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ONTOLOGY REPORT - ANNOTATIONS

Term:endoribonuclease activity, cleaving siRNA-paired mRNA
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Accession:GO:0070551 term browser browse the term
Definition:Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters.
Synonyms:related_synonym: argonaute endoribonuclease activity
 xref: Reactome:R-HSA-9820842 "AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote"


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endoribonuclease activity, cleaving siRNA-paired mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic component 2 enables IEA
ISO
ISS		 GO_REF:0000107
(PMID:15260970), (PMID:17524464)
GO_REF:0000024
GO_REF:0000002		 Ensembl
RGD
UniProt
InterPro		 PMID:15260970 PMID:17524464 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      catalytic activity, acting on a nucleic acid 638
        catalytic activity, acting on RNA 399
          RNA nuclease activity 139
            RNA endonuclease activity 73
              RNA endonuclease activity, producing 5'-phosphomonoesters 33
                endoribonuclease activity, cleaving siRNA-paired mRNA 1
Path 2
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      hydrolase activity 2630
        hydrolase activity, acting on ester bonds 837
          nuclease activity 232
            endonuclease activity 134
              RNA endonuclease activity 73
                RNA endonuclease activity, producing 5'-phosphomonoesters 33
                  endoribonuclease activity, cleaving siRNA-paired mRNA 1
paths to the root