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Term:ERCC4-ERCC1 complex
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Accession:GO:0070522 term browser browse the term
Definition:A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae.
Comment:Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
Synonyms:exact_synonym: Rad1-Rad10 complex;   XPF-ERCC1 complex

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ERCC4-ERCC1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO
(PMID:14690602), (PMID:17055345)
RGD PMID:14690602, PMID:17055345, PMID:21873635 RGD:13792537 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit ISO (PMID:14690602), (PMID:17055345) RGD PMID:14690602, PMID:17055345 NCBI chr10:2,010,140...2,037,953
Ensembl chr10:2,010,648...2,037,891
JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit colocalizes_with ISO (PMID:19595721), (PMID:19596235), (PMID:19596236) RGD PMID:19595721, PMID:19596235, PMID:19596236 NCBI chr10:11,787,756...11,808,326
Ensembl chr10:11,786,121...11,807,928
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 ISO (MGI:MGI:3758502|PMID:14690602) RGD PMID:14690602 MGI:MGI:3758502 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 ISO (MGI:MGI:3758502|PMID:14690602) RGD PMID:14690602 MGI:MGI:3758502 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20610
    protein-containing complex 6105
      DNA repair complex 37
        nucleotide-excision repair complex 14
          ERCC4-ERCC1 complex 5
Path 2
Term Annotations click to browse term
  cellular_component 20610
    cellular anatomical entity 20359
      organelle 13271
        membrane-bounded organelle 11457
          intracellular membrane-bounded organelle 10714
            nucleus 7188
              nucleotide-excision repair complex 14
                ERCC4-ERCC1 complex 5
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.