Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:hepatocyte differentiation
go back to main search page
Accession:GO:0070365 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.
Synonyms:exact_synonym: liver cell differentiation



show annotations for term's descendants           Sort by:
 
hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEP
IBA
PMID:21873635 RGD
GO_Central
PMID:11668598 PMID:21873635 RGD:2306909, RGD:13792537 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 IEP RGD PMID:12939595 RGD:4144098 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP RGD PMID:17574236 RGD:2306655 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G E2f7 E2F transcription factor 7 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:5449497|PMID:23064266)
UniProt
Ensembl
RGD
PMID:23064266 GO_REF:0000024 GO_REF:0000107 MGI:5449497 NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
JBrowse link
G E2f8 E2F transcription factor 8 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5449497|PMID:23064266), (MGI:5449498|PMID:23064264)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:23064264 PMID:23064266 GO_REF:0000024 GO_REF:0000107 MGI:5449497 MGI:5449498 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
JBrowse link
G Frzb frizzled-related protein acts_upstream_of
involved_in
ISO
IEA
(MGI:4356222|PMID:19562671)
GO_REF:0000107
RGD
Ensembl
PMID:19562671 GO_REF:0000107 MGI:4356222 NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 IEP RGD PMID:10934156 RGD:14701049 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Hhex hematopoietically expressed homeobox acts_upstream_of_or_within ISO MGI:2448661 (MGI:1891782|PMID:11027604) RGD PMID:11027604 MGI:1891782 NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
JBrowse link
G Hnf1b HNF1 homeobox B IEP RGD PMID:18286537 RGD:2312718 NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha involved_in IEP
IEA
GO_REF:0000002 InterPro
RGD
PMID:19621519 GO_REF:0000002, RGD:12904750 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Itga2 integrin subunit alpha 2 IEP RGD PMID:16458388 RGD:2307397 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Krt18 keratin 18 IEP RGD PMID:24340101 PMID:28941653 RGD:27226712, RGD:27226713 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
JBrowse link
G Prox1 prospero homeobox 1 involved_in
acts_upstream_of_or_within
ISO (PMID:15232737) RGD PMID:15232737 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 acts_upstream_of_or_within ISO MGI:2387974 (MGI:3610866|PMID:16138077) RGD PMID:16138077 MGI:3610866 NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
JBrowse link
G Taf10 TATA-box binding protein associated factor 10 acts_upstream_of_or_within ISO MGI:2176946|MGI:3606185 (MGI:3806427|PMID:18722179) RGD PMID:18722179 MGI:3806427 NCBI chr 1:160,095,108...160,096,401
Ensembl chr 1:160,095,108...160,096,376
JBrowse link
G Wnt1 Wnt family member 1 IMP RGD PMID:20413689 RGD:2326223 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
negative regulation of hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Frzb frizzled-related protein acts_upstream_of_or_within ISO (MGI:4356222|PMID:19562671) RGD PMID:19562671 MGI:4356222 NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208
JBrowse link
positive regulation of hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IMP RGD PMID:19229878 RGD:8885195 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Foxa3 forkhead box A3 IMP RGD PMID:9878541 RGD:2315086 NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    cellular process 17430
      cellular developmental process 4532
        cell differentiation 4509
          epithelial cell differentiation 795
            hepatocyte differentiation 21
              negative regulation of hepatocyte differentiation 1
              positive regulation of hepatocyte differentiation 3
              regulation of hepatocyte differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 18737
    developmental process 6895
      anatomical structure development 6371
        multicellular organism development 5436
          system development 4939
            hepaticobiliary system development 272
              liver development 269
                hepatocyte differentiation 21
                  negative regulation of hepatocyte differentiation 1
                  positive regulation of hepatocyte differentiation 3
                  regulation of hepatocyte differentiation + 4
paths to the root