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ONTOLOGY REPORT - ANNOTATIONS


Term:ERK5 cascade
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Accession:GO:0070375 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Synonyms:exact_synonym: BMK cascade;   BMK signaling pathway;   BMK signalling pathway;   BMK1 cascade;   ERK5 signaling pathway;   MAPK7 cascade;   big MAP kinase signaling cascade;   extracellular signal-regulated kinase 5 cascade



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ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen activated protein kinase kinase 5 IMP RGD PMID:15631999 RGD:1582263 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 IMP RGD PMID:11782488 RGD:2298794 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
JBrowse link
G Mef2a myocyte enhancer factor 2a involved_in ISO
IEA
ISS
(PMID:15132737)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15132737 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
JBrowse link
negative regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk7 mitogen-activated protein kinase 7 acts_upstream_of_or_within ISO (MGI:1933463|PMID:11139578) RGD PMID:11139578 MGI:1933463 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
JBrowse link
positive regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkal1 ALK and LTK ligand 1 involved_in ISO
IBA
(PMID:26418745)
PMID:21873635
RGD PMID:26418745 PMID:21873635 RGD:13792537 NCBI chr 5:13,019,729...13,049,913
Ensembl chr 5:13,019,429...13,049,948
JBrowse link
G Alkal2 ALK and LTK ligand 2 involved_in IBA
ISO
PMID:21873635
(PMID:26418745)
RGD PMID:26418745 PMID:21873635 RGD:13792537 NCBI chr 6:47,495,645...47,505,235
Ensembl chr 6:47,495,782...47,505,234
JBrowse link
regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (MGI:6480257|PMID:26975711) RGD PMID:26975711 MGI:6480257 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 acts_upstream_of_or_within ISO MGI:3613572 (MGI:6480257|PMID:26975711) RGD PMID:26975711 MGI:6480257 NCBI chr 2:227,500,366...227,645,243
Ensembl chr 2:227,500,367...227,645,169
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    signaling 7678
      signal transduction 7110
        intracellular signal transduction 2741
          MAPK cascade 856
            ERK5 cascade 7
              negative regulation of ERK5 cascade 1
              positive regulation of ERK5 cascade 2
              regulation of ERK5 cascade + 5
Path 2
Term Annotations click to browse term
  biological_process 20099
    biological regulation 13928
      regulation of biological process 13160
        regulation of cellular process 12438
          signal transduction 7110
            intracellular signal transduction 2741
              MAPK cascade 856
                ERK5 cascade 7
                  negative regulation of ERK5 cascade 1
                  positive regulation of ERK5 cascade 2
                  regulation of ERK5 cascade + 5
paths to the root