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ONTOLOGY REPORT - ANNOTATIONS


Term:lens fiber cell differentiation
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Accession:GO:0070306 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.
Synonyms:exact_synonym: lens fibre cell differentiation


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lens fiber cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crygd crystallin, gamma D IDA
ISO
MGI:3762620 (MGI:3762268|PMID:17652744) RGD PMID:17652744, PMID:8575616 MGI:3762268, RGD:1601018 NCBI chr 9:71,776,568...71,778,323
Ensembl chr 9:71,764,318...71,778,323
JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 ISO (MGI:3720408|PMID:17215516) RGD PMID:17215516 MGI:3720408 NCBI chr 7:11,201,690...11,213,614
Ensembl chr 7:11,201,690...11,213,613
JBrowse link
G Kdm5b lysine demethylase 5B IEP RGD PMID:24142921 RGD:9587771 NCBI chr13:51,384,371...51,455,392
Ensembl chr13:51,384,389...51,455,357
JBrowse link
G Maf MAF bZIP transcription factor involved_in ISO
IEA
IBA
MGI:2148636|MGI:2148637 (MGI:1340085|PMID:10383433), (MGI:3760711|PMID:12835653)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:10383433 PMID:12835653, PMID:21873635 GO_REF:0000107 MGI:1340085 MGI:3760711, RGD:13792537 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Nf2 neurofibromin 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:4457460|PMID:20181838)
Ensembl
RGD
PMID:20181838 GO_REF:0000107 MGI:4457460 NCBI chr14:84,996,905...85,088,547
Ensembl chr14:84,996,905...85,088,523
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 ISO MGI:1100860 (MGI:5447585|PMID:23136392) RGD PMID:23136392 MGI:5447585 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Pitx3 paired-like homeodomain 3 ISO (MGI:3831639|PMID:19007884) RGD PMID:19007884 MGI:3831639 NCBI chr 1:265,886,766...265,899,947
Ensembl chr 1:265,887,230...265,899,958
JBrowse link
G Six3 SIX homeobox 3 ISO (MGI:2181466|PMID:12072567) RGD PMID:12072567 MGI:2181466 NCBI chr 6:8,886,730...8,891,094
Ensembl chr 6:8,886,591...8,889,925
JBrowse link
G Skil SKI-like proto-oncogene ISO (MGI:3720408|PMID:17215516) RGD PMID:17215516 MGI:3720408 NCBI chr 2:115,862,932...115,891,304
Ensembl chr 2:115,866,701...115,891,097
JBrowse link
G Slc7a11 solute carrier family 7 member 11 IEP RGD PMID:16043861 RGD:2315033 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Smad3 SMAD family member 3 ISO (MGI:3720408|PMID:17215516) RGD PMID:17215516 MGI:3720408 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Tdrd7 tudor domain containing 7 involved_in ISO
ISS
(PMID:21436445)
GO_REF:0000024
(MGI:4943339|PMID:21436445)
RGD
UniProt
PMID:21436445 GO_REF:0000024 MGI:4943339 NCBI chr 5:61,557,909...61,631,719
Ensembl chr 5:61,564,864...61,631,710
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO (MGI:3720408|PMID:17215516) RGD PMID:17215516 MGI:3720408 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
lens fiber cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfsp1 beaded filament structural protein 1 involved_in IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(MGI:2673300|PMID:15037121)
Ensembl
RGD
PMID:15037121, PMID:21873635, PMID:21873635 GO_REF:0000107 MGI:2673300, RGD:13792537, RGD:13792537 NCBI chr 3:137,935,345...137,992,652
Ensembl chr 3:137,935,345...137,969,658
JBrowse link
G Bfsp2 beaded filament structural protein 2 ISO MGI:2671074 (MGI:2673300|PMID:15037121), (MGI:3717045|PMID:17065509) RGD PMID:15037121 PMID:17065509 MGI:2673300 MGI:3717045 NCBI chr 8:111,908,614...111,965,889
Ensembl chr 8:111,908,614...111,965,889
JBrowse link
G Crygb crystallin, gamma B ISO MGI:3777015 (MGI:3776178|PMID:18172107) RGD PMID:18172107 MGI:3776178 NCBI chr 9:71,796,204...71,798,265
Ensembl chr 9:71,796,204...71,798,265
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISO MGI:3044679|MGI:3045749|MGI:95524 (MGI:3796810|PMID:18455718), (MGI:5447585|PMID:23136392) RGD PMID:18455718 PMID:23136392 MGI:3796810 MGI:5447585 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO MGI:95523 (MGI:3796810|PMID:18455718) RGD PMID:18455718 MGI:3796810 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 ISO MGI:3045749|MGI:3768912|MGI:97385 (MGI:5447585|PMID:23136392) RGD PMID:23136392 MGI:5447585 NCBI chr 7:60,128,506...60,210,482
Ensembl chr 7:60,128,508...60,210,518
JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 ISO MGI:2386105 (MGI:4888440|PMID:21118511) RGD PMID:21118511 MGI:4888440 NCBI chr 8:22,648,323...22,739,468
Ensembl chr 8:22,648,323...22,739,468
JBrowse link
G Tmod1 tropomodulin 1 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:Q6NVD9 (MGI:5475090|PMID:23144950)
Ensembl
RGD
PMID:23144950 GO_REF:0000107 MGI:5475090 NCBI chr 5:61,635,244...61,712,052
Ensembl chr 5:61,657,507...61,712,051
JBrowse link
G Vim vimentin involved_in IEA
ISO
GO_REF:0000107
(MGI:2673300|PMID:15037121)
Ensembl
RGD
PMID:15037121 GO_REF:0000107 MGI:2673300 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
lens fiber cell morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 ISO (MGI:3525751|PMID:15572692) RGD PMID:15572692 MGI:3525751 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
JBrowse link
G Atf4 activating transcription factor 4 involved_in ISS
ISO
GO_REF:0000024
(MGI:1339872|PMID:10096021), (MGI:1859108|PMID:10885750), (MGI:2158533|PMID:11806972)
UniProt
RGD
PMID:10096021 PMID:10885750 PMID:11806972 GO_REF:0000024 MGI:1339872 MGI:1859108 MGI:2158533 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Cryaa crystallin, alpha A ISO MGI:3665275|MGI:3777403 (MGI:3655912|PMID:16799046), (MGI:3775669|PMID:18056999) RGD PMID:16799046 PMID:18056999 MGI:3655912 MGI:3775669 NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187
JBrowse link
G Crygb crystallin, gamma B ISO MGI:1857597 (MGI:3691890|PMID:12426373), (MGI:81294|PMID:8626090) RGD PMID:8626090 PMID:12426373 MGI:3691890 MGI:81294 NCBI chr 9:71,796,204...71,798,265
Ensembl chr 9:71,796,204...71,798,265
JBrowse link
G Epha2 Eph receptor A2 ISO (MGI:3831440|PMID:18948590) RGD PMID:18948590 MGI:3831440 NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206
JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:11850194)
(MGI:1332720|PMID:10080188)
RGD PMID:10080188 PMID:11850194 MGI:1332720 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
G Tbc1d20 TBC1 domain family, member 20 ISO MGI:1856684 (MGI:5551670|PMID:24239381) RGD PMID:24239381 MGI:5551670 NCBI chr 3:147,772,006...147,790,946
Ensembl chr 3:147,772,165...147,789,158
JBrowse link
negative regulation of lens fiber cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxe3 forkhead box E3 involved_in ISS
ISO
PMID:16199865
(MGI:1352262|PMID:10652278), (MGI:1861492|PMID:10890982), (MGI:3603877|PMID:16199865)
RGD PMID:10652278 PMID:10890982 PMID:16199865, PMID:16199865, PMID:16199865 MGI:1352262 MGI:1861492 MGI:3603877, RGD:10047273, RGD:10047273 NCBI chr 5:133,724,796...133,725,656
Ensembl chr 5:133,724,796...133,725,656
JBrowse link
G Spred1 sprouty-related, EVH1 domain containing 1 ISO (MGI:6414698|PMID:29501879) RGD PMID:29501879 MGI:6414698 NCBI chr 3:108,795,337...108,861,650
Ensembl chr 3:108,795,235...108,857,556
JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:6414698|PMID:29501879)
UniProt
RGD
PMID:29501879 GO_REF:0000024 MGI:6414698 NCBI chr14:104,268,362...104,290,206
Ensembl chr14:104,191,517...104,290,456
JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 ISO (MGI:6414698|PMID:29501879) RGD PMID:29501879 MGI:6414698 NCBI chr 1:88,101,213...88,112,719
Ensembl chr 1:88,103,719...88,112,683
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 ISO (MGI:6414698|PMID:29501879) RGD PMID:29501879 MGI:6414698 NCBI chr 2:124,400,689...124,405,331
Ensembl chr 2:124,400,679...124,405,331
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 ISO (MGI:6414698|PMID:29501879) RGD PMID:29501879 MGI:6414698 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802
JBrowse link
positive regulation of lens fiber cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:29501879)
UniProt
RGD
PMID:29501879 GO_REF:0000024 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 ISO (MGI:3604916|PMID:16162653) RGD PMID:16162653 MGI:3604916 NCBI chr 3:29,857,289...29,985,932
Ensembl chr 3:29,862,473...29,996,865
JBrowse link
regulation of lens fiber cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B ISO MGI:104564 (MGI:1309707|PMID:9784491) RGD PMID:9784491 MGI:1309707 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C ISO MGI:104565 (MGI:1309707|PMID:9784491) RGD PMID:9784491 MGI:1309707 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    developmental process 6848
      anatomical structure development 6308
        lens development in camera-type eye 94
          lens fiber cell differentiation 38
            lens fiber cell development + 15
            lens fiber cell fate commitment 0
            negative regulation of lens fiber cell differentiation 6
            positive regulation of lens fiber cell differentiation 2
            regulation of lens fiber cell differentiation + 10
Path 2
Term Annotations click to browse term
  biological_process 20078
    developmental process 6848
      anatomical structure development 6308
        multicellular organism development 5783
          system development 5311
            sensory system development 470
              visual system development 465
                eye development 462
                  camera-type eye development 414
                    lens development in camera-type eye 94
                      lens fiber cell differentiation 38
                        lens fiber cell development + 15
                        lens fiber cell fate commitment 0
                        negative regulation of lens fiber cell differentiation 6
                        positive regulation of lens fiber cell differentiation 2
                        regulation of lens fiber cell differentiation + 10
paths to the root