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ONTOLOGY REPORT - ANNOTATIONS


Term:thrombin-activated receptor signaling pathway
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Accession:GO:0070493 term browser browse the term
Definition:A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
Synonyms:exact_synonym: thrombin receptor signaling pathway;   thrombin receptor signalling pathway



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thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta involved_in ISO (PMID:15632189) RGD PMID:15632189 NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131
JBrowse link
G F2r coagulation factor II (thrombin) receptor involved_in
acts_upstream_of_or_within
IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
MGI:88380 (MGI:3810206|PMID:18398001)
Ensembl
UniProt
RGD
PMID:18398001 GO_REF:0000024 GO_REF:0000107 MGI:3810206 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098
JBrowse link
G F2rl3 F2R like thrombin or trypsin receptor 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase involved_in IEP PMID:19383433 UniProt PMID:19383433 RGD:8553438 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 involved_in ISO (PMID:12515716) RGD PMID:12515716 NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279
JBrowse link
G Plek pleckstrin involved_in ISO
IEA
(PMID:7782310)
GO_REF:0000107
(MGI:3844782|PMID:19190246)
RGD
Ensembl
PMID:7782310 PMID:19190246 GO_REF:0000107 MGI:3844782 NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131
JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Met MET proto-oncogene, receptor tyrosine kinase involved_in ISO
IEA
(PMID:25198505)
GO_REF:0000107
RGD
Ensembl
PMID:25198505 GO_REF:0000107 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:12239163) RGD PMID:12239163 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Stmn1 stathmin 1 involved_in ISO (PMID:25198505) RGD PMID:25198505 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    signaling 7370
      signal transduction 6808
        G protein-coupled receptor signaling pathway 2217
          thrombin-activated receptor signaling pathway 11
            negative regulation of thrombin-activated receptor signaling pathway 3
            positive regulation of thrombin-activated receptor signaling pathway 0
            regulation of thrombin-activated receptor signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 18734
    biological regulation 13314
      regulation of biological process 12594
        regulation of cellular process 11909
          signal transduction 6808
            G protein-coupled receptor signaling pathway 2217
              thrombin-activated receptor signaling pathway 11
                negative regulation of thrombin-activated receptor signaling pathway 3
                positive regulation of thrombin-activated receptor signaling pathway 0
                regulation of thrombin-activated receptor signaling pathway + 3
paths to the root