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ONTOLOGY REPORT - ANNOTATIONS

Term:RISC-loading complex
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Accession:GO:0070578 term browser browse the term
Definition:A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
Synonyms:exact_synonym: miRLC;   microRNA loading complex
 related_synonym: RLC


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RISC-loading complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago1 argonaute RISC component 1 part_of ISO (PMID:19966796) RGD PMID:19966796 NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 part_of
located_in		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15973356), (PMID:17531811), (PMID:18178619), (PMID:19820710), (PMID:19966796), (PMID:23661684)
(MGI:5616320|PMID:16357216)
(PMID:23661684)		 UniProt
Ensembl
RGD		 PMID:15973356 PMID:16357216 PMID:17531811 PMID:18178619 PMID:19820710 More... GO_REF:0000024 GO_REF:0000107 MGI:5616320 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 part_of ISO (PMID:19966796) RGD PMID:19966796 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
G Ago4 argonaute RISC component 4 part_of ISO (PMID:19966796) RGD PMID:19966796 NCBI chr 5:138,780,446...138,825,898
Ensembl chr 5:138,783,069...138,825,632 		JBrowse link
G Dhx9 DExH-box helicase 9 part_of ISO (PMID:17531811) RGD PMID:17531811 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069 		JBrowse link
G Dicer1 dicer 1 ribonuclease III part_of
located_in		 ISO
IBA		 (PMID:15973356), (PMID:16357216), (PMID:17531811), (PMID:18178619), (PMID:19820710), (PMID:23661684)
(PMID:23661684)
GO_REF:0000033		 RGD
GO_Central		 PMID:15973356 PMID:16357216 PMID:17531811 PMID:18178619 PMID:19820710 More... GO_REF:0000033 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Mir27a microRNA 27a part_of ISO (PMID:22503104) RGD PMID:22503104 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
G Mir28 microRNA 28 part_of ISO (PMID:22503104) RGD PMID:22503104 NCBI chr11:75,975,523...75,975,608
Ensembl chr11:75,975,523...75,975,608 		JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 part_of
located_in		 ISO
IEA
IBA		 (PMID:23661684)
GO_REF:0000107
GO_REF:0000118
GO_REF:0000033		 RGD
Ensembl
TreeGrafter
GO_Central		 PMID:23661684 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:61,575,447...61,594,393
Ensembl chr 3:61,575,447...61,594,347 		JBrowse link
G Tarbp2 Tarbp2 subunit of RISC loading complex part_of
located_in		 ISO
ISS
IEA
IBA		 (PMID:15973356), (PMID:16357216), (PMID:17531811), (PMID:18178619), (PMID:19820710), (PMID:23661684)
GO_REF:0000024
GO_REF:0000002
GO_REF:0000118
GO_REF:0000033
(PMID:23661684)		 RGD
UniProt
InterPro
TreeGrafter
GO_Central		 PMID:15973356 PMID:16357216 PMID:17531811 PMID:18178619 PMID:19820710 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:133,649,118...133,654,306
Ensembl chr 7:133,649,090...133,654,314 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  cellular_component 21392
    protein-containing complex 6987
      catalytic complex 1938
        endonuclease complex 40
          endoribonuclease complex 35
            RISC-loading complex 10
paths to the root