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ONTOLOGY REPORT - ANNOTATIONS


Term:ERK5 cascade
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Accession:GO:0070375 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Synonyms:exact_synonym: BMK cascade;   BMK signaling pathway;   BMK signalling pathway;   BMK1 cascade;   ERK5 signaling pathway;   MAPK7 cascade;   big MAP kinase signaling cascade;   extracellular signal-regulated kinase 5 cascade



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ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP2K5 mitogen-activated protein kinase kinase 5 ISO RGD PMID:15631999 RGD:1582263 NCBI chr30:31,665,032...31,920,792
Ensembl chr30:31,664,564...31,920,751
JBrowse link
G MAPK7 mitogen-activated protein kinase 7 ISO RGD PMID:11782488 RGD:2298794 NCBI chr 5:40,831,949...40,836,990
Ensembl chr 5:40,831,947...40,836,505
JBrowse link
G MEF2A myocyte enhancer factor 2A involved_in ISS UniProt GO_REF:0000024 NCBI chr 3:41,012,103...41,177,588
Ensembl chr 3:41,015,713...41,179,448
JBrowse link
negative regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK7 mitogen-activated protein kinase 7 acts_upstream_of_or_within ISO (MGI:1933463|PMID:11139578) MGI PMID:11139578 MGI:1933463 NCBI chr 5:40,831,949...40,836,990
Ensembl chr 5:40,831,947...40,836,505
JBrowse link
positive regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALKAL1 ALK and LTK ligand 1 involved_in ISO (PMID:26418745) UniProt PMID:26418745 NCBI chr29:4,375,877...4,395,708 JBrowse link
G ALKAL2 ALK and LTK ligand 2 involved_in ISO (PMID:26418745) UniProt PMID:26418745 NCBI chr17:269,433...274,035 JBrowse link
G RB1CC1 RB1 inducible coiled-coil 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr29:4,445,668...4,544,223
Ensembl chr29:4,375,785...4,517,168
JBrowse link
regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAC1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (MGI:6480257|PMID:26975711) MGI PMID:26975711 MGI:6480257 NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216
JBrowse link
G RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 acts_upstream_of_or_within ISO (MGI:6480257|PMID:26975711) MGI PMID:26975711 MGI:6480257 NCBI chr32:20,536,812...20,690,433
Ensembl chr32:20,534,699...20,688,950
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17242
    signaling 6593
      signal transduction 6042
        intracellular signal transduction 2684
          MAPK cascade 848
            ERK5 cascade 8
              negative regulation of ERK5 cascade 1
              positive regulation of ERK5 cascade 3
              regulation of ERK5 cascade + 6
Path 2
Term Annotations click to browse term
  biological_process 17242
    biological regulation 12426
      regulation of biological process 11765
        regulation of cellular process 11070
          signal transduction 6042
            intracellular signal transduction 2684
              MAPK cascade 848
                ERK5 cascade 8
                  negative regulation of ERK5 cascade 1
                  positive regulation of ERK5 cascade 3
                  regulation of ERK5 cascade + 6
paths to the root