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ONTOLOGY REPORT - ANNOTATIONS


Term:ERK5 cascade
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Accession:GO:0070375 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Synonyms:exact_synonym: BMK cascade;   BMK signaling pathway;   BMK signalling pathway;   BMK1 cascade;   ERK5 signaling pathway;   MAPK7 cascade;   big MAP kinase signaling cascade;   extracellular signal-regulated kinase 5 cascade



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ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP2K5 mitogen-activated protein kinase kinase 5 ISO RGD PMID:15631999 RGD:1582263 NCBI chr 1:165,458,263...165,733,452
Ensembl chr 1:165,458,258...165,740,297
JBrowse link
G MAPK7 mitogen-activated protein kinase 7 ISO RGD PMID:11782488 RGD:2298794 NCBI chr12:60,144,138...60,148,743
Ensembl chr12:60,144,136...60,158,739
JBrowse link
G MEF2A myocyte enhancer factor 2A involved_in ISS
IEA
UniProt
UniProt
Ensembl
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 1:138,398,270...138,508,639
Ensembl chr 1:138,341,158...138,511,314
JBrowse link
negative regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK7 mitogen-activated protein kinase 7 acts_upstream_of_or_within ISO (MGI:1933463|PMID:11139578) MGI PMID:11139578 MGI:1933463 NCBI chr12:60,144,138...60,148,743
Ensembl chr12:60,144,136...60,158,739
JBrowse link
positive regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALKAL1 ALK and LTK ligand 1 involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 4:77,673,200...77,682,697
Ensembl chr 4:77,673,244...77,683,074
JBrowse link
G ALKAL2 ALK and LTK ligand 2 involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 3:132,661,153...132,671,270
Ensembl chr 3:132,660,909...132,670,124
JBrowse link
regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAC1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (MGI:6480257|PMID:26975711) MGI PMID:26975711 MGI:6480257 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543
JBrowse link
G RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:6480257|PMID:26975711) MGI
Ensembl
PMID:26975711 GO_REF:0000107 MGI:6480257 NCBI chr 8:121,866,803...122,007,492
Ensembl chr 8:121,866,805...122,082,948
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17339
    signaling 7090
      signal transduction 6540
        intracellular signal transduction 2691
          MAPK cascade 851
            ERK5 cascade 7
              negative regulation of ERK5 cascade 1
              positive regulation of ERK5 cascade 2
              regulation of ERK5 cascade + 5
Path 2
Term Annotations click to browse term
  biological_process 17339
    biological regulation 12837
      regulation of biological process 12201
        regulation of cellular process 11512
          signal transduction 6540
            intracellular signal transduction 2691
              MAPK cascade 851
                ERK5 cascade 7
                  negative regulation of ERK5 cascade 1
                  positive regulation of ERK5 cascade 2
                  regulation of ERK5 cascade + 5
paths to the root