Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:lens fiber cell differentiation
go back to main search page
Accession:GO:0070306 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.
Synonyms:exact_synonym: lens fibre cell differentiation


show annotations for term's descendants           Sort by:
lens fiber cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crygd crystallin, gamma D acts_upstream_of_or_within
involved_in		 IDA
ISO
IEA		 MGI:3762620 (PMID:17652744)
GO_REF:0000107		 RGD
Ensembl		 PMID:17652744 PMID:8575616 GO_REF:0000107, RGD:1601018 NCBI chr 9:66,442,057...66,443,668
Ensembl chr 9:66,442,054...66,444,067 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 acts_upstream_of_or_within ISO (PMID:17215516) RGD PMID:17215516 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952 		JBrowse link
G Kdm5b lysine demethylase 5B IEP RGD PMID:24142921 RGD:9587771 NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872 		JBrowse link
G Maf MAF bZIP transcription factor involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:2148636|MGI:2148637 (PMID:10383433), (PMID:12835653)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:10383433 PMID:12835653 GO_REF:0000033 GO_REF:0000107 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365 		JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor involved_in IEA
ISO		 GO_REF:0000107
(PMID:20181838)		 Ensembl
RGD		 PMID:20181838 GO_REF:0000107 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 acts_upstream_of_or_within ISO MGI:1100860 (PMID:23136392) RGD PMID:23136392 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Pitx3 paired-like homeodomain 3 involved_in ISO (PMID:19007884) RGD PMID:19007884 NCBI chr 1:245,001,106...245,013,881
Ensembl chr 1:245,001,164...245,013,892 		JBrowse link
G Plaat1 phospholipase A and acyltransferase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr11:71,517,492...71,537,142
Ensembl chr11:71,517,493...71,527,020 		JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:33854238)		 UniProt
RGD		 PMID:33854238 GO_REF:0000024 NCBI chr 1:204,782,608...204,816,397
Ensembl chr 1:204,782,729...204,817,667 		JBrowse link
G Six3 SIX homeobox 3 involved_in ISO (PMID:12072567) RGD PMID:12072567 NCBI chr 6:9,039,017...9,043,336
Ensembl chr 6:9,036,434...9,053,301 		JBrowse link
G Skil SKI-like proto-oncogene acts_upstream_of_or_within ISO (PMID:17215516) RGD PMID:17215516 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 IEP RGD PMID:16043861 RGD:2315033 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Smad3 SMAD family member 3 acts_upstream_of_or_within ISO (PMID:17215516) RGD PMID:17215516 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tdrd7 tudor domain containing 7 involved_in ISO
IBA
IEA
ISS		 (PMID:21436445)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:21436445 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:60,238,742...60,312,548
Ensembl chr 5:60,238,678...60,312,544 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO (PMID:17215516) RGD PMID:17215516 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
lens fiber cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfsp1 beaded filament structural protein 1 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:15037121)		 Ensembl
GO_Central
RGD		 PMID:15037121 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:131,195,087...131,252,668
Ensembl chr 3:131,195,087...131,229,337 		JBrowse link
G Bfsp2 beaded filament structural protein 2 acts_upstream_of_or_within ISO MGI:2671074 (PMID:15037121), (PMID:17065509) RGD PMID:15037121 PMID:17065509 NCBI chr 8:104,006,226...104,063,399
Ensembl chr 8:104,006,226...104,063,399 		JBrowse link
G Crygb crystallin, gamma B acts_upstream_of_or_within ISO MGI:3777015 (PMID:18172107) RGD PMID:18172107 NCBI chr 9:66,461,460...66,463,520
Ensembl chr 9:66,461,460...66,463,520 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:3044679|MGI:3045749|MGI:95524 (PMID:18455718), (PMID:23136392) RGD PMID:18455718 PMID:23136392 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO MGI:95523 (PMID:18455718) RGD PMID:18455718 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 acts_upstream_of_or_within ISO MGI:3045749|MGI:3768912|MGI:97385 (PMID:23136392) RGD PMID:23136392 NCBI chr 7:52,711,255...52,792,738
Ensembl chr 7:52,711,257...52,792,743 		JBrowse link
G Smarca4 SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 acts_upstream_of_or_within ISO MGI:2386105 (PMID:21118511) RGD PMID:21118511 NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975 		JBrowse link
G Tmod1 tropomodulin 1 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q6NVD9 (PMID:23144950)		 Ensembl
RGD		 PMID:23144950 GO_REF:0000107 NCBI chr 5:60,316,445...60,393,957
Ensembl chr 5:60,338,512...60,393,956 		JBrowse link
G Vim vimentin involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:15037121)		 Ensembl
RGD		 PMID:15037121 GO_REF:0000107 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
lens fiber cell morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 involved_in ISO (PMID:15572692) RGD PMID:15572692 NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:61,827,139...61,905,699 		JBrowse link
G Atf4 activating transcription factor 4 involved_in ISS
ISO		 GO_REF:0000024
(PMID:10096021), (PMID:10885750), (PMID:11806972)		 UniProt
RGD		 PMID:10096021 PMID:10885750 PMID:11806972 GO_REF:0000024 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Cryaa crystallin, alpha A acts_upstream_of_or_within ISO MGI:3665275|MGI:3777403 (PMID:16799046), (PMID:18056999) RGD PMID:16799046 PMID:18056999 NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349 		JBrowse link
G Crygb crystallin, gamma B acts_upstream_of_or_within ISO MGI:1857597 (PMID:12426373), (PMID:8626090) RGD PMID:8626090 PMID:12426373 NCBI chr 9:66,461,460...66,463,520
Ensembl chr 9:66,461,460...66,463,520 		JBrowse link
G Epha2 Eph receptor A2 involved_in ISO (PMID:18948590) RGD PMID:18948590 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117 		JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:11850194)
(PMID:10080188)		 RGD PMID:10080188 PMID:11850194 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
G Tbc1d20 TBC1 domain family, member 20 acts_upstream_of_or_within ISO MGI:1856684 (PMID:24239381) RGD PMID:24239381 NCBI chr 3:140,768,537...140,787,010
Ensembl chr 3:140,768,537...140,785,121 		JBrowse link
negative regulation of lens fiber cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxe3 forkhead box E3 involved_in ISS
ISO		 PMID:16199865
(PMID:10652278), (PMID:10890982), (PMID:16199865)		 RGD PMID:10652278 PMID:10890982 PMID:16199865 PMID:16199865 RGD:10047273 NCBI chr 5:128,444,912...128,446,494
Ensembl chr 5:128,445,594...128,446,454 		JBrowse link
G Spred1 sprouty-related, EVH1 domain containing 1 involved_in ISO (PMID:29501879) RGD PMID:29501879 NCBI chr 3:103,983,120...104,050,321
Ensembl chr 3:103,983,072...104,049,718 		JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29501879)		 UniProt
RGD		 PMID:29501879 GO_REF:0000024 NCBI chr14:94,149,210...94,250,787
Ensembl chr14:94,148,837...94,249,162 		JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 involved_in ISO (PMID:29501879) RGD PMID:29501879 NCBI chr 1:84,458,779...84,470,425
Ensembl chr 1:84,459,314...84,470,249 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 involved_in ISO (PMID:29501879) RGD PMID:29501879 NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in ISO (PMID:29501879) RGD PMID:29501879 NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
positive regulation of lens fiber cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29501879)		 UniProt
RGD		 PMID:29501879 GO_REF:0000024 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 involved_in ISO (PMID:16162653) RGD PMID:16162653 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
regulation of lens fiber cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B acts_upstream_of_or_within ISO MGI:104564 (PMID:9784491) RGD PMID:9784491 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C acts_upstream_of_or_within ISO MGI:104565 (PMID:9784491) RGD PMID:9784491 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    developmental process 7070
      anatomical structure development 6573
        lens development in camera-type eye 97
          lens fiber cell differentiation 40
            lens fiber cell development + 15
            lens fiber cell fate commitment 0
            negative regulation of lens fiber cell differentiation 6
            positive regulation of lens fiber cell differentiation 2
            regulation of lens fiber cell differentiation + 10
Path 2
Term Annotations click to browse term
  biological_process 20076
    developmental process 7070
      anatomical structure development 6573
        multicellular organism development 5299
          system development 4584
            sensory system development 505
              visual system development 498
                eye development 495
                  camera-type eye development 443
                    lens development in camera-type eye 97
                      lens fiber cell differentiation 40
                        lens fiber cell development + 15
                        lens fiber cell fate commitment 0
                        negative regulation of lens fiber cell differentiation 6
                        positive regulation of lens fiber cell differentiation 2
                        regulation of lens fiber cell differentiation + 10
paths to the root