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ONTOLOGY REPORT - ANNOTATIONS


Term:ERK5 cascade
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Accession:GO:0070375 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Synonyms:exact_synonym: BMK cascade;   BMK signaling pathway;   BMK signalling pathway;   BMK1 cascade;   ERK5 signaling pathway;   MAPK7 cascade;   big MAP kinase signaling cascade;   extracellular signal-regulated kinase 5 cascade



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ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP2K5 mitogen-activated protein kinase kinase 5 ISO RGD PMID:15631999 RGD:1582263 NCBI chr15:46,493,139...46,760,271
Ensembl chr15:64,761,394...65,029,655
JBrowse link
G MAPK7 mitogen-activated protein kinase 7 ISO RGD PMID:11782488 RGD:2298794 NCBI chr17:31,729,429...31,736,216
Ensembl chr17:36,894,146...36,899,969
JBrowse link
G MEF2A myocyte enhancer factor 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:78,246,439...78,396,720
Ensembl chr15:97,428,744...97,579,092
JBrowse link
negative regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK7 mitogen-activated protein kinase 7 acts_upstream_of_or_within ISO (MGI:1933463|PMID:11139578) MGI PMID:11139578 MGI:1933463 NCBI chr17:31,729,429...31,736,216
Ensembl chr17:36,894,146...36,899,969
JBrowse link
positive regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALKAL1 ALK and LTK ligand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,957,611...48,989,157
Ensembl chr 8:46,341,310...46,372,344
JBrowse link
G ALKAL2 ALK and LTK ligand 2 involved_in ISO (PMID:26418745) UniProt PMID:26418745 NCBI chr2A:272,597...281,725 JBrowse link
regulation of ERK5 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAC1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (MGI:6480257|PMID:26975711) MGI PMID:26975711 MGI:6480257 NCBI chr 7:7,039,379...7,068,866 JBrowse link
G RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:6480257|PMID:26975711) MGI
Ensembl
PMID:26975711 GO_REF:0000107 MGI:6480257 NCBI chr 4:90,671,891...90,846,501
Ensembl chr 4:101,336,286...101,510,517
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15365
    signaling 5454
      signal transduction 4978
        intracellular signal transduction 2382
          MAPK cascade 769
            ERK5 cascade 7
              negative regulation of ERK5 cascade 1
              positive regulation of ERK5 cascade 2
              regulation of ERK5 cascade + 5
Path 2
Term Annotations click to browse term
  biological_process 15365
    biological regulation 10992
      regulation of biological process 10398
        regulation of cellular process 9680
          signal transduction 4978
            intracellular signal transduction 2382
              MAPK cascade 769
                ERK5 cascade 7
                  negative regulation of ERK5 cascade 1
                  positive regulation of ERK5 cascade 2
                  regulation of ERK5 cascade + 5
paths to the root