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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of ERK1 and ERK2 cascade
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Accession:GO:0070373 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
Synonyms:exact_synonym: down regulation of ERK1 and ERK2 cascade;   downregulation of ERK1 and ERK2 cascade;   negative regulation of ERK1 and ERK2 signaling pathway;   negative regulation of ERK1 and ERK2 signalling pathway;   negative regulation of ERK1/2 cascade
 narrow_synonym: inhibition of ERK1 and ERK2 cascade;   negative regulation of ERK1 cascade;   negative regulation of ERK2 cascade;   negative regulation of MAPK1 cascade;   negative regulation of MAPK3 cascade
 broad_synonym: negative regulation of ERK cascade


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negative regulation of ERK1 and ERK2 cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO
IEA		 MGI:104738 (PMID:22729085)
GO_REF:0000107		 RGD
Ensembl		 PMID:22729085 GO_REF:0000107 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Ace2 angiotensin converting enzyme 2 IMP RGD PMID:20703229 RGD:9685431 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:12070119)		 UniProt
Ensembl
RGD		 PMID:12070119 GO_REF:0000024 GO_REF:0000107 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ankrd26 ankyrin repeat domain containing 26 acts_upstream_of_or_within ISO MGI:3774418 (PMID:21669876) RGD PMID:21669876 NCBI chr 4:151,670,604...151,740,032
Ensembl chr 4:151,672,037...151,739,968 		JBrowse link
G Arrb1 arrestin, beta 1 IMP RGD PMID:19254952 RGD:5509898 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Atf3 activating transcription factor 3 involved_in ISO
IEA		 (PMID:22053207)
GO_REF:0000107		 RGD
Ensembl		 PMID:22053207 GO_REF:0000107 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO
IEA		 (PMID:23589618)
GO_REF:0000107		 RGD
Ensembl		 PMID:23589618 GO_REF:0000107 NCBI chr17:42,048,842...42,060,650
Ensembl chr17:41,620,839...41,632,618 		JBrowse link
G C1ql4 complement C1q like 4 acts_upstream_of_or_within ISO
IEA		 (PMID:23449976)
GO_REF:0000107		 RGD
Ensembl		 PMID:23449976 GO_REF:0000107 NCBI chr 7:130,243,606...130,246,678
Ensembl chr 7:130,243,606...130,246,678 		JBrowse link
G C2h3orf33 similar to human chromosome 3 open reading frame 33 involved_in ISO
IEA		 (PMID:20680465)
GO_REF:0000107		 RGD
Ensembl		 PMID:20680465 GO_REF:0000107 NCBI chr 2:148,376,598...148,404,343
Ensembl chr 2:148,380,581...148,404,387 		JBrowse link
G Cav1 caveolin 1 IDA RGD PMID:20172952 RGD:6849300 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit IMP RGD PMID:20505147 RGD:8549538 NCBI chr 1:165,898,932...165,905,348
Ensembl chr 1:156,487,279...156,491,476 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IMP RGD PMID:20505147 RGD:8549538 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit IMP RGD PMID:20505147 RGD:8549538 NCBI chr14:42,588,948...42,595,669
Ensembl chr14:42,235,226...42,242,192 		JBrowse link
G Cnksr3 Cnksr family member 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19567370)		 UniProt
RGD		 PMID:19567370 GO_REF:0000024 NCBI chr 1:43,499,273...43,591,630
Ensembl chr 1:43,499,487...43,591,635 		JBrowse link
G Cryba1 crystallin, beta A1 IMP RGD PMID:21993393 RGD:10059647 NCBI chr10:62,608,373...62,614,726
Ensembl chr10:62,608,383...62,614,726 		JBrowse link
G Csk C-terminal Src kinase IDA RGD PMID:9325302 RGD:2303720 NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Dab2 DAB adaptor protein 2 involved_in IDA PMID:12473651 UniProt PMID:12473651 RGD:8553624 NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19903888)		 UniProt
Ensembl
RGD		 PMID:19903888 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:39,312,745...39,483,730
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 involved_in ISO
IEA		 (PMID:20551903)
GO_REF:0000107		 RGD
Ensembl		 PMID:20551903 GO_REF:0000107 NCBI chr11:82,416,853...82,607,797
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Dmd dystrophin acts_upstream_of_or_within ISO
IEA		 MGI:1856328 (PMID:14718391)
GO_REF:0000107		 RGD
Ensembl		 PMID:14718391 GO_REF:0000107 NCBI chr  X:51,070,098...53,437,845
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Dusp1 dual specificity phosphatase 1 IMP RGD PMID:17437549 RGD:7771545 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in ISO
IEA		 (PMID:25772234)
GO_REF:0000107		 RGD
Ensembl		 PMID:25772234 GO_REF:0000107 NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp26 dual specificity phosphatase 26 involved_in ISO
IEA		 (PMID:16581800)
GO_REF:0000107		 RGD
Ensembl		 PMID:16581800 GO_REF:0000107 NCBI chr16:61,041,784...61,049,319
Ensembl chr16:61,041,792...61,049,051 		JBrowse link
G Dusp29 dual specificity phosphatase 29 involved_in ISS
ISO		 GO_REF:0000024
(PMID:32639872)		 UniProt
RGD		 PMID:32639872 GO_REF:0000024 NCBI chr15:2,593,473...2,634,019
Ensembl chr15:2,593,578...2,633,503 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in ISO
IBA		 (PMID:11085983)
GO_REF:0000033		 RGD
GO_Central		 PMID:11085983 GO_REF:0000033 NCBI chr10:87,420,213...87,434,202
Ensembl chr10:86,920,014...86,933,962 		JBrowse link
G Dusp4 dual specificity phosphatase 4 involved_in ISO
ISS		 (PMID:7535768)
GO_REF:0000024		 RGD
UniProt		 PMID:7535768 GO_REF:0000024 NCBI chr16:64,079,893...64,101,396
Ensembl chr16:57,377,229...57,398,138 		JBrowse link
G Dusp6 dual specificity phosphatase 6 involved_in IDA
IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:18771677)		 Ensembl
GO_Central
RGD		 PMID:18771677 PMID:8626780 GO_REF:0000033 GO_REF:0000107, RGD:728656 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Dusp7 dual specificity phosphatase 7 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:115,888,091...115,895,126
Ensembl chr 8:107,008,528...107,016,404 		JBrowse link
G Dusp9 dual specificity phosphatase 9 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:151,351,897...151,355,822
Ensembl chr  X:151,351,897...151,355,821 		JBrowse link
G Dynlt1 dynein light chain Tctex-type 1 acts_upstream_of_or_within ISO (PMID:22028875) RGD PMID:22028875 NCBI chr 1:49,292,093...49,299,051
Ensembl chr 1:46,887,017...46,893,881 		JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A IMP RGD PMID:22025682 RGD:10755441 NCBI chr 1:269,888,730...269,925,785
Ensembl chr 1:259,902,680...259,932,976 		JBrowse link
G Emilin1 elastin microfibril interfacer 1 involved_in ISO
IEA		 (PMID:25056700)
GO_REF:0000107		 RGD
Ensembl		 PMID:25056700 GO_REF:0000107 NCBI chr 6:31,175,919...31,183,657
Ensembl chr 6:25,445,298...25,463,698 		JBrowse link
G Epha4 Eph receptor A4 involved_in ISO
IEA		 (PMID:29093007)
GO_REF:0000107		 RGD
Ensembl		 PMID:29093007 GO_REF:0000107 NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Ephb2 Eph receptor B2 involved_in ISO
IEA		 (PMID:11585923)
GO_REF:0000107		 RGD
Ensembl		 PMID:11585923 GO_REF:0000107 NCBI chr 5:154,179,065...154,360,459
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Ezr ezrin involved_in ISO
IEA		 (PMID:20551903)
GO_REF:0000107		 RGD
Ensembl		 PMID:20551903 GO_REF:0000107 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Fbln1 fibulin 1 involved_in ISO
IEA		 (PMID:11792823)
GO_REF:0000107		 RGD
Ensembl		 PMID:11792823 GO_REF:0000107 NCBI chr 7:118,190,347...118,269,965
Ensembl chr 7:116,310,582...116,390,075 		JBrowse link
G Flcn folliculin involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
MGI:3774414|MGI:4348628 (PMID:18182616), (PMID:21258407)		 UniProt
Ensembl
RGD		 PMID:18182616 PMID:21258407 GO_REF:0000024 GO_REF:0000107 NCBI chr10:45,088,164...45,107,581
Ensembl chr10:44,588,624...44,607,769 		JBrowse link
G Gbp1 guanylate binding protein 1 involved_in ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in ISO (PMID:23840305) RGD PMID:23840305 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:16023107)
(PMID:11408560)		 BHF-UCL
Ensembl
RGD		 PMID:11408560 PMID:16023107 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within ISO MGI:96787 (PMID:16691571) RGD PMID:16691571 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 involved_in ISO (PMID:20616313) RGD PMID:20616313 NCBI chr 6:46,549,994...46,564,735
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Klf4 KLF transcription factor 4 involved_in IMP PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Lif LIF, interleukin 6 family cytokine acts_upstream_of_or_within ISO MGI:96432 (PMID:16691571) RGD PMID:16691571 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Lmo3 LIM domain only 3 involved_in ISO
IEA		 (PMID:23823477)
GO_REF:0000107		 RGD
Ensembl		 PMID:23823477 GO_REF:0000107 NCBI chr 4:172,965,944...173,028,980
Ensembl chr 4:171,234,696...171,292,222 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:14525964), (PMID:14726379)		 UniProt
Ensembl
RGD		 PMID:14525964 PMID:14726379 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Mir138-1 microRNA 138-1 acts_upstream_of ISO (PMID:21444814) RGD PMID:21444814 NCBI chr 8:131,178,434...131,178,532
Ensembl chr 8:122,300,966...122,301,064 		JBrowse link
G Mir138-2 microRNA 138-2 acts_upstream_of ISO (PMID:21444814) RGD PMID:21444814 NCBI chr19:10,680,133...10,680,214
Ensembl chr19:10,674,193...10,674,274 		JBrowse link
G Mir17 microRNA 17 IMP RGD PMID:29536180 RGD:329403057 NCBI chr15:98,587,848...98,587,931
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir185 microRNA 185 involved_in ISO (PMID:28277742) RGD PMID:28277742 NCBI chr11:96,169,028...96,169,107
Ensembl chr11:82,664,716...82,664,795 		JBrowse link
G Mir200c microRNA 200c acts_upstream_of ISO (PMID:24205206) RGD PMID:24205206 NCBI chr 4:159,209,965...159,210,033 JBrowse link
G Mir205 microRNA 205 acts_upstream_of ISO (PMID:23974361) RGD PMID:23974361 NCBI chr13:107,564,535...107,564,642
Ensembl chr13:105,035,878...105,035,985 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:20483747) RGD PMID:20483747 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir221 microRNA 221 involved_in ISO (PMID:23333386) RGD PMID:23333386 NCBI chr  X:6,023,182...6,023,290
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir322 microRNA 322 involved_in ISO RNAcentral:URS00000F6E49_9606 (PMID:23263626) RGD PMID:23263626 NCBI chr  X:137,726,147...137,726,241
Ensembl chr  X:132,806,594...132,806,688 		JBrowse link
G Mir503 microRNA 503 involved_in ISO RNAcentral:URS00000F0F49_9606 (PMID:23263626) RGD PMID:23263626 NCBI chr  X:137,725,856...137,725,926
Ensembl chr  X:132,806,303...132,806,373 		JBrowse link
G Ndrg2 NDRG family member 2 acts_upstream_of_or_within ISO
IEA		 (PMID:19815093)
GO_REF:0000107		 RGD
Ensembl		 PMID:19815093 GO_REF:0000107 NCBI chr15:27,074,481...27,087,376
Ensembl chr15:24,600,982...24,609,626 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 involved_in ISO (PMID:20012548) RGD PMID:20012548 NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,403,069...100,420,598 		JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 acts_upstream_of_or_within ISO
IEA		 MGI:4836357 (PMID:22503542)
GO_REF:0000107		 RGD
Ensembl		 PMID:22503542 GO_REF:0000107 NCBI chr 1:74,848,020...74,885,945
Ensembl chr 1:65,932,595...65,960,934 		JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22763455)		 Ensembl
RGD		 PMID:22763455 GO_REF:0000107 NCBI chr 1:205,434,484...205,441,245
Ensembl chr 1:196,004,953...196,011,113 		JBrowse link
G Phb1 prohibitin 1 involved_in ISO (PMID:24732013) RGD PMID:24732013 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:20179103) RGD PMID:20179103 NCBI chr 8:27,465,538...27,477,016
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Psca prostate stem cell antigen involved_in ISO (PMID:25680266) RGD PMID:25680266 NCBI chr 7:108,483,974...108,492,098
Ensembl chr 7:106,595,284...106,609,746 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
UniProtKB:P97333 (PMID:23639442)		 GO_Central
Ensembl
RGD		 PMID:23639442 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:15696169)
GO_REF:0000033
GO_REF:0000107		 UniProt
RGD
GO_Central
Ensembl		 PMID:15696169 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISO UniProtKB:P06240 (PMID:15661907) RGD PMID:15661907 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R involved_in IEA
ISO		 GO_REF:0000107
(PMID:21724833)		 Ensembl
RGD		 PMID:21724833 GO_REF:0000107 NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603 		JBrowse link
G Ranbp9 RAN binding protein 9 involved_in ISO
IEA		 (PMID:23118896)
GO_REF:0000107		 RGD
Ensembl		 PMID:23118896 GO_REF:0000107 NCBI chr17:21,220,807...21,303,009
Ensembl chr17:21,220,618...21,303,004 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO
IEA		 MGI:95516 (PMID:16858399)
GO_REF:0000107		 RGD
Ensembl		 PMID:16858399 GO_REF:0000107 NCBI chr 3:33,296,211...33,414,119
Ensembl chr 3:12,898,266...13,013,984 		JBrowse link
G Rgs14 regulator of G-protein signaling 14 involved_in IDA PMID:19878719 UniProt PMID:19878719 RGD:8553779 NCBI chr17:9,254,112...9,268,233
Ensembl chr17:9,249,019...9,263,104 		JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 involved_in ISO (PMID:15121846) RGD PMID:15121846 NCBI chr  X:76,353,316...76,454,502
Ensembl chr  X:76,353,760...76,454,484 		JBrowse link
G Sema6a semaphorin 6A involved_in ISO
IEA		 (PMID:21536891)
GO_REF:0000107		 RGD
Ensembl		 PMID:21536891 GO_REF:0000107 NCBI chr18:42,237,227...42,358,540
Ensembl chr18:40,050,624...40,171,954 		JBrowse link
G Sirpa signal-regulatory protein alpha involved_in ISO (PMID:17954568) RGD PMID:17954568 NCBI chr 3:137,272,932...137,311,279
Ensembl chr 3:116,819,726...116,858,098 		JBrowse link
G Sirt3 sirtuin 3 IMP RGD PMID:23397292 RGD:9586042 NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16151019)		 Ensembl
RGD		 PMID:16151019 GO_REF:0000107 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Spred1 sprouty-related, EVH1 domain containing 1 involved_in ISO
IEA		 (PMID:26934179), (PMID:29501879)
GO_REF:0000107		 RGD
Ensembl		 PMID:26934179 PMID:29501879 GO_REF:0000107 NCBI chr 3:124,437,230...124,504,358
Ensembl chr 3:103,983,072...104,049,718 		JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:29501879)		 UniProt
GO_Central
RGD		 PMID:29501879 GO_REF:0000024 GO_REF:0000033 NCBI chr14:98,350,577...98,452,143
Ensembl chr14:94,148,837...94,249,162 		JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 involved_in ISO
IBA		 (PMID:29501879)
GO_REF:0000033		 RGD
GO_Central		 PMID:29501879 GO_REF:0000033 NCBI chr 1:93,586,259...93,597,692
Ensembl chr 1:84,459,314...84,470,249 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 MGI:1099809|MGI:1345138 (PMID:11585837), (PMID:21764747)
GO_REF:0000107
GO_REF:0000033
(PMID:19043405), (PMID:29501879)		 RGD
Ensembl
GO_Central		 PMID:11585837 PMID:19043405 PMID:21764747 PMID:29501879 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:120,556,706...120,566,189 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:20489163), (PMID:21536891)
GO_REF:0000107
GO_REF:0000033
(PMID:18508928), (PMID:29501879)
MGI:1099809|MGI:1345139 (PMID:11585837), (PMID:21764747)		 RGD
Ensembl
GO_Central		 PMID:11585837 PMID:18508928 PMID:20489163 PMID:21536891 PMID:21764747 More... GO_REF:0000033 GO_REF:0000107 NCBI chr15:89,106,809...89,111,926
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
G Spry3 sprouty RTK signaling antagonist 3 involved_in ISO
IBA		 (PMID:16877379)
GO_REF:0000033		 RGD
GO_Central		 PMID:16877379 GO_REF:0000033 NCBI chr12:16,663,188...16,673,124
Ensembl chr12:16,663,389...16,672,531 		JBrowse link
G Spry3-ps1 sprouty RTK signaling antagonist 3, pseudogene 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:35,158,365...35,158,967
Ensembl chr 1:35,158,365...35,158,913 		JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:30,687,633...30,702,546
Ensembl chr18:30,436,443...30,453,004 		JBrowse link
G Synj2bp synaptojanin 2 binding protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:24025447)		 UniProt
RGD		 PMID:24025447 GO_REF:0000024 NCBI chr 6:106,920,970...106,958,653
Ensembl chr 6:101,189,714...101,227,406 		JBrowse link
G Tbc1d10c TBC1 domain family, member 10C acts_upstream_of_or_within ISO
IEA		 MGI:1932389 (PMID:23109291)
GO_REF:0000107		 RGD
Ensembl		 PMID:23109291 GO_REF:0000107 NCBI chr 1:210,906,621...210,913,649
Ensembl chr 1:201,477,157...201,564,920 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:20051628)		 Ensembl
RGD		 PMID:20051628 GO_REF:0000107 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr9 toll-like receptor 9 acts_upstream_of_or_within ISO
IEA		 MGI:1922072 (PMID:23109291)
GO_REF:0000107		 RGD
Ensembl		 PMID:23109291 GO_REF:0000107 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 involved_in ISO
IBA		 (PMID:12220502)
GO_REF:0000033		 RGD
GO_Central		 PMID:12220502 GO_REF:0000033 NCBI chr10:39,537,759...39,585,038
Ensembl chr10:39,037,058...39,077,625 		JBrowse link
G Vrk3 VRK serine/threonine kinase 3 acts_upstream_of_or_within ISO
IEA		 (PMID:18035061)
GO_REF:0000107		 RGD
Ensembl		 PMID:18035061 GO_REF:0000107 NCBI chr 1:104,379,903...104,407,278
Ensembl chr 1:95,243,364...95,270,780 		JBrowse link
G Wnk2 WNK lysine deficient protein kinase 2 involved_in ISO (PMID:17667937) RGD PMID:17667937 NCBI chr17:15,503,672...15,612,479
Ensembl chr17:15,504,261...15,612,479 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:26315405) RGD PMID:26315405 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      signal transduction 7301
        intracellular signal transduction 3189
          negative regulation of intracellular signal transduction 807
            negative regulation of MAPK cascade 203
              negative regulation of ERK1 and ERK2 cascade 92
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        signaling 7862
          signal transduction 7301
            intracellular signal transduction 3189
              intracellular signaling cassette 2051
                MAPK cascade 872
                  regulation of MAPK cascade 776
                    regulation of ERK1 and ERK2 cascade 337
                      negative regulation of ERK1 and ERK2 cascade 92
paths to the root