 xref: EC:4.3.2.2;   KEGG_REACTION:R04559;   MetaCyc:AICARSYN-RXN;   RHEA:23920;   Reactome:R-HSA-73800 "SAICAR => AICAR + Fumarate";   Reactome:R-HSA-73828 "adenylosuccinate => adenosine 5'-monophosphate + fumarate"


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(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADSL adenylosuccinate lyase enables ISO
IEA
IBA		 RGD
UniProt
RHEA
Ensembl
TreeGrafter
GO_Central		 PMID:3759987 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:5135303 NCBI chr 5:8,027,799...8,045,480
Ensembl chr 5:8,025,508...8,047,603 		JBrowse link
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  molecular_function 18689
    catalytic activity 5662
      lyase activity 202
        carbon-nitrogen lyase activity 14
          amidine-lyase activity 7
            (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity 1
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