Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:ERK5 cascade
go back to main search page
Accession:GO:0070375 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Synonyms:exact_synonym: BMK cascade;   BMK signaling pathway;   BMK signalling pathway;   BMK1 cascade;   ERK5 signaling pathway;   MAPK7 cascade;   big MAP kinase signaling cascade;   extracellular signal-regulated kinase 5 cascade



show annotations for term's descendants           Sort by:
 
ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen-activated protein kinase kinase 5 involved_in ISO RGD
MGI
PMID:15631999 GO_REF:0000096 MGI:4417868 RGD:1582263 NCBI chr 9:63,071,050...63,288,964
Ensembl chr 9:63,071,050...63,285,184
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 involved_in ISO RGD
MGI
PMID:11782488 GO_REF:0000096 MGI:4417868 RGD:2298794 NCBI chr11:61,379,638...61,385,101
Ensembl chr11:61,379,638...61,385,232
JBrowse link
G Mef2a myocyte enhancer factor 2A involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 7:66,880,911...67,026,435
Ensembl chr 7:66,880,911...67,022,606
JBrowse link
negative regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk7 mitogen-activated protein kinase 7 acts_upstream_of_or_within IDA (MGI:1933463|PMID:11139578) MGI PMID:11139578 MGI:1933463 NCBI chr11:61,379,638...61,385,101
Ensembl chr11:61,379,638...61,385,232
JBrowse link
positive regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkal1 ALK and LTK ligand 1 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 1:6,429,555...6,464,955
Ensembl chr 1:6,429,442...6,464,955
JBrowse link
G Alkal2 ALK and LTK ligand 2 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr12:30,934,323...30,943,855
Ensembl chr12:30,934,321...30,943,853
JBrowse link
regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within IDA (MGI:6480257|PMID:26975711) MGI PMID:26975711 MGI:6480257 NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791
JBrowse link
G Rap1gds1 RAP1, GTP-GDP dissociation stimulator 1 acts_upstream_of_or_within IMP (MGI:6480257|PMID:26975711) MGI PMID:26975711 MGI:6480257 NCBI chr 3:138,631,658...138,781,163
Ensembl chr 3:138,631,663...138,780,962
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28741
    signaling 7395
      signal transduction 6789
        intracellular signal transduction 2782
          MAPK cascade 883
            ERK5 cascade 7
              negative regulation of ERK5 cascade 1
              positive regulation of ERK5 cascade 2
              regulation of ERK5 cascade + 5
Path 2
Term Annotations click to browse term
  biological_process 28741
    biological regulation 13648
      regulation of biological process 12980
        regulation of cellular process 12227
          signal transduction 6789
            intracellular signal transduction 2782
              MAPK cascade 883
                ERK5 cascade 7
                  negative regulation of ERK5 cascade 1
                  positive regulation of ERK5 cascade 2
                  regulation of ERK5 cascade + 5
paths to the root