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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:thrombin-activated receptor signaling pathway
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Accession:GO:0070493 term browser browse the term
Definition:A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms:exact_synonym: thrombin receptor signaling pathway;   thrombin receptor signalling pathway


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thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IDA (PMID:15632189) UniProt PMID:15632189 NCBI chr 4:958,887...973,569
Ensembl chr 4:958,887...986,895 		JBrowse link
G F2R coagulation factor II thrombin receptor involved_in
acts_upstream_of_or_within		 IEA
IDA
ISO		 (PMID:1672265)
(PMID:18398001)		 InterPro
UniProt
GOC
MGI
Ensembl		 PMID:1672265 PMID:18398001 GO_REF:0000002 GO_REF:0000107 GO_REF:0000108 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315 		JBrowse link
G F2RL2 coagulation factor II thrombin receptor like 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:76,615,482...76,623,403
Ensembl chr 5:76,615,482...76,623,413 		JBrowse link
G F2RL3 F2R like thrombin or trypsin receptor 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr19:16,888,999...16,892,606
Ensembl chr19:16,888,999...16,892,606 		JBrowse link
G GP1BA glycoprotein Ib platelet subunit alpha involved_in IEA GOC GO_REF:0000108 NCBI chr17:4,932,277...4,935,023
Ensembl chr17:4,932,277...4,935,023 		JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:174,490,175...174,522,893
Ensembl chr 4:174,490,175...174,523,154 		JBrowse link
G IQGAP2 IQ motif containing GTPase activating protein 2 involved_in IDA (PMID:12515716) UniProt PMID:12515716 NCBI chr 5:76,403,285...76,708,132
Ensembl chr 5:76,403,285...76,708,132 		JBrowse link
G PLEK pleckstrin involved_in IEA
IDA		 (PMID:7782310) Ensembl
BHF-UCL		 PMID:7782310 GO_REF:0000107 NCBI chr 2:68,365,282...68,397,453
Ensembl chr 2:68,365,282...68,397,453 		JBrowse link
G VPS54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:63,892,150...64,019,428
Ensembl chr 2:63,892,146...64,019,428 		JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MET MET proto-oncogene, receptor tyrosine kinase involved_in IDA (PMID:25198505) CAFA PMID:25198505 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377 		JBrowse link
G SNCA synuclein alpha involved_in IDA (PMID:12239163) UniProt PMID:12239163 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
G STMN1 stathmin 1 involved_in IMP (PMID:25198505) CAFA PMID:25198505 NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    cellular process 18300
      signal transduction 6573
        G protein-coupled receptor signaling pathway 1393
          thrombin-activated receptor signaling pathway 13
            negative regulation of thrombin-activated receptor signaling pathway 3
            positive regulation of thrombin-activated receptor signaling pathway 0
            regulation of thrombin-activated receptor signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 19669
    biological regulation 13397
      regulation of biological process 13016
        signaling 7176
          signal transduction 6573
            G protein-coupled receptor signaling pathway 1393
              thrombin-activated receptor signaling pathway 13
                negative regulation of thrombin-activated receptor signaling pathway 3
                positive regulation of thrombin-activated receptor signaling pathway 0
                regulation of thrombin-activated receptor signaling pathway + 3
paths to the root