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ONTOLOGY REPORT - ANNOTATIONS


Term:ERK5 cascade
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Accession:GO:0070375 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Synonyms:exact_synonym: BMK cascade;   BMK signaling pathway;   BMK signalling pathway;   BMK1 cascade;   ERK5 signaling pathway;   MAPK7 cascade;   big MAP kinase signaling cascade;   extracellular signal-regulated kinase 5 cascade


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ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen-activated protein kinase kinase 5 ISO RGD PMID:15631999 RGD:1582263 NCBI chrNW_004936471:27,491,255...27,728,572 JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:11782488 RGD:2298794 NCBI chrNW_004936881:372,713...377,655 JBrowse link
G Mef2a myocyte enhancer factor 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:3,837,891...3,982,334 JBrowse link
negative regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk7 mitogen-activated protein kinase 7 acts_upstream_of_or_within ISO (MGI:1933463|PMID:11139578) MGI PMID:11139578 MGI:1933463 NCBI chrNW_004936881:372,713...377,655 JBrowse link
positive regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkal1 ALK and LTK ligand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936590:376,301...396,488 JBrowse link
G Alkal2 ALK and LTK ligand 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:146,648...154,475 JBrowse link
regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (MGI:6480257|PMID:26975711) MGI PMID:26975711 MGI:6480257 NCBI chrNW_004936750:107,689...122,679 JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:6480257|PMID:26975711) MGI
Ensembl
PMID:26975711 GO_REF:0000107 MGI:6480257 NCBI chrNW_004936717:233,696...380,963 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14984
    signaling 5706
      signal transduction 5235
        intracellular signal transduction 2332
          MAPK cascade 756
            ERK5 cascade 7
              negative regulation of ERK5 cascade 1
              positive regulation of ERK5 cascade 2
              regulation of ERK5 cascade + 5
Path 2
Term Annotations click to browse term
  biological_process 14984
    biological regulation 10729
      regulation of biological process 10178
        regulation of cellular process 9623
          signal transduction 5235
            intracellular signal transduction 2332
              MAPK cascade 756
                ERK5 cascade 7
                  negative regulation of ERK5 cascade 1
                  positive regulation of ERK5 cascade 2
                  regulation of ERK5 cascade + 5
paths to the root