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ONTOLOGY REPORT - ANNOTATIONS


Term:cornification
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Accession:GO:0070268 term browser browse the term
Definition:A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).



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cornification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp14 caspase 14 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
JBrowse link
G Cers3 ceramide synthase 3 involved_in ISO (MGI:5303015|PMID:22038835) RGD PMID:22038835 MGI:5303015 NCBI chr 1:120,316,930...120,422,926
Ensembl chr 1:120,318,212...120,422,902
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 acts_upstream_of_or_within ISO MGI:3039046 (MGI:5466369|PMID:22366455) RGD PMID:22366455 MGI:5466369 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
JBrowse link
G Tmem79 transmembrane protein 79 acts_upstream_of_or_within ISO MGI:1856947 (MGI:5519142|PMID:24084074) RGD PMID:24084074 MGI:5519142 NCBI chr 2:173,798,267...173,803,151
Ensembl chr 2:173,798,267...173,803,046
JBrowse link
negative regulation of cornification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdsn corneodesmosin involved_in ISO (PMID:26014679) RGD PMID:26014679 NCBI chr20:3,179,432...3,185,854
Ensembl chr20:3,179,438...3,184,250
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    multicellular organismal process 8936
      keratinization 65
        cornification 5
          negative regulation of cornification 1
          positive regulation of cornification 0
          regulation of cornification + 1
Path 2
Term Annotations click to browse term
  biological_process 20099
    developmental process 7010
      anatomical structure development 6447
        tissue development 2205
          epithelium development 1373
            epithelial cell differentiation 809
              epidermal cell differentiation 243
                keratinocyte differentiation 155
                  keratinization 65
                    cornification 5
                      negative regulation of cornification 1
                      positive regulation of cornification 0
                      regulation of cornification + 1
paths to the root