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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-1-mediated signaling pathway
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Accession:GO:0070498 term browser browse the term
Definition:A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: IL-1-mediated signaling pathway;   interleukin-1-mediated signalling pathway
 narrow_synonym: IL-1 alpha-mediated signaling pathway;   IL-1 beta-mediated signaling pathway;   interleukin-1 alpha-mediated signaling pathway;   interleukin-1 beta-mediated signaling pathway


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interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:1624291
RGD:1600115
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:1600115
RGD:1624291
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:5130945
RGD:13792537
RGD:1624291
RGD:1600115
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
RGD:13792537
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:1624291
RGD:13792537
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:1624291
RGD:13792537
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:1624291
G Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:1624291
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:1624291
RGD:1600115
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G Rps6ka4 ribosomal protein S6 kinase A4 JBrowse link 1 222,087,328 222,098,284 RGD:1624291
G Rps6ka5 ribosomal protein S6 kinase A5 JBrowse link 6 124,557,892 124,735,787 RGD:1624291
G St18 ST18 C2H2C-type zinc finger transcription factor JBrowse link 5 12,437,617 12,787,223 RGD:1600115
RGD:1624291
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Tnip2 TNFAIP3 interacting protein 2 JBrowse link 14 81,487,934 81,505,889 RGD:1624291
G Tollip toll interacting protein JBrowse link 1 214,823,993 214,844,861 RGD:1624291
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:5130945
RGD:13792537
RGD:1624291
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:1624291
RGD:1600115
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:1600115
RGD:13792537
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
G Otud4 OTU deubiquitinase 4 JBrowse link 19 31,895,753 31,942,509 RGD:1624291
RGD:13792537
positive regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:1624291
RGD:1600115
regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vrk2 VRK serine/threonine kinase 2 JBrowse link 14 110,739,835 110,883,836 RGD:1624291
G Zbp1 Z-DNA binding protein 1 JBrowse link 3 171,276,062 171,292,062 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    signaling 7531
      signal transduction 6946
        cell surface receptor signaling pathway 2759
          cytokine-mediated signaling pathway 402
            interleukin-1-mediated signaling pathway 25
              negative regulation of interleukin-1-mediated signaling pathway 4
              positive regulation of interleukin-1-mediated signaling pathway 1
              regulation of interleukin-1-mediated signaling pathway + 7
Path 2
Term Annotations click to browse term
  biological_process 19678
    response to stimulus 10494
      response to chemical 6300
        response to organic substance 3830
          cellular response to organic substance 2822
            cellular response to cytokine stimulus 993
              cytokine-mediated signaling pathway 402
                interleukin-1-mediated signaling pathway 25
                  negative regulation of interleukin-1-mediated signaling pathway 4
                  positive regulation of interleukin-1-mediated signaling pathway 1
                  regulation of interleukin-1-mediated signaling pathway + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.