ONTOLOGY REPORT - ANNOTATIONS
Term: protein K63-linked ubiquitination
Accession: GO:0070534
browse the term
Definition: A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
Synonyms: exact_synonym: protein K63-linked polyubiquitination
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AABR07067339.1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
Ensembl chr 8:96,977,420...96,977,861
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Arih2
ariadne RBR E3 ubiquitin protein ligase 2
involved_in
ISO
(PMID:19340006)
RGD
PMID:19340006
NCBI chr 8:109,296,738...109,355,909
Ensembl chr 8:109,296,738...109,355,852
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Arrdc4
arrestin domain containing 4
involved_in
ISO
(PMID:28594402)
RGD
PMID:28594402
NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290
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Bfar
bifunctional apoptosis regulator
involved_in
ISO
(PMID:21068390)
RGD
PMID:21068390
NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
involved_in
ISS ISO
GO_REF:0000024 (PMID:18305112)
UniProt RGD
PMID:18305112
GO_REF:0000024
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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ENSRNOG00000064433
involved_in
IEA
GO_REF:0000118
TreeGrafter
GO_REF:0000118
Ensembl chr 9:21,357,764...21,358,219
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ENSRNOG00000067007
involved_in
IEA
GO_REF:0000118
TreeGrafter
GO_REF:0000118
Ensembl chr14:4,704,512...4,705,318
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ENSRNOG00000068565
involved_in
IEA
GO_REF:0000118
TreeGrafter
GO_REF:0000118
Ensembl chr20:35,389,879...35,390,324
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Fbxw7
F-box and WD repeat domain containing 7
involved_in
ISS
GO_REF:0000024
UniProt
GO_REF:0000024
NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941
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Hectd1
HECT domain E3 ubiquitin protein ligase 1
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 MGI:2137552|MGI:3706565 (PMID:22431752)
GO_Central RGD
PMID:22431752
GO_REF:0000033
NCBI chr 6:69,181,429...69,268,045
Ensembl chr 6:69,181,436...69,268,053
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Itch
itchy E3 ubiquitin protein ligase
involved_in
IBA ISO
GO_REF:0000033 (PMID:18718448), (PMID:19592251), (PMID:29378950)
GO_Central RGD
PMID:18718448 PMID:19592251 PMID:29378950
GO_REF:0000033
NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
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Kcmf1
potassium channel modulatory factor 1
involved_in
ISO
(PMID:34893540)
RGD
PMID:34893540
NCBI chr 4:104,888,452...104,950,234
Ensembl chr 4:104,889,847...104,950,234
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Magel2
MAGE family member L2
involved_in
ISO
(PMID:23452853)
RGD
PMID:23452853
NCBI chr 1:115,880,142...115,884,684
Ensembl chr 1:115,880,474...115,884,250
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Nedd4
NEDD4 E3 ubiquitin protein ligase
involved_in
IDA
PMID:20159449
UniProt
PMID:20159449
RGD:8554407
NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
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Peli1
pellino E3 ubiquitin protein ligase 1
involved_in
ISO
(PMID:29883609), (PMID:30952868), (PMID:33215753)
RGD
PMID:29883609 PMID:30952868 PMID:33215753
NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285
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Peli3
pellino E3 ubiquitin protein ligase family member 3
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 (PMID:23892723)
GO_Central RGD
PMID:23892723
GO_REF:0000033
NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:202,232,228...202,242,857
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Pnkp
polynucleotide kinase 3'-phosphatase
involved_in
ISO
(MGI:5780352|PMID:26774286)
RGD
PMID:26774286
MGI:5780352
NCBI chr 1:95,341,465...95,346,921
Ensembl chr 1:95,341,620...95,346,920
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Prkn
parkin RBR E3 ubiquitin protein ligase
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:15728840), (PMID:17314283), (PMID:19880420), (PMID:25621951) GO_REF:0000107
ParkinsonsUK-UCL RGD Ensembl
PMID:15728840 PMID:17314283 PMID:19880420 PMID:25621951
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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Prpf19
pre-mRNA processing factor 19
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000104 (PMID:20595234), (PMID:24332808)
UniProt RGD
PMID:20595234 PMID:24332808
GO_REF:0000024 GO_REF:0000104
NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662
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Rnf115
ring finger protein 115
involved_in
ISO
(MGI:5582879|PMID:23418353)
RGD
PMID:23418353
MGI:5582879
NCBI chr 2:184,262,087...184,329,839
Ensembl chr 2:184,262,371...184,329,823
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Rnf126
ring finger protein 126
involved_in
ISO
(MGI:5582879|PMID:23418353)
RGD
PMID:23418353
MGI:5582879
NCBI chr 7:9,939,359...9,946,963
Ensembl chr 7:9,938,229...9,946,738
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Rnf135
ring finger protein 135
involved_in
ISS ISO
GO_REF:0000024 (PMID:31006531)
UniProt RGD
PMID:31006531
GO_REF:0000024
NCBI chr10:65,170,560...65,189,791
Ensembl chr10:65,170,560...65,262,804
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Rnf152
ring finger protein 152
involved_in
ISS ISO
GO_REF:0000024 (PMID:25936802)
UniProt RGD
PMID:25936802
GO_REF:0000024
NCBI chr13:21,324,039...21,403,405
Ensembl chr13:21,323,824...21,403,113
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Rnf167
ring finger protein 167
involved_in
ISO
(PMID:35114100)
RGD
PMID:35114100
NCBI chr10:55,360,603...55,364,927
Ensembl chr10:55,360,543...55,364,927
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Rnf168
ring finger protein 168
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:22266820)
UniProt Ensembl RGD
PMID:22266820
GO_REF:0000024 GO_REF:0000107
NCBI chr11:68,486,313...68,508,296
Ensembl chr11:68,486,321...68,508,277
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Rnf186
ring finger protein 186
involved_in
ISO IBA
(PMID:23896122) GO_REF:0000033
RGD GO_Central
PMID:23896122
GO_REF:0000033
NCBI chr 5:151,210,492...151,211,716
Ensembl chr 5:151,210,492...151,211,716
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Rnf213
ring finger protein 213
involved_in
ISO
(PMID:32139119), (PMID:33842849)
RGD
PMID:32139119 PMID:33842849
NCBI chr10:104,656,329...104,755,669
Ensembl chr10:104,656,883...104,757,918
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Rnf4
ring finger protein 4
involved_in
IDA
PMID:18408734
UniProt
PMID:18408734
RGD:8553731
NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566
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Rnf5
ring finger protein 5
involved_in
ISO
(PMID:19269966)
RGD
PMID:19269966
NCBI chr20:4,145,539...4,147,985
Ensembl chr20:4,145,507...4,147,985
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Rnf8
ring finger protein 8
involved_in
ISS ISO
GO_REF:0000024 (PMID:21911360)
UniProt RGD
PMID:21911360
GO_REF:0000024
NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491
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Skp2
S-phase kinase associated protein 2
involved_in
ISO
(PMID:22464731) (MGI:5438910|PMID:22464731)
RGD
PMID:22464731
MGI:5438910
NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
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Stub1
STIP1 homology and U-box containing protein 1
involved_in
ISO
(PMID:16307917)
RGD
PMID:16307917
NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046
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Traf1
TNF receptor-associated factor 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
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Traf2
Tnf receptor-associated factor 2
involved_in
ISO IBA
(PMID:15258597), (PMID:20577214) GO_REF:0000033
RGD GO_Central
PMID:15258597 PMID:20577214
GO_REF:0000033
NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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Traf3
Tnf receptor-associated factor 3
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
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Traf3ip2
Traf3 interacting protein 2
involved_in
ISO
(PMID:19825828)
RGD
PMID:19825828
NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667
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Traf4
Tnf receptor associated factor 4
involved_in
IEA
GO_REF:0000118
TreeGrafter
GO_REF:0000118
NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284
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Traf5
TNF receptor-associated factor 5
involved_in
IBA IEA
GO_REF:0000033 GO_REF:0000118
GO_Central TreeGrafter
GO_REF:0000033 GO_REF:0000118
NCBI chr13:103,569,944...103,618,747
Ensembl chr13:103,572,314...103,618,709
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Traf6
TNF receptor associated factor 6
involved_in
ISS IBA ISO IEA
GO_REF:0000024 GO_REF:0000033 UniProtKB:P0CG47 (PMID:17135271), (PMID:19675569), (PMID:19713527), (PMID:20038579), (PMID:21068390), (PMID:23015697), (PMID:23524951), (PMID:33799071) GO_REF:0000107 (MGI:3610521|PMID:16252010)
UniProt GO_Central RGD Ensembl
PMID:16252010 PMID:17135271 PMID:19675569 PMID:19713527 PMID:20038579 PMID:21068390 PMID:23015697 PMID:23524951 PMID:33799071 More...
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:3610521
NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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Trim21
tripartite motif-containing 21
involved_in
ISO
(PMID:26342464), (PMID:36692217), (PMID:37816088)
RGD
PMID:26342464 PMID:36692217 PMID:37816088
NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440
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Trim27
tripartite motif-containing 27
involved_in
ISO IBA
(PMID:23452853) GO_REF:0000033
RGD GO_Central
PMID:23452853
GO_REF:0000033
NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643
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Trim3
tripartite motif-containing 3
involved_in
IEA ISO
GO_REF:0000107 (PMID:32878999)
Ensembl RGD
PMID:32878999
GO_REF:0000107
NCBI chr 1:159,950,921...159,973,600
Ensembl chr 1:159,944,908...159,973,600
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Trim31
tripartite motif-containing 31
involved_in
ISO
(PMID:27992402)
RGD
PMID:27992402
NCBI chr20:1,653,165...1,666,494
Ensembl chr20:1,653,165...1,666,494
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Trim32
tripartite motif-containing 32
involved_in
ISO
(PMID:37943659)
RGD
PMID:37943659
NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018
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Trim5
tripartite motif-containing 5
involved_in
ISO
(PMID:21512573)
RGD
PMID:21512573
NCBI chr 1:158,720,407...158,737,393
Ensembl chr 1:158,720,410...158,814,012
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Trim56
tripartite motif containing 56
involved_in
ISO
(MGI:4849871|PMID:21074459)
RGD
PMID:21074459
MGI:4849871
NCBI chr12:19,544,913...19,567,324
Ensembl chr12:19,551,521...19,567,462
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Trim65
tripartite motif-containing 65
involved_in
ISO
(PMID:28594402) (PMID:28031478)
RGD
PMID:28031478 PMID:28594402
NCBI chr10:101,357,937...101,364,036
Ensembl chr10:101,357,937...101,364,971
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Trim8
tripartite motif-containing 8
involved_in
ISO
(PMID:27995356)
RGD
PMID:27995356
NCBI chr 1:245,369,632...245,384,513
Ensembl chr 1:245,369,632...245,384,513
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Ube2b
ubiquitin-conjugating enzyme E2B
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:20061386)
UniProt Ensembl RGD
PMID:20061386
GO_REF:0000024 GO_REF:0000107
NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
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Ube2d2b
ubiquitin-conjugating enzyme E2D 2B
involved_in
ISO
(PMID:20061386)
RGD
PMID:20061386
NCBI chr14:1,915,999...1,917,473
Ensembl chr14:1,916,845...1,917,416
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Ube2e2
ubiquitin-conjugating enzyme E2E 2
involved_in
ISO IBA
(PMID:20061386) GO_REF:0000033
RGD GO_Central
PMID:20061386
GO_REF:0000033
NCBI chr15:6,980,241...7,257,912
Ensembl chr15:6,980,474...7,257,532
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Ube2e3
ubiquitin-conjugating enzyme E2E 3
involved_in
ISO IBA
(PMID:20061386) GO_REF:0000033
RGD GO_Central
PMID:20061386
GO_REF:0000033
NCBI chr 3:63,786,976...63,851,400
Ensembl chr 3:63,786,650...63,843,237
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Ube2g1
ubiquitin-conjugating enzyme E2G 1
involved_in
ISS ISO
GO_REF:0000024 (PMID:20061386)
UniProt RGD
PMID:20061386
GO_REF:0000024
NCBI chr10:57,225,963...57,306,748
Ensembl chr10:57,225,952...57,308,568
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Ube2n
ubiquitin-conjugating enzyme E2N
involved_in
ISS IBA ISO
GO_REF:0000024 GO_REF:0000033 (MGI:5896692|PMID:28039360), (MGI:6148454|PMID:22424771) (PMID:16307917), (PMID:20061386), (PMID:21512573), (PMID:25936802), (PMID:31006531)
UniProt GO_Central RGD
PMID:16307917 PMID:20061386 PMID:21512573 PMID:22424771 PMID:25936802 PMID:28039360 PMID:31006531 More...
GO_REF:0000024 GO_REF:0000033 MGI:5896692 MGI:6148454
NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
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Ube2o
ubiquitin-conjugating enzyme E2O
involved_in
ISO
(PMID:23452853)
RGD
PMID:23452853
NCBI chr10:101,765,572...101,812,736
Ensembl chr10:101,766,005...101,812,899
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Ube2s
ubiquitin-conjugating enzyme E2S
involved_in
ISS ISO
GO_REF:0000024 (PMID:20061386)
UniProt RGD
PMID:20061386
GO_REF:0000024
NCBI chr 1:69,028,853...69,032,914
Ensembl chr 1:69,028,750...69,032,914
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Ube2t
ubiquitin-conjugating enzyme E2T
involved_in
ISO
(PMID:20061386)
RGD
PMID:20061386
NCBI chr13:46,403,352...46,413,854
Ensembl chr13:46,403,375...46,414,835
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Ube2v1
ubiquitin conjugating enzyme E2 V1
involved_in
ISO IBA
(PMID:16307917), (PMID:21512573), (PMID:31006531) GO_REF:0000033
RGD GO_Central
PMID:16307917 PMID:21512573 PMID:31006531
GO_REF:0000033
NCBI chr 3:156,317,339...156,340,198
Ensembl chr 3:156,316,781...156,340,273
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Ube2v1l1
ubiquitin conjugating enzyme E2 V1 like 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr14:4,703,243...4,704,962
Ensembl chr 3:156,316,781...156,340,273
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Ube2v2
ubiquitin conjugating enzyme E2 V2
involved_in
IEA IBA
GO_REF:0000118 GO_REF:0000033
TreeGrafter GO_Central
GO_REF:0000033 GO_REF:0000118
NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369
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Ubr2
ubiquitin protein ligase E3 component n-recognin 2
involved_in
ISO
(PMID:38225265)
RGD
PMID:38225265
NCBI chr 9:13,982,427...14,062,315
Ensembl chr 9:13,982,329...14,062,139
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Wwp2
WW domain containing E3 ubiquitin protein ligase 2
involved_in
ISO IBA
(MGI:4821930|PMID:19997087) GO_REF:0000033
RGD GO_Central
PMID:19997087
GO_REF:0000033 MGI:4821930
NCBI chr19:35,346,826...35,471,251
Ensembl chr19:35,346,814...35,472,699
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Xiap
X-linked inhibitor of apoptosis
involved_in
ISO IEA
(PMID:29452636) GO_REF:0000107
RGD Ensembl
PMID:29452636
GO_REF:0000107
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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Zfp598
zinc finger protein 598
involved_in
ISO
(PMID:36302773)
RGD
PMID:36302773
NCBI chr10:13,694,224...13,706,235
Ensembl chr10:13,694,286...13,706,233
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Zfp91
zinc finger protein 91
involved_in
ISO
(PMID:20682767)
RGD
PMID:20682767
NCBI chr 1:209,891,344...209,928,890
Ensembl chr 1:209,891,344...209,927,762
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Cep63
centrosomal protein 63
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:35989368) GO_REF:0000107
UniProt RGD Ensembl
PMID:35989368
GO_REF:0000024 GO_REF:0000107
NCBI chr 8:103,162,639...103,214,177
Ensembl chr 8:103,162,700...103,214,177
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Gps2
G protein pathway suppressor 2
involved_in
ISO
(MGI:5896692|PMID:28039360), (MGI:6148392|PMID:24953653), (MGI:6148396|PMID:29499132), (MGI:6148454|PMID:22424771)
RGD
PMID:22424771 PMID:24953653 PMID:28039360 PMID:29499132
MGI:5896692 MGI:6148392 MGI:6148396 MGI:6148454
NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
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Mir138-1
microRNA 138-1
involved_in
ISO
(PMID:23319823)
RGD
PMID:23319823
NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064
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Mir138-2
microRNA 138-2
involved_in
ISO
(PMID:23319823)
RGD
PMID:23319823
NCBI chr19:10,674,193...10,674,274
Ensembl chr19:10,674,193...10,674,274
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Parp10
poly (ADP-ribose) polymerase family, member 10
involved_in
ISO
(PMID:23575687)
RGD
PMID:23575687
NCBI chr 7:107,949,031...107,958,377
Ensembl chr 7:107,949,043...107,958,304
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Plaa
phospholipase A2, activating protein
involved_in
ISS ISO
GO_REF:0000024 (MGI:5883825|PMID:28413018)
UniProt RGD
PMID:28413018
GO_REF:0000024 MGI:5883825
NCBI chr 5:109,428,600...109,460,373
Ensembl chr 5:109,428,265...109,460,282
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Birc2
baculoviral IAP repeat-containing 2
involved_in
ISO
(PMID:21931591)
RGD
PMID:21931591
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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Ddx3x
DEAD-box helicase 3, X-linked
involved_in
ISO
(PMID:27980081)
RGD
PMID:27980081
NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168
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Nod2
nucleotide-binding oligomerization domain containing 2
involved_in
ISO
(PMID:25891078)
RGD
PMID:25891078
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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Ptpn22
protein tyrosine phosphatase, non-receptor type 22
involved_in
ISO
(PMID:23871208) (MGI:5562517|PMID:23871208)
RGD
PMID:23871208
MGI:5562517
NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
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Ripk2
receptor-interacting serine-threonine kinase 2
involved_in
ISO
(PMID:17562858)
RGD
PMID:17562858
NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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Ube2n
ubiquitin-conjugating enzyme E2N
involved_in
ISO
(PMID:10089880), (PMID:11057907)
RGD
PMID:10089880 PMID:11057907
NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
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Ube2v1
ubiquitin conjugating enzyme E2 V1
involved_in
ISO
(PMID:11057907)
RGD
PMID:11057907
NCBI chr 3:156,317,339...156,340,198
Ensembl chr 3:156,316,781...156,340,273
G
Ube2v2
ubiquitin conjugating enzyme E2 V2
involved_in
ISO
(PMID:10089880)
RGD
PMID:10089880
NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369
G
Sash1
SAM and SH3 domain containing 1
acts_upstream_of_or_within
ISO
(PMID:23776175)
RGD
PMID:23776175
NCBI chr 1:3,119,915...3,418,536
Ensembl chr 1:3,121,332...3,439,870
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all